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Rocking pneumonia

Ever since Chuck Berry coined the term “rocking pneumonia” in his 1956 song “Roll over Beethoven”, pneumonia has been mentioned frequently in modern blues and rock songs. We analyzed the lyrics of these songs to examine how various elements of pneumonia have been represented in popular music, specifically the cause of pneumonia, the risk groups, comorbidity (such as the boogie...

Course of SP-D, YKL-40, CCL18 and CA 15-3 in adult patients hospitalised with community-acquired pneumonia and their association with disease severity and aetiology: A post-hoc analysis

, Utrecht, the Netherlands), Ger T Rijkers (St. Antonius Hospital, Nieuwegein, the Netherlands and Roosevelt Academy, Middelburg, the Netherlands), Heleen van Velzen-Blad (St. Antonius Hospital, Nieuwegein ... . Author Contributions Conceptualization: Simone M. C. Spoorenberg, Ger T. Rijkers, Willem Jan W. Bos, Jan C. Grutters. 13 / 16 Data curation: Simone M. C. Spoorenberg, Coline H. M. van Moorsel, Bob Meek

Probiotics for severe trauma patients

Probiotics are live micro-organisms with a health promoting effect. Because of their immunomodulating capacity as well as improvement of gut barrier function, probiotics have the capacity to prevent infectious complications in a variety of clinical settings. Now selected probiotics show potential for improving the clinical outcome of severe trauma patients.

Haemophilus influenzae Serotype b Vaccine Failure: What Is the Significance of Antibody Levels?

Lodewijk Spanjaard 1 Ger T. Rijkers 0 0 Department of Medical Microbiology and Immunology, St. Antonius Hospital , Nieuwegein, the Netherlands 1 Netherlands Reference Laboratory for Bacterial

Microbial aetiology, outcomes, and costs of hospitalisation for community-acquired pneumonia; an observational analysis

Background The aim of this study was to investigate the clinical outcome and especially costs of hospitalisation for community-acquired pneumonia (CAP) in relation to microbial aetiology. This knowledge is indispensable to estimate cost-effectiveness of new strategies aiming to prevent and/or improve clinical outcome of CAP. Methods We performed our observational analysis in a...

Differential expression of TNFR1 (CD120a) and TNFR2 (CD120b) on subpopulations of human monocytes

Background Three subpopulations of monocytes can be distinguished in human blood: classical (CD14++CD16−), intermediate (CD14++CD16+), and nonclassical (CD14+CD16++). CD16 expressing monocytes are expanded in patients with sarcoidosis and in various other inflammatory diseases. In sarcoidosis, it is unclear whether either intermediate, nonclassical or both CD16 expressing...

Impact of Global Fxr Deficiency on Experimental Acute Pancreatitis and Genetic Variation in the FXR Locus in Human Acute Pancreatitis

Background Infectious complications often occur in acute pancreatitis, related to impaired intestinal barrier function, with prolonged disease course and even mortality as a result. The bile salt nuclear receptor farnesoid X receptor (FXR), which is expressed in the ileum, liver and other organs including the pancreas, exhibits anti-inflammatory effects by inhibiting NF-κB...

The influence of the CO2 pneumoperitoneum on a rat model of intestinal anastomosis healing

Stefaan H. A. J. Tytgat 0 Ger T. Rijkers 0 David C. van der Zee 0 0 G. T. Rijkers Department of Surgery, University Medical Center Utrecht , Utrecht, The Netherlands Background The CO2

Intestinal microbiota in human health and disease: the impact of probiotics

The complex communities of microorganisms that colonise the human gastrointestinal tract play an important role in human health. The development of culture-independent molecular techniques has provided new insights in the composition and diversity of the intestinal microbiota. Here, we summarise the present state of the art on the intestinal microbiota with specific attention for...

Prerequisites for cytokine measurements in clinical trials with multiplex immunoassays

Background Growing knowledge about cellular interactions in the immune system, including the central role of cytokine networks, has lead to new treatments using monoclonal antibodies that block specific components of the immune system. Systemic cytokine concentrations can serve as surrogate outcome parameters of these interventions to study inflammatory pathways operative in...

Addition of Vitamin D Status to Prognostic Scores Improves the Prediction of Outcome in Community-Acquired Pneumonia

3 Ger T. Rijkers 10 12 0 Department of Internal Medicine, Gelderse Vallei Hospital , Ede 1 Department of Internal Medicine and Infectious Diseases, University Medical Centre Utrecht 2 Department of

Age-Related Immunity to Meningococcal Serogroup C Vaccination: An Increase in the Persistence of IgG2 Correlates with a Decrease in the Avidity of IgG

Background All children and adolescents between 1 and 19 years of age in The Netherlands received a single meningococcal serogroup C conjugate (MenCC) vaccine in 2002. During follow-up 4–5 years later, the persistence of MenC polysaccharide-specific IgG was found to be dependent on age of vaccination with higher IgG levels in the oldest immunized age categories. Methods and...

Association Analysis of Genetic Variants in the Myosin IXB Gene in Acute Pancreatitis

IntroductionImpairment of the mucosal barrier plays an important role in the pathophysiology of acute pancreatitis. The myosin IXB (MYO9B) gene and the two tight-junction adaptor genes, PARD3 and MAGI2, have been linked to gastrointestinal permeability. Common variants of these genes are associated with celiac disease and inflammatory bowel disease, two other conditions in which...

Probiotics Prevent Intestinal Barrier Dysfunction in Acute Pancreatitis in Rats via Induction of Ileal Mucosal Glutathione Biosynthesis

Background During acute pancreatitis (AP), oxidative stress contributes to intestinal barrier failure. We studied actions of multispecies probiotics on barrier dysfunction and oxidative stress in experimental AP. Methodology/Principal Findings Fifty-three male Spraque-Dawley rats were randomly allocated into five groups: 1) controls, non-operated, 2) sham-operated, 3) AP, 4) AP...

Temperature dependence of mutant mevalonate kinase activity as a pathogenic factor in Hyper-IgD and periodic fever syndrome

Hyper-IgD and periodic fever syndrome (HIDS) and mevalonic aciduria are autosomal recessive disorders characterized by recurrent episodes of fever and generalized inflammation. Both syndromes are caused by specific mutations in the gene encoding mevalonate kinase (MK), resulting in a depressed enzymatic activity mainly due to reduced protein levels. We studied the effect of...

Immunological Characterization of Conjugated Haemophilus influenzae Type b Vaccine Failure in Infants

Infant vaccination with conjugated Haemophilus influenzae type b (Hib) vaccine is highly effective in protecting against invasive Hib infections, but vaccine failures do occur. Twenty-one vaccine failures are reported since the introduction of the Hib conjugate vaccine in The Netherlands. Of the 14 evaluable patients, 6 children showed no antibody response to Hib polysaccharide...

Concentration and Avidity of Anti–Haemophilus influenzae Type b (Hib) Antibodies in Serum Samples Obtained from Patients for Whom Hib Vaccination Failed

Haemophilus influenzae type b (Hib) conjugate vaccines are extremely effective in protecting infants and children from invasive Hib infections; however, vaccine failures do occur. The anti-Hib antibody production was studied both quantitatively and qualitatively in 12 patients who experienced Hib failure, all of whom had normal serum immunoglobulin concentrations and all of whom...

Antibody Response to Haemophilus influenzae Type b Vaccine in Relation to the Number of CD4+ T Lymphocytes in Adults Infected with Human Immunodeficiency Virus

A prospective study of antibody production by adults infected with human immunodeficiency virus (HIV) after vaccination with tetanus toxoid—conjugated Haemophilus influenzae type b (Hib) vaccine was conducted. Concentrations of antibodies to the two immunogenic components of the vaccine (i.e., polyribosylribitolphosphate [PRP] and tetanus toxin) were determined. Individuals were...

Fcγ Receptor Polymorphisms Determine the Magnitude of In Vitro Phagocytosis of Streptococcus pneumoniae Mediated by Pneumococcal Conjugate Sera

Fcγ receptors show two genetically determined polymorphisms: the biallelic FcγRIIa-R 131 and -H131 polymorphism and the NA1/NA2 FcγIIIb polymorphism. Using 10 pre- and postconjugate vaccination sera from adults, we analyzed in vitro phagocytic capacities of three different combinations of polymorphonuclear leukocyte FcγR allotypes: those homozygous for the H131 and NA1 allotype...