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Changes in bone density and bone turnover in patients with rheumatoid arthritis treated with rituximab, results from an exploratory, prospective study

Mastana (Loughborough University, UK) for their statistical advice. Author Contributions Conceptualization: Stephen P. Tuck, Jacob M. van Laar. Data curation: Gillian Wheater, Mohsen Elshahaly, Kamran ... Naraghi. Formal analysis: Gillian Wheater. Funding acquisition: Stephen P. Tuck, Jacob M. van Laar. Investigation: Gillian Wheater, Mohsen Elshahaly, Kamran Naraghi, Jacob M. van Laar. Methodology

The clinical utility of bone marker measurements in osteoporosis

Osteoporosis is characterised by low bone mass and structural deterioration of bone tissue, resulting in increased fragility and susceptibility to fracture. Osteoporotic fractures are a significant cause of morbidity and mortality. Direct medical costs from such fractures in the UK are currently estimated at over two billion pounds per year, resulting in a substantial healthcare...

Induction of long-term B-cell depletion in refractory rheumatoid arthritis patients preferentially affects autoreactive more than protective humoral immunity

Introduction B-cell depletion has become a common treatment strategy in anti-TNF-refractory rheumatoid arthritis (RA). Although the exact mechanism of how B-cell depletion leads to clinical amelioration in RA remains to be elucidated, repetitive treatment with B-cell-depleting agents leading to long-term B-cell depletion has been reported to be beneficial. The latter has led to...