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Novel Epigenetic Changes Unveiled by Monozygotic Twins Discordant for Smoking Habits

Exposure to cigarette smoking affects the epigenome and could increase the risk of developing diseases such as cancer and cardiovascular disorders. Changes in DNA methylation associated with smoking may help to identify molecular pathways that contribute to disease etiology. Previous studies are not completely concordant in the identification of differentially methylated regions...

Complex interplay between neutral and adaptive evolution shaped differential genomic background and disease susceptibility along the Italian peninsula

ScholarSearch for Davide Gentilini in:Nature Research journals • PubMed • Google ScholarSearch for Giovanni Fiorito in:Nature Research journals • PubMed • Google ScholarSearch for Mariagrazia Catanoso in:Nature

Differentially methylated microRNAs in prediagnostic samples of subjects who developed breast cancer in the European Prospective Investigation into Nutrition and Cancer (EPIC-Italy) cohort

) cohort Francesca Cordero Giulio Ferrero 1 Silvia Polidoro 0 Giovanni Fiorito 5 6 Gianluca Campanella 4 Carlotta Sacerdot 3 eAmalia Mattiell 8 o Giovanna Masala 7 Claudia Agnol i Graziella Frasc a

Epigenetic Signatures at AQP3 and SOCS3 Engage in Low-Grade Inflammation across Different Tissues

Background Elevated levels of C-reactive protein (CRP, determined by a high-sensitivity assay) indicate low-grade inflammation which is implicated in many age-related disorders. Epigenetic studies on CRP might discover molecular mechanisms underlying CRP regulation. We aimed to identify DNA methylation sites related to CRP concentrations in cells and tissues regulating low-grade...

Characterization of whole-genome autosomal differences of DNA methylation between men and women

ShemT‑ov Simone Wahl 0 Harald Grallert 0 Giovanni Fiorito SoY‑oun Shin Katharina Schramm Petra Wolf Sonja Kunze 0 Yael Baran Simonetta Guarrera Paolo Vineis Vittorio Krogh Salvatore Panico Rosario Tumino

Gene-specific DNA methylation profiles and LINE-1 hypomethylation are associated with myocardial infarction risk

Background DNA methylation profiles are responsive to environmental stimuli and metabolic shifts. This makes DNA methylation a potential biomarker of environmental-related and lifestyle-driven diseases of adulthood. Therefore, we investigated if white blood cells’ (WBCs) DNA methylation profiles are associated with myocardial infarction (MI) occurrence. Whole-genome DNA...

Sardinians Genetic Background Explained by Runs of Homozygosity and Genomic Regions under Positive Selection

The peculiar position of Sardinia in the Mediterranean sea has rendered its population an interesting biogeographical isolate. The aim of this study was to investigate the genetic population structure, as well as to estimate Runs of Homozygosity and regions under positive selection, using about 1.2 million single nucleotide polymorphisms genotyped in 1077 Sardinian individuals...

An Overview of the Genetic Structure within the Italian Population from Genome-Wide Data

In spite of the common belief of Europe as reasonably homogeneous at genetic level, advances in high-throughput genotyping technology have resolved several gradients which define different geographical areas with good precision. When Northern and Southern European groups were considered separately, there were clear genetic distinctions. Intra-country genetic differences were also...

DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases

Background Chronic low-grade inflammation reflects a subclinical immune response implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA methylation is associated with chronic low-grade inflammation may reveal novel pathways or therapeutic targets for inflammation. Results We performed a meta-analysis of epigenome-wide association studies (EWAS) of...

Genetic Variants Associated with Increased Risk of Malignant Pleural Mesothelioma: A Genome-Wide Association Study

Asbestos exposure is the main risk factor for malignant pleural mesothelioma (MPM), a rare aggressive tumor. Nevertheless, only 5–17% of those exposed to asbestos develop MPM, suggesting the involvement of other environmental and genetic risk factors. To identify the genetic risk factors that may contribute to the development of MPM, we conducted a genome-wide association study...

Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index

Giovanni Fiorito Harald Grallert Simonetta Guarrera Georg Homuth Jennifer E. Huffman David Porteous Generation Scotland Consortium The LifeLines Cohort study The GIANT Consortium Darius Moradpour Alex Iranzo