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Bacterial serine protease HtrA as a promising new target for antimicrobial therapy?

Recent studies have demonstrated that the bacterial chaperone and serine protease high temperature requirement A (HtrA) is closely associated with the establishment and progression of several infectious diseases. HtrA activity enhances bacterial survival under stress conditions, but also has direct effects on functions of the cell adhesion protein E-cadherin and extracellular ...

Inhibitors of Helicobacter pylori Protease HtrA Found by ‘Virtual Ligand’ Screening Combat Bacterial Invasion of Epithelia

Gisbert Schneider 0 Paul Wrede, Charite-Universitatsmedizin Berlin, Germany 0 1 Institute of Organic Chemistry and Chemical Biology, Goethe-University , Frankfurt, Germany , 2 Division of Microbiology