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Search: authors:"Gisbert Schneider"

4 papers found.
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Architecture, function and prediction of long signal peptides

Jan A. Hiss Gisbert Schneider Protein targeting in eukaryotic cells is vital for cell survival and development. N-terminal signal peptides guide proteins to the membrane of the endoplasmic reticulum

Design of MHC I stabilizing peptides by agent-based exploration of sequence space

Identification of molecular features that determine peptide interaction with major histocompatibility complex I (MHC I) is essential for vaccine development. We have developed a concept for peptide design by combining an agent-based artificial ant system with artificial neural networks. A jury of feedforward networks classifies octapeptides that are recognized by mouse MHC I ...

Mapping of protein surface cavities and prediction of enzyme class by a self-organizing neural network

Martin Stahl 0 Chiara Taroni 0 Gisbert Schneider 0 0 F.Hoffmann-La Roche Ltd, Pharmaceuticals Research , CH-4070 Basel , Switzerland 1To whom correspondence should be addressed; email: An automated

Local structural motifs of protein backbones are classified by self-organizing neural networks

Important and relevant information is expected to be encoded in local structural elements of proteins. An unsupervised learning algorithm (Kohonen algorithm) was applied to the representation and unbiased classification of local backbone structures contained in a set of proteins. Training yielded a two-dimensional Kohonen feature map with 100 different structural motifs including ...