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Degenerate String Comparison and Applications

- 173 , 1995 . Michael A. Bender and Martín Farach-Colton . The LCA problem revisited . In LATIN , volume 1776 of LNCS , pages 88 - 94 . Springer, 2000 . Giulia Bernardini , Nadia Pisanti, Solon P. Pissis

Diagnosis of secondary amyloidosis in alkaptonuria

Background Alkaptonuria (AKU) is an inborn error of catabolism due to a deficient activity of homogentisate 1,2-dioxygenase. Patients suffer from a severe arthropathy, cardiovascular and kidney disease but other organs are affected, too. We found secondary amyloidosis as a life-threatening complication in AKU, thus opening new perspectives for its treatment. We proved that...

Post-Genomics and Skin Inflammation

Atopic dermatitis and psoriasis are two chronic skin inflammatory diseases that have so far received a greater attention within the scientific community through different post-genomic approaches; on the contrary, acne, which is undoubtedly one of the most common skin disorders involving inflammatory processes, seems to be still quite neglected under the post-genomic point of view...

Prevalence of Isolated Atrial Amyloidosis in Young Patients Affected by Congestive Heart Failure

Atrial natriuretic peptide (ANP), whose amyloid is responsible of isolated atrial amyloidosis (IAA), is known to play an important role in the pathophysiology of congestive heart failure (CHF). We provide here the microscopic examination of atrial biopsies from 36 young (mean 40 years) CHF patients distinguished in idiopathic dilated cardiomyopathy (DC) affected and hypertrophic...

Amyloidosis, Inflammation, and Oxidative Stress in the Heart of an Alkaptonuric Patient

 Marcella Laschi,1 Michela Geminiani,1 Patrizia Soldani,1 Pietro Lupetti,2 Maurizio Orlandini,1 Chiara Benvenuti,4 Federico Perfetto,5 Adriano Spreafico,6 Giulia Bernardini,1 and Annalisa Santucci1

Different Factors Affecting Human ANP Amyloid Aggregation and Their Implications in Congestive Heart Failure

Aims Atrial Natriuretic Peptide (ANP)-containing amyloid is frequently found in the elderly heart. No data exist regarding ANP aggregation process and its link to pathologies. Our aims were: i) to experimentally prove the presumptive association of Congestive Heart Failure (CHF) and Isolated Atrial Amyloidosis (IAA); ii) to characterize ANP aggregation, thereby elucidating IAA...