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Search: authors:"Giuseppe Manfré"

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BACHD rats expressing full-length mutant huntingtin exhibit differences in social behavior compared to wild-type littermates

Background Huntington disease (HD) is a devastating inherited neurodegenerative disorder characterized by progressive motor, cognitive, and psychiatric symptoms without any cure to slow down or stop the progress of the disease. The BACHD rat model for HD carrying the human full-length mutant huntingtin protein (mHTT) with 97 polyQ repeats has been recently established as a...