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Painful Peripheral Neuropathy and Cancer

Peripheral neuropathy (PN) is very prevalent in cancer patients and a leading cause of pain related to cancer. However, the underlying pathophysiological mechanisms vary significantly. Peripheral neuropathy can be a direct or an indirect complication of cancer or cancer-related treatment, or a pre-existing comorbidity not related to cancer. PN might also occur as a paraneoplastic...

A Pharmacological Rationale to Reduce the Incidence of Opioid Induced Tolerance and Hyperalgesia: A Review

Group srl. Giustino Varrassi, Stephen D. Skaper, Daniele Battelli, Panagiotis Zis, Stefano Coaccioli, Maria Caterina Pace and Antonella Paladini have nothing to disclose. Compliance with Ethics

Pain as a First Manifestation of Paraneoplastic Neuropathies: A Systematic Review and Meta-Analysis

literature review and wrote the manuscript. Antonella Paladini, Alba Piroli, Patrick C. McHugh, Giustino Varrassi, and Marios Hadjivassiliou revised and critically appraised the manuscript. Disclosures ... . Panagiotis Zis, Antonella Paladini, Alba Piroli, Patrick C. McHugh, Giustino Varrassi and Marios Hadjivassiliou have nothing to disclose. Compliance with Ethics Guidelines. This article is based on previously

Change Pain: Ever Evolving—An Update for 2016

Since 1986, the pharmacological management of pain was mainly based on the WHO “analgesic ladder”, with very few drugs available. The huge development of the basic knowledge on pain and its therapy, especially in the past 15 years, has made the “guidelines” of WHO obsolete. That’s why, during the presidency of EFIC of one of the authors (GV), an international advisory board was...

Palmitoylethanolamide in Fibromyalgia: Results from Prospective and Retrospective Observational Studies

publication of this article. Conflict of interest. Rosaria Del Giorno, Stephen Skaper, Antonella Paladini, Giustino Varrassi, and Stefano Coaccioli have nothing to disclose regarding the publication of this

Pain after earthquake

IntroductionOn 6 April 2009, at 03:32 local time, an Mw 6.3 earthquake hit the Abruzzi region of central Italy causing widespread damage in the City of L Aquila and its nearby villages. The earthquake caused 308 casualties and over 1,500 injuries, displaced more than 25,000 people and induced significant damage to more than 10,000 buildings in the L'Aquila region.ObjectivesThis...

Headache prevalence in the population of L’Aquila (Italy) after the 2009 earthquake

Stress induced by the events of daily life is considered a major factor in pathogenesis of primary tension-type headache. Little is known about the impact that could have a more stressful event, like a natural disaster, both in patients with chronic headache, both in people that do not had headache previously. The aim of the present study was to observe the prevalence of headache...