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Differential models of twin correlations in skew for body-mass index (BMI)

by the research training grant 5-T32-MH 13043 from the National Institute of Mental Health. Glen E. Duncan is supported by R56AG042176 (PI: G Duncan) from the National Institute on Aging. Eric ... between twin pairs of the two latent classes by zygosity (NAS-NRC Twin Registry sample). (PDF) Author Contributions Conceptualization: Eric Turkheimer. Data curation: Glen E. Duncan. Formal analysis

The "fit but fat" concept revisited: population-based estimates using NHANES

Low cardiovascular fitness is an independent risk factor for type 2 diabetes and cardiovascular disease in adults. The "fit but fat" concept suggests that cardiovascular fitness attenuates risk of metabolic and cardiovascular disease independent of body mass index (BMI), even among the obese. However, the proportion of U.S. adults considered both fit and obese is unknown. Thus, the ...

Life’s Simple 7 and Incidence of Diabetes Among American Indians: The Strong Heart Family Study

OBJECTIVE The American Heart Association’s recommendations for optimal health, summarized in Life’s Simple 7, have been associated with reduced risk of cardiovascular disease (CVD)-related end points, but no studies have examined the association of these goals with incident type 2 diabetes, which is associated with high risk for CVD. The purpose of this analysis was to examine the ...

Modest Levels of Physical Activity Are Associated With a Lower Incidence of Diabetes in a Population With a High Rate of Obesity: The Strong Heart Family Study

The Strong Heart Family Study AMANDA M. FRETTS PHD BARBARA V. HOWARD PHD BARBARA MCKNIGHT PHD GLEN E. DUNCAN PHD SHIRLEY A.A. BERESFORD PHD DARREN CALHOUN PHD ANDREA M. KRISKA PHD KRISTI L. STORTI

Unique Environmental Effects on Physical Activity Participation: A Twin Study

BackgroundThe health benefits of regular physical activity are well established. However, the relative contribution of heritable and environmental factors to physical activity participation remains controversial. Using a cut-point of 60 minutes of total activity per week, data from the GenomEUtwin project revealed consistent genetic influence on physical activity participation in ...

Age and kidney function are the primary correlates of fasting plasma total homocysteine levels in non-diabetic and diabetic adults. Results from the 1999–2002 National Health and Nutrition Examination Survey

Background Plasma total homocysteine (tHcy) is commonly elevated in persons with diabetes. This may be due to effects of insulin and/or glucose and/or metabolic control on the metabolism or plasma levels of tHcy. This study examined the effects of fasting plasma glucose status on fasting tHcy levels among adults without diabetes, and diabetes per se among adults with a self-report ...

Prevalence and Trends of a Metabolic Syndrome Phenotype Among U.S. Adolescents, 1999–2000

OBJECTIVE—To determine the prevalence of a metabolic syndrome phenotype among U.S. adolescents using the most recent national data and to examine trends in metabolic syndrome prevalence. RESEARCH DESIGN AND METHODS—Analysis of data on 991 adolescents (aged 12–19 years) who had fasted for at least 6 h, from the National Health and Nutrition Examination Survey (NHANES 1999–2000). The ...

Exercise Training, Without Weight Loss, Increases Insulin Sensitivity and Postheparin Plasma Lipase Activity in Previously Sedentary Adults

OBJECTIVE—To determine the effects of exercise, without weight loss, on insulin sensitivity (SI), postheparin plasma lipase activity (PHPL), intravenous fat clearance rate (K2), and fasting lipids in sedentary adults. RESEARCH DESIGN AND METHODS—At baseline and after 6 months of walk training (intensity 45–55 or 65–75% heart rate reserve, frequency 3–4 or 5–7 days/week, duration 30 ...