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Higher serum choline and betaine levels are associated with better body composition in male but not female population

participated in this present study. 12 / 15 Author Contributions Data curation: Xiang Gao, Edward Randell. Formal analysis: Xiang Gao. Funding acquisition: Guang Sun. Methodology: Xiang Gao, Guang Sun ... . Resources: Guang Sun. Software: Haicheng Zhou. Supervision: Guang Sun. Validation: Xiang Gao. Writing ± original draft: Xiang Gao. Writing ± review & editing: Edward Randell, Haicheng Zhou, Guang Sun. 13

Hyperglycemia-related advanced glycation end-products is associated with the altered phosphatidylcholine metabolism in osteoarthritis patients with diabetes

: Guangju Zhai. Validation: Edward W. Randell, Guang Sun, Guangju Zhai. Writing ± original draft: Weidong Zhang. Writing ± review & editing: Edward W. Randell, Guang Sun, Sergei Likhodii, Ming Liu, Andrew

High dietary selenium intake is associated with less insulin resistance in the Newfoundland population

As an essential nutrient, Selenium (Se) is involved in many metabolic activities including mimicking insulin function. Data on Se in various biological samples and insulin resistance are contradictory, moreover there is no large study available regarding the relationship of dietary Se intake with insulin resistance in the general population. To investigate the association between...

Higher Dietary Choline and Betaine Intakes Are Associated with Better Body Composition in the Adult Population of Newfoundland, Canada

Guang Sun. Xiang Gao was supported by grants from National Natural Science Foundation of China (No. 31371757), State Key Program of National Natural Science Foundation of China (No. 31330060) and

A Neighborhood-based Matrix Factorization Technique for Recommendation

The data sparsity and prediction quality are recognized as the key challenges in the existing recommender Systems. Most of the existing recommender systems depend on collaborating flitering (CF) method which mainly leverages the user-item rating matrix representing the relationship between users and items. However, the CF-based method sometimes fails to provide accurate...

Serum metabolic biomarkers distinguish metabolically healthy peripherally obese from unhealthy centrally obese individuals

been funded by a Canadian Institutes of Health Research (CIHR) (operating grant: MOP192552) and an A.R.COX Award (operating grant) to Guang Sun. Xiang Gao was supported by grants from National Natural

Association of CYP1B1 L432V polymorphism with urinary cancer susceptibility: a meta-analysis

Background The Cytochrome P450 1B1 (CYP1B1) is a key P450 enzyme involved in the metabolism of exogenous and endogenous substrates. Previous studies have reported the existence of CYP1B1 L432V missense polymorphism in prostate, bladder and renal cancers. However, the effects of this polymorphism on the risk of these cancers remain conflicting. Therefore, we performed a meta...

Epigenetic Regulation of Elf5 Is Associated with Epithelial-Mesenchymal Transition in Urothelial Cancer

E74-like factor 5 (Elf5) has been associated with tumor suppression in breast cancer. However, its role in urothelial cancer (UC) is completely unknown. Immunohistochemistry (IHC) and methylation specific PCR (MSP) were done to detect Elf5 expression level and its promoter methylation. Results revealed that low expression of Elf5 on protein and mRNA levels were associated with...

The Association of Serum Total Peptide YY (PYY) with Obesity and Body Fat Measures in the CODING Study

Background PYY is an appetite suppressing hormone. Low circulating PYY has been linked to greater BMI. However data is controversial and this association has not been verified in large human populations. Objective The purpose of this study was to investigate if fasting serum total PYY is associated with obesity status and/or adiposity at the population level. Design A total of...

Norcantharidin induces growth inhibition and apoptosis of glioma cells by blocking the Raf/MEK/ERK pathway

Background Malignant gliomas represent the most common primary brain tumors. The prognosis of patients with malignant gliomas is poor in spite of current intensive therapy and novel therapeutic modalities are needed. Here we report that norcantharidin is effective in growth inhibition of glioma cell lines in vitro. Methods Glioma cell lines (U87 and C6) were treated with...

Short-Term Overfeeding Increases Circulating Adiponectin Independent of Obesity Status

Background Adiponectin is an adipose tissue derived hormone which strengthens insulin sensitivity. However, there is little data available regarding the influence of a positive energy challenge (PEC) on circulating adiponectin and the role of obesity status on this response. Objective The purpose of this study was to investigate how circulating adiponectin will respond to a short...

Weighted Change-Point Method for Detecting Differential Gene Expression in Breast Cancer Microarray Data

In previous work, we proposed a method for detecting differential gene expression based on change-point of expression profile. This non-parametric change-point method gave promising result in both simulation study and public dataset experiment. However, the performance is still limited by the less sensitiveness to the right bound and the statistical significance of the statistics...

Circulating glucagon-like peptide-1 increases in response to short-term overfeeding in men

Background Glucagon-like Peptide-1 (GLP-1) is an incretin hormone secreted from the gastrointestinal tract that facilitates the glucose-dependent insulin response. Additionally, GLP-1 is thought to be involved in energy homeostasis. Currently little is known about GLP-1’s responsiveness to an energy surplus, a fundamental cause of obesity and diabetes. Our objective was to...

High Dietary Magnesium Intake Is Associated with Low Insulin Resistance in the Newfoundland Population

Institute for Health Research (operating grant: OOP-77984 to Guang Sun). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Downregulation of protocadherin-10 expression correlates with malignant behaviour and poor prognosis in human bladder cancer

Objectives This study retrospectively evaluated the prognostic significance of downregulated protocadherin-10 (PCDH10) gene expression in bladder cancer.

SMAD3 Is Associated with the Total Burden of Radiographic Osteoarthritis: The Chingford Study

Background A newly-described syndrome called Aneurysm-Osteoarthritis Syndrome (AOS) was recently reported. AOS presents with early onset osteoarthritis (OA) in multiple joints, together with aneurysms in major arteries, and is caused by rare mutations in SMAD3. Because of the similarity of AOS to idiopathic generalized OA (GOA), we hypothesized that SMAD3 is also associated with...

Serum Acylated Ghrelin Concentrations in Response to Short-Term Overfeeding in Normal Weight, Overweight, and Obese Men

Background Ghrelin, an orexigenic gut hormone secreted primarily from the stomach, is involved in energy homeostasis. However, little data is available regarding its response to energy surplus and the development of human obesity. Objective The present study investigated the response of circulating acylated ghrelin to a 7-day positive energy challenge. Design A total of 68...

Food Addiction: Its Prevalence and Significant Association with Obesity in the General Population

population with higher rate in women as compared to men. - Funding: The study has been funded by a CIHR operating grant and CFI equipment grant to Dr. Guang Sun (CIHR: MOP192552). The funders had no role in

Assessing the validity of a self-administered food-frequency questionnaire (FFQ) in the adult population of Newfoundland and Labrador, Canada

Background The Food- Frequency Questionnaire (FFQ) is a dietary assessment tool frequently used in large-scale nutritional epidemiology studies. The goal of the present study is to validate a self-administered version of the Hawaii FFQ modified for use in the general adult population of Newfoundland and Labrador (NL). Methods Over a one year period, 195 randomly selected adults...