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21 papers found.
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Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome

GUIDELINES Zeming Wu, Weiqi Zhang, Moshi Song, Wei Wang, Gang Wei, Wei Li, Jinghui Lei, Yu Huang, Yanmei Sang, Piu Chan, Chang Chen, Jing Qu, Keiichiro Suzuki, Juan Carlos Izpisua Belmonte and Guang-Hui Liu

CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs

Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease with cellular and molecular mechanisms yet to be fully described. Mutations in a number of genes including SOD1 and FUS are associated with familial ALS. Here we report the generation of induced pluripotent stem cells (iPSCs) from fibroblasts of familial ALS patients bearing SOD1 +/A272C and FUS +/G1566A...

ROR1, an embryonic protein with an emerging role in cancer biology

. COMPLIANCE WITH ETHICS GUIDELINES Nicholas Borcherding, David Kusner, Guang-Hui Liu and Weizhou Zhang declare that they have no conflict of interest. This article does not contain any studies with human or

CRISPR/Cas9 and TALE: beyond cut and paste

, Ruotong Ren, Jun Wu, Keiichiro Suzuki, Juan Carlos Izpisua Belmonte, and Guang-Hui Liu declare no conflict of interest. This article is distributed under the terms of the Creative Commons Attribution

Vitamin C alleviates aging defects in a stem cell model for Werner syndrome

Ye, Yu Wang, Jian Li, Jie Qiao, Jing Qu, Weiqi Zhang, and Guang-Hui Liu declare that they have no conflict of interest. All institutional and national guidelines for the care and use of laboratory

Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs

Qiao, Juan Carlos Izpisua Belmonte, Jing Qu, and Guang-Hui Liu declare that they have no conflict of interest. All institutional and national guidelines for the care and use of laboratory animals were

Evolution of iPSC disease models

Weiqi Zhang 0 Zhichao Ding 0 Guang-Hui Liu 0 0 National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences , Beijing 100101, China - Human induced pluripotent

Inflammasomes in cancer: a double-edged sword

factor-α. COMPLIANCE WITH ETHICS GUIDELINES Ryan Kolb, Guang-Hui Liu, Ann M. Janowski, Fayyaz S. Sutterwala, and Weizhou Zhang declare that they have no conflict of interest. This article does not

Sumoylation Regulates Nuclear Localization of Lipin-1α in Neuronal Cells

Lipin-1 is a protein that has dual functions as a phosphatidic acid phosphohydrolase (PAP) and a nuclear transcriptional coactivator. It remains unknown how the nuclear localization and coactivator functions of lipin-1 are regulated. Here, we show that lipin-1 (including both the alpha and beta isoforms) is modified by sumoylation at two consensus sumoylation sites. We are unable...

Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug development and cell therapy

Recent advances in the study of human hepatocytes derived from induced pluripotent stem cells (iPSC) represent new promises for liver disease study and drug discovery. Human hepatocytes or hepatocyte-like cells differentiated from iPSC recapitulate many functional properties of primary human hepatocytes and have been demonstrated as a powerful and efficient tool to model human...

Direct conversion of human fibroblasts into retinal pigment epithelium-like cells by defined factors

revised in 2000 (5). Informed consent was obtained from all patients for being included in the study. Kejing Zhang, Guang-Hui Liu, Fei Yi, Nuria Montserrat, Tomoaki Hishida, Concepcion Rodriguez Esteban

Find and replace: editing human genome in pluripotent stem cells

Genetic manipulation of human pluripotent stem cells (hPSCs) provides a powerful tool for modeling diseases and developing future medicine. Recently a number of independent genome-editing techniques were developed, including plasmid, bacterial artificial chromosome, adeno-associated virus vector, zinc finger nuclease, transcription activator-like effecter nuclease, and helper...

Characterization of a novel mouse model with genetic deletion of CD177

Tygrett, Thomas Waldschmidt, Alicia Olivier, Songhai Chen, Guang-Hui Liu, Xiangrui Li, and Weizhou Zhang declare that they have no conflict of interest. This article does not contain any studies with human

Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes

. COMPLIANCE WITH ETHICS GUIDELINES Ying Gu, Guang-Hui Liu, Nongluk Plongthongkum, Christopher Benner, Fei Yi, Jing Qu, Keiichiro Suzuki, Jiping Yang, Weiqi Zhang, Mo Li, Nuria Montserrat, Isaac Crespo, Antonio

Nitric oxide controls nuclear export of APE1/Ref-1 through S-nitrosation of Cysteines 93 and 310

Apurinic/apyrimidinic endonuclease 1/redox effector factor-1 (APE1/Ref-1, abbreviated as APE1) is a molecule with dual functions in DNA repair and redox regulation of transcription factors. Accumulated work has shown that the biological activities of APE1 are sensitive to oxidative stress; however, whether APE1 functions can be regulated by nitrosative stress remains unknown. In...

Direct reprogramming of porcine fibroblasts to neural progenitor cells

, Ting-Ting Yuan, Guo-Hong Yuan, Li-Na Sui, Di Guan, Shun-Lei Duan, Hui-Ze Pan, Ping Wang, Xi-Ping Zhu, Nuria Montserrat, Ming Li, Rui-Jun Bai, Lin Liu, Juan Carlos Izpisua Belmonte, and Guang-Hui Liu