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31 papers found.
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Nucleolar and coiled-body phosphoprotein 1 (NOLC1) regulates the nucleolar retention of TRF2

Telomeric repeat-binding factor 2 (TRF2) was reported to localize in the nucleolus of human cells in a cell cycle-dependent manner; however, the underlying mechanism remains unclear. Here, we found that nucleolar and coiled-body phosphoprotein 1 (NOLC1) interacted with TRF2 and mediated the shuttling of TRF2 between the nucleolus and nucleus in human 293T and HepG2 cells...

Micheliolide suppresses LPS-induced neuroinflammatory responses

administration: Guodong Li. Resources: Guodong Li. Software: Guodong Li. Supervision: Tanjun Tong. Validation: Zhaomeng Sun. Visualization: Zhaomeng Sun. Writing ± original draft: Zhaomeng Sun, Jun Chen

Levels of Inflammatory Cytokines IL-1β, IL-6, IL-8, IL-17A, and TNF-α in Aqueous Humour of Patients with Diabetic Retinopathy

Qingjun Lv,4 Li Lu,3 Ting Liu,3 Guodong Li,5 and Ling Yuan3 1Department of Ophthalmology, ZhuJiang Hospital of Southern Medical University, Guangzhou 510280, China 2Department of Ophthalmology, Guangdong

Human colorectal cancer-derived mesenchymal stem cells promote colorectal cancer progression through IL-6/JAK2/STAT3 signaling

, Geng Li, Guodong Li, Xi Yang, Liang Liu, Rongsheng Zhang & Yongdong FengHepatic Surgery Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei ... Scholar Search for Geng Li in:Nature Research journals • PubMed • Google Scholar Search for Guodong Li in:Nature Research journals • PubMed • Google Scholar Search for Xi Yang in:Nature Research journals

Combining FMEA with DEMATEL models to solve production process problems

manuscript. 12 / 15 Author Contributions Conceptualization: Sang-Bing Tsai, Jie Zhou, Yang Gao. Data curation: Jiangtao Wang, Guodong Li, Yuxiang Zheng, Peng Ren, Wei Xu. Formal analysis: Sang-Bing Tsai ... , Jie Zhou, Yang Gao. Funding acquisition: Jiangtao Wang, Guodong Li, Yuxiang Zheng, Peng Ren, Wei Xu. Investigation: Sang-Bing Tsai, Jie Zhou, Yang Gao. Methodology: Sang-Bing Tsai. Project

An empirical research on relationships between subjective judgement, technology acceptance tendency and knowledge transfer

The purpose of this study was to explore the relationships among employees' usage intention pertaining to mobile information devices, focusing on subjective judgement, technology acceptance tendency, information sharing behavior and information transfer. A research model was established to verify several hypotheses. The research model based on integrated concepts of knowledge...

An empirical research on evaluating banks’ credit assessment of corporate customers

Background Under the rapid change of the global financial environment, the risk control of the credit granting is viewed as the foremost task to each bank. With the impact one by one from financial crisis and European debt crisis, the steady bank business is also facing the severe challenge. Banks approve the credits for their customers and then make money from the interest. Case...

Load Bearing and Deformation Characteristics of Granular Spoils under Unconfined Compressive Loading for Coal Mine Backfill

. Aggelis Copyright © 2016 Guodong Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any

Load Bearing and Deformation Characteristics of Granular Spoils under Unconfined Compressive Loading for Coal Mine Backfill

. Aggelis Copyright © 2016 Guodong Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any

Discovery and Validation of Hypermethylated Markers for Colorectal Cancer

-Specific Polymerase Chain ReactionROC:Receiver operating characteristicUTR:Untranslated Regions.Disclosure Guodong Li is a co-first author. Competing Interests The authors declare that there is no conflict ... of interests regarding the publication of this paper. Authors’ Contributions Jiufeng Wei and Guodong Li contributed equally as first authors. Acknowledgments This work is supported by National Natural

Nucleostemin Knockdown Sensitizes Hepatocellular Carcinoma Cells to Ultraviolet and Serum Starvation-Induced Apoptosis

Nucleostemin (NS) is a GTP-binding protein that is predominantly expressed in embryonic and adult stem cells but not in terminally differentiated cells. NS plays an essential role in maintaining the continuous proliferation of stem cells and some types of cancer cells. However, the role of NS in hepatocellular carcinoma (HCC) remains unclear. Therefore, this study aimed to...

Adaptive Hybrid Visual Servo Regulation of Mobile Robots Based on Fast Homography Decomposition

For the monocular camera-based mobile robot system, an adaptive hybrid visual servo regulation algorithm which is based on a fast homography decomposition method is proposed to drive the mobile robot to its desired position and orientation, even when object’s imaging depth and camera’s position extrinsic parameters are unknown. Firstly, the homography’s particular properties...

Climate Change and the Macroeconomic Structure in Pre-Industrial Europe: New Evidence from Wavelet Analysis

The relationship between climate change and the macroeconomy in pre-industrial Europe has attracted considerable attention in recent years. This study follows the combined paradigms of evolutionary economics and ecological economics, in which wavelet analysis (spectrum analysis and coherence analysis) is applied as the first attempt to examine the relationship between climate...

miR-221 Promotes Epithelial-Mesenchymal Transition through Targeting PTEN and Forms a Positive Feedback Loop with β-catenin/c-Jun Signaling Pathway in Extra-Hepatic Cholangiocarcinoma

Extrahepatic cholangiocarcinoma (EHCC) is a refractory malignancy with poor prognosis due to its early invasion, metastasis and recurrence after operation. Therefore, understanding the mechanisms of invasion and metastasis is the key to the development of new and effective therapeutic strategies for EHCC. In the present study we demonstrated that miR-221 promoted EHCC invasion...

GMEnzy: A Genetically Modified Enzybiotic Database

affiliated with SHUB and currently works on SKLGE for joint postdoctoral research. Guodong Li is the CTO at SHUB. Qingshan Huang is affiliated with Fudan University and as a paid consultant at SHUB. Guodong Li

Quantitative Analysis of Adulterations in Oat Flour by FT-NIR Spectroscopy, Incomplete Unbalanced Randomized Block Design, and Partial Least Squares

This paper developed a rapid and nondestructive method for quantitative analysis of a cheaper adulterant (wheat flour) in oat flour by NIR spectroscopy and chemometrics. Reflectance FT-NIR spectra in the range of 4000 to 12000 cm−1 of 300 oat flour objects adulterated with wheat flour were measured. The doping levels of wheat flour ranged from 5% to 50% (w/w). To ensure the...

microRNA-34a inhibits epithelial mesenchymal transition in human cholangiocarcinoma by targeting Smad4 through transforming growth factor-beta/Smad pathway

Background Extrahepatic Cholangiocarcinoma (EHCC) is one of the uncommon malignancies in the digestive system which is characterized by a poor prognosis. Aberrations of miRNAs have been shown involved in the progression of this disease. In this study, we evaluated the expression and effects of miR-34a on EHCC. Methods miR-34a expression levels were detected in EHCC tissues...

Different MMSE Score Is Associated with Postoperative Delirium in Young-Old and Old-Old Adults

Background Postoperative delirium is one of the most common postoperative complications in geriatric patients. Mini-mental state examination (MMSE) assesses cognitive function in patients and is associated with postoperative delirium. However, whether there is an age-dependent relationship between preoperative MMSE score and postoperative delirium remains unknown. Methods We...

The extracellular death factor (EDF) protects Escherichia coli by scavenging hydroxyl radicals induced by bactericidal antibiotics

The newly discovered extracellular death factor (EDF) is a pentapeptide with the sequence NNWNN in Escherichia coli. It was reported that it participated in the cell death process mediated by toxin-antitoxin system mazEF. Reactive oxygen species (ROS) are recently considered as common factors for bactericidal antibiotics-mediated cell death. Previous study indicated that EDF...

All-Arthroscopic versus Mini-Open Repair of Small to Large Sized Rotator Cuff Tears: A Meta-Analysis of Clinical Outcomes

Purpose The purpose of this study was to compare clinical outcomes of patients with full-thickness small to large sized tears undergoing all-arthroscopic versus mini-open rotator cuff repair. Method A literature search for electronic databases and references for eligible studies was conducted through Medline, Embase and Cochrane library between 1969 and 2013. Results A total of...