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23 papers found.
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Micheliolide suppresses LPS-induced neuroinflammatory responses

administration: Guodong Li. Resources: Guodong Li. Software: Guodong Li. Supervision: Tanjun Tong. Validation: Zhaomeng Sun. Visualization: Zhaomeng Sun. Writing ± original draft: Zhaomeng Sun, Jun Chen

Combining FMEA with DEMATEL models to solve production process problems

manuscript. 12 / 15 Author Contributions Conceptualization: Sang-Bing Tsai, Jie Zhou, Yang Gao. Data curation: Jiangtao Wang, Guodong Li, Yuxiang Zheng, Peng Ren, Wei Xu. Formal analysis: Sang-Bing Tsai ... , Jie Zhou, Yang Gao. Funding acquisition: Jiangtao Wang, Guodong Li, Yuxiang Zheng, Peng Ren, Wei Xu. Investigation: Sang-Bing Tsai, Jie Zhou, Yang Gao. Methodology: Sang-Bing Tsai. Project

An empirical research on relationships between subjective judgement, technology acceptance tendency and knowledge transfer

The purpose of this study was to explore the relationships among employees' usage intention pertaining to mobile information devices, focusing on subjective judgement, technology acceptance tendency, information sharing behavior and information transfer. A research model was established to verify several hypotheses. The research model based on integrated concepts of knowledge ...

An empirical research on evaluating banks’ credit assessment of corporate customers

Background Under the rapid change of the global financial environment, the risk control of the credit granting is viewed as the foremost task to each bank. With the impact one by one from financial crisis and European debt crisis, the steady bank business is also facing the severe challenge. Banks approve the credits for their customers and then make money from the interest. Case ...

Nucleostemin Knockdown Sensitizes Hepatocellular Carcinoma Cells to Ultraviolet and Serum Starvation-Induced Apoptosis

Nucleostemin (NS) is a GTP-binding protein that is predominantly expressed in embryonic and adult stem cells but not in terminally differentiated cells. NS plays an essential role in maintaining the continuous proliferation of stem cells and some types of cancer cells. However, the role of NS in hepatocellular carcinoma (HCC) remains unclear. Therefore, this study aimed to clarify ...

Climate Change and the Macroeconomic Structure in Pre-Industrial Europe: New Evidence from Wavelet Analysis

The relationship between climate change and the macroeconomy in pre-industrial Europe has attracted considerable attention in recent years. This study follows the combined paradigms of evolutionary economics and ecological economics, in which wavelet analysis (spectrum analysis and coherence analysis) is applied as the first attempt to examine the relationship between climate ...

miR-221 Promotes Epithelial-Mesenchymal Transition through Targeting PTEN and Forms a Positive Feedback Loop with β-catenin/c-Jun Signaling Pathway in Extra-Hepatic Cholangiocarcinoma

Extrahepatic cholangiocarcinoma (EHCC) is a refractory malignancy with poor prognosis due to its early invasion, metastasis and recurrence after operation. Therefore, understanding the mechanisms of invasion and metastasis is the key to the development of new and effective therapeutic strategies for EHCC. In the present study we demonstrated that miR-221 promoted EHCC invasion and ...

microRNA-34a inhibits epithelial mesenchymal transition in human cholangiocarcinoma by targeting Smad4 through transforming growth factor-beta/Smad pathway

Background Extrahepatic Cholangiocarcinoma (EHCC) is one of the uncommon malignancies in the digestive system which is characterized by a poor prognosis. Aberrations of miRNAs have been shown involved in the progression of this disease. In this study, we evaluated the expression and effects of miR-34a on EHCC. Methods miR-34a expression levels were detected in EHCC tissues, ...

Different MMSE Score Is Associated with Postoperative Delirium in Young-Old and Old-Old Adults

Background Postoperative delirium is one of the most common postoperative complications in geriatric patients. Mini-mental state examination (MMSE) assesses cognitive function in patients and is associated with postoperative delirium. However, whether there is an age-dependent relationship between preoperative MMSE score and postoperative delirium remains unknown. Methods We ...

GMEnzy: A Genetically Modified Enzybiotic Database

affiliated with SHUB and currently works on SKLGE for joint postdoctoral research. Guodong Li is the CTO at SHUB. Qingshan Huang is affiliated with Fudan University and as a paid consultant at SHUB. Guodong Li

The extracellular death factor (EDF) protects Escherichia coli by scavenging hydroxyl radicals induced by bactericidal antibiotics

The newly discovered extracellular death factor (EDF) is a pentapeptide with the sequence NNWNN in Escherichia coli. It was reported that it participated in the cell death process mediated by toxin-antitoxin system mazEF. Reactive oxygen species (ROS) are recently considered as common factors for bactericidal antibiotics-mediated cell death. Previous study indicated that EDF could ...

All-Arthroscopic versus Mini-Open Repair of Small to Large Sized Rotator Cuff Tears: A Meta-Analysis of Clinical Outcomes

Purpose The purpose of this study was to compare clinical outcomes of patients with full-thickness small to large sized tears undergoing all-arthroscopic versus mini-open rotator cuff repair. Method A literature search for electronic databases and references for eligible studies was conducted through Medline, Embase and Cochrane library between 1969 and 2013. Results A total of 12 ...

Climate Change and Macro-Economic Cycles in Pre-Industrial Europe

Climate change has been proven to be the ultimate cause of social crisis in pre-industrial Europe at a large scale. However, detailed analyses on climate change and macro-economic cycles in the pre-industrial era remain lacking, especially within different temporal scales. Therefore, fine-grained, paleo-climate, and economic data were employed with statistical methods to ...

LAMP: A Database Linking Antimicrobial Peptides

Fudan University. The program of Master of Engineering in China set two mentors from University and Industry respectively. Her two mentors are Guodong Li and Qingshan Huang, from SHUB and SKLGE separately ... . Hongyu Wu is affiliated SHUB as a paid employee. Hairong Lu is affiliated SHUB as a paid employee and currently major in Genetics as a PhD student at SKLGE. Guodong Li is the CTO at SHUB. Qingshan Huang is

A Novel Controlled-Release System for Antibacterial Enzyme Lysostaphin Delivery Using Hydroxyapatite/Chitosan Composite Bone Cement

and Guodong Li are paid employees of SHUB. Zhizhong Cao is a professor of Department of Stomatology in Changhai Hospital of Second Military Medical University. Qingshan Huang is a professor of SKLGE in

Outcome of Hemiarthroplasty and Total Hip Replacement for Active Elderly Patients with Displaced Femoral Neck Fractures: A Meta-Analysis of 8 Randomized Clinical Trials

Background Displaced fracture of the femoral neck has been a common clinical problem, especially in aged patients. However, the optimal treatment choice remains controversial. The purpose of this study is to conduct a systematic review of randomized clinical trials assessing the results of hemiarthroplasty and total hip replacement in patients undergoing either alternative using ...

Thermoelectricity from wasted heat of integrated circuits

We demonstrate that waste heat from integrated circuits especially computer microprocessors can be recycled as valuable electricity to power up a portion of the circuitry or other important accessories such as on-chip cooling modules, etc. This gives a positive spin to a negative effect of ever increasing heat dissipation associated with increased power consumption aligned with ...

EnzyBase: a novel database for enzybiotic studies

Background Enzybiotics are becoming increasingly recognized as potential alternative therapies for drug-resistant bacteria. Although only a few enzybiotics are currently well characterized, much information is still missing or is unavailable for researchers. The construction of an enzybiotics database would therefore increase efficiency and convenience in investigating these ...

High Glucose Predisposes Gene Expression and ERK Phosphorylation to Apoptosis and Impaired Glucose-Stimulated Insulin Secretion via the Cytoskeleton

Chronic high glucose (HG) inflicts glucotoxicity on vulnerable cell types such as pancreatic β cells and contributes to insulin resistance and impaired insulin secretion in diabetic patients. To identify HG-induced cellular aberrations that are candidate mediators of glucotoxicity in pancreatic β cells, we analyzed gene expression in ERoSHK6, a mouse insulin-secreting cell line ...

Farnesoid X Receptor Induces Murine Scavenger Receptor Class B Type I via Intron Binding

Farnesoid X receptor (FXR) is a nuclear receptor and a key regulator of liver cholesterol and triglyceride homeostasis. Scavenger receptor class B type I (SR-BI) is critical for reverse cholesterol transport (RCT) by transporting high-density lipoprotein (HDL) into liver. FXR induces SR-BI, however, the underlying molecular mechanism of this induction is not known. The current ...