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Search: authors:"Guy S. Salvesen"

6 papers found.
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A remarkable activity of human leukotriene A4 hydrolase (LTA4H) toward unnatural amino acids

Leukotriene A4 hydrolase (LTA4H––EC is a bifunctional zinc metalloenzyme, which processes LTA4 through an epoxide hydrolase activity and is also able to trim one amino acid at a time from N-terminal peptidic substrates via its aminopeptidase activity. In this report, we have utilized a library of 130 individual proteinogenic and unnatural amino acid fluorogenic...

Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4

Human neutrophil serine protease 4 (NSP4), also known as PRSS57, is a recently discovered fourth member of the neutrophil serine proteases family. Although its biological function is not precisely defined, it is suggested to regulate neutrophil response and innate immune reactions. To create optimal substrates and visualization probes for NSP4 that distinguish it from other NSPs...

Caspase Cleavage Sites in the Human Proteome: CaspDB, a Database of Predicted Substrates

Bram J. van Raam 0 Guy S. Salvesen 0 Piotr Cieplak 0 Shawn B. Bratton, The University of Texas MD Anderson Cancer Center, United States of America 0 Sanford Burnham Medical Research Institute , La Jolla

Regulation of the Apaf-1–caspase-9 apoptosome

Shawn B. Bratton 1 Guy S. Salvesen 0 0 Program in Apoptosis and Cell Death Research, Sanford-Burnham Medical Research Institute , 10901 North Torrey Pines Road, La Jolla, CA 92037 , USA 1 Division

Fingerprinting the Substrate Specificity of M1 and M17 Aminopeptidases of Human Malaria, Plasmodium falciparum

Poreba Sheena McGowan Tina S. Skinner-Adams Katharine R. Trenholme Donald L. Gardiner James C. Whisstock Joyce To Guy S. Salvesen John P. Dalton Marcin Drag Photini Sinnis, Johns Hopkins Bloomberg School

Caspase activation – stepping on the gas or releasing the brakes? Lessons from humans and flies

The central components of the execution phase of apoptosis in worms, flies, and humans are members of the caspase protease family. Work in Drosophila and mammalian systems has revealed a web of interactions that govern the activity of these proteases, and two fundamental control points have been identified. These are zymogen activation – the process that converts a latent caspase...