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Climate change-associated trends in biomass dynamics are consistent across soil drainage classes in western boreal forests of Canada

Background Consistent long-term declines in net aboveground biomass change have been reported in some boreal and tropical forests. Global change-type drought (i.e., demands of increased evapotranspiration exceeding soil water reserves) has been identified as the main driver for these declines. Despite the focus on reduced water availability, most studies relegate local site soil ...

Cardiac events during treatment with proteasome inhibitor therapy for multiple myeloma

Background Proteasome inhibitors (PI) bortezomib and carfilzomib are cornerstone therapies for multiple myeloma. Higher incidence of cardiac adverse events (CAEs) has been reported in patients receiving carfilzomib. However, risk factors for cardiac toxicity remain unclear. Our objective was to evaluate the incidence of CAEs associated with PI and recognize risk factors for ...

Optimal Compressed Sensing and Reconstruction of Unstructured Mesh Datasets

Exascale computing promises quantities of data too large to efficiently store and transfer across networks in order to be able to analyze and visualize the results. We investigate compressed sensing (CS) as an in situ method to reduce the size of the data as it is being generated during a large-scale simulation. CS works by sampling the data on the computational cluster within an ...

Harnessing the early post-injury inflammatory responses for cardiac regeneration

Cardiac inflammation is considered by many as the main driving force in prolonging the pathological condition in the heart after myocardial infarction. Immediately after cardiac ischemic injury, neutrophils are the first innate immune cells recruited to the ischemic myocardium within the first 24 h. Once they have infiltrated the injured myocardium, neutrophils would then secret ...

Trust in Immigration Enforcement: State Noncooperation and Sanctuary Cities After Secure Communities

AFTER SECURE COMMUNITIES MING H. CHEN INTRODUCTION The conventional wisdom, backed by legitimacy research, is that most people obey most of the laws, most of the time. This turns out to not be the case

Correction: Tensor based multichannel reconstruction for breast tumours identification from DCE-MRIs

Citation: Yin X-X, Hadjiloucas S, Chen J-H, Zhang 0 Radiology, E-Da Hospital and I-Shou University , Kaohsiung , Taiwan 1 There is an error in affiliation 4 for author J. -H. Chen. Affiliation 4 should be

Tensor based multichannel reconstruction for breast tumours identification from DCE-MRIs

A new methodology based on tensor algebra that uses a higher order singular value decomposition to perform three-dimensional voxel reconstruction from a series of temporal images obtained using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is proposed. Principal component analysis (PCA) is used to robustly extract the spatial and temporal image features and ...

Negative Immune Regulator TIPE2 Promotes M2 Macrophage Differentiation through the Activation of PI3K-AKT Signaling Pathway

Macrophages play important roles in the regulation of the innate and adaptive immune responses. Classically activated macrophages and alternatively activated macrophages are the two major forms of macrophages and have opposing functionalities. Tumor necrosis factor-α-induced protein 8–2 is expressed primarily by immune cells and negatively regulates type 1 innate and adaptive ...

Nanoparticle targeting of Gram-positive and Gram-negative bacteria for magnetic-based separations of bacterial pathogens

Antimicrobial resistance is a healthcare problem of increasing significance, and there is increasing interest in developing new tools to address bacterial infections. Bacteria-targeting nanoparticles hold promise to improve drug efficacy, compliance, and safety. In addition, nanoparticles can also be used for novel applications, such as bacterial imaging or bioseperations. We here ...

Pharmacogenomics study on cadherin 2 network with regard to HIV infection and methadone treatment outcome

Heroin dependent patients have a high incidence of HIV infection. In contrast to the gene expression method, we developed a systemic correlation analysis method built upon the results of pharmacogenomics study in a methadone maintenance treatment (MMT) cohort consisting of 344 Taiwanese heroin dependent patients. We identified genetic variants and their encoding proteins that may ...

Exploring the structure and function of temporal networks with dynamic graphlets

Motivation: With increasing availability of temporal real-world networks, how to efficiently study these data? One can model a temporal network as a single aggregate static network, or as a series of time-specific snapshots, each being an aggregate static network over the corresponding time window. Then, one can use established methods for static analysis on the resulting aggregate ...

Structural basis of thiol-based regulation of formaldehyde detoxification in H. influenzae by a MerR regulator with no sensor region

Pathogenic bacteria such as Haemophilus influenzae, a major cause of lower respiratory tract diseases, must cope with a range of electrophiles generated in the host or by endogenous metabolism. Formaldehyde is one such compound that can irreversibly damage proteins and DNA through alkylation and cross-linking and interfere with redox homeostasis. Its detoxification operates under ...

Corporatization: An Analysis of Exploitative Branding Practices

This paper seeks to show that the rapid rise of corporatization affects not only first world countries, but also the third world countries. Using examples of the automobile, clothing, and technology industries I prove that corporatization increasingly affects first world countries, as well as the third world countries in a worldwide phenomenon. The paper discusses the growth of ...

Appropriate Use of Telemetry Monitoring in Hospitalized Patients

Esther H. Chen 0 0 E. H. Chen (&) Department of Emergency Medicine, San Francisco General Hospital, University of California , San Francisco , 1001 Potrero Avenue, 1E21, San Francisco, CA 94110, USA

Hepatitis C virus promotes hepatocellular carcinogenesis by targeting TIPE2, a new regulator of DNA damage response

Infection of hepatitis C virus (HCV) is associated with primary hepatocellular carcinoma (HCC). However, its underlying molecular mechanisms remain enigmatic. Tumor necrosis factor-α-induced protein 8-like 2 (TIPE2), a new negative regulator of immunity, plays significant roles in modulating inflammation and tumorigenesis. We hypothesized that TIPE2 might be involved in the ...

Making Abusers Pay: Deterring Patent Litigation by Shifting Attorneys’ Fees

Patent Litigation by Shift ing Attorneys' Fees , 28 Berkeley Tech. L.J. (2013). Available at: - Article 3 MAKING ABUSERS PAY: DETERRING PATENT LITIGATION BY SHIFTING ATTORNEYS’ FEES Emily H. Chen ... ). © 2013 Emily H. Chen . † J.D. Candidate , 2014 , University of California, Berkeley School of Law. 1. See James Bessen , Jennifer Ford & Michael J. Meurer , The Private and Social Costs of Patent Trolls