scientific writing assistance, and Michael Runyon for mentoring. Formal analysis: Anthony J. Weekes, H. James Norton. Funding acquisition: Anthony J. Weekes. Investigation: Anthony J. Weekes, Jaron D. Raper ... Kelly. Methodology: Anthony J. Weekes, H. James Norton. Project administration: Anthony J. Weekes. 24 / 29 Validation: Anthony J. Weekes. Visualization: Anthony J. Weekes. Writing – original draft
Individuals with chronic spinal cord injuries (SCIs) have an increased prevalence of cardiovascular disease (CVD) and associated risk factors compared with age-matched control subjects. Exercise has been shown to improve selected CVD risk factors in individuals with SCI, but using nutrition education as an intervention has not been evaluated in this population. This paper...
Individuals with chronic spinal cord injuries (SCIs) have an increased prevalence of cardiovascular disease (CVD) and associated risk factors compared with age-matched control subjects. Exercise has been shown to improve selected CVD risk factors in individuals with SCI, but using nutrition education as an intervention has not been evaluated in this population. This paper...
Individuals with chronic spinal cord injuries (SCIs) have an increased prevalence of cardiovascular disease (CVD) and associated risk factors compared with age-matched control subjects. Exercise has been shown to improve selected CVD risk factors in individuals with SCI, but using nutrition education as an intervention has not been evaluated in this population. This paper...
Introduction Cathepsin K is a recently discovered cysteine protease which cleaves the triple helical domains of type I to II collagen. It has been shown to be up-regulated in synovial tissue from osteoarthritic and rheumatoid patients, and is a component in normal and nonarthritic cartilage, where it increases with aging. Studies on heart valve development have recently shown...
Zinchenko in:PubMed • Google Scholar Search for H James Norton in:PubMed • Google Scholar Search for Edward N Hanley Jr in:PubMed • Google Scholar Corresponding author Correspondence to Helen E Gruber
Introduction The regulation and elevation in expression of the catabolic matrix metalloproteinases (MMPs) is of high importance in the human intervertebral disc since upregulation of these matrix-degrading enzymes results in matrix destruction associated with disc degeneration. MMP28 (epilysin) is a newly discovered MMP believed to play a role in matrix composition and turnover...
Search for Jane A Ingram in:PubMed • Google Scholar Search for Gretchen L Hoelscher in:PubMed • Google Scholar Search for Natalia Zinchenko in:PubMed • Google Scholar Search for H James Norton in:PubMed
Introduction Brain-derived neurotrophic factor (BDNF) was first identified in the intervertebral disc (IVD) when its molecular upregulation was observed in sections of nucleus pulposus cultured under conditions of increased osmolarity. BDNF is now known to be involved in a number of biologic functions, including regulation of differentiation/survival of sensory neurons...
Scholar Search for H James Norton in:PubMed • Google Scholar Search for Edward N Hanley Jr in:PubMed • Google Scholar Corresponding author Correspondence to Helen E Gruber. Additional information
Background The meniscus is a complex tissue whose cell biology has only recently begun to be explored. Published models rely upon initial culture in the presence of added growth factors. The aim of this study was to test a three-dimensional (3D) collagen sponge microenvironment (without added growth factors) for its ability to provide a microenvironment supportive for meniscal...
The meniscus is a complex tissue whose cell biology has only recently begun to be explored. Published models rely upon initial culture in the presence of added growth factors. The aim of this study was to test a three-dimensional (3D) collagen sponge microenvironment (without added growth factors) for its ability to provide a microenvironment supportive for meniscal cell...
Introduction Calcium crystals exist in the knee joint fluid of up to 65% of osteoarthritis (OA) patients and the presence of these calcium crystals correlates with the radiographic evidence of hyaline cartilaginous degeneration. This study sought to examine calcium deposition in OA meniscus and to investigate OA meniscal cell-mediated calcium deposition. The hypothesis was that...
Search for H James Norton in:PubMed • Google Scholar Search for Natalia Zinchenko in:PubMed • Google Scholar Search for Edward N Hanley Jr in:PubMed • Google Scholar Search for Helen E Gruber in:PubMed
Introduction The biological basis for the avascular state of the intervertebral disc is not well understood. Previous work has suggested that the presence of thrombospondin-1 (TSP-1), a matricellular protein, in the outer annulus reflects a role for this protein in conferring an avascular status to the disc. In the present study we have examined thrombospondin-2 (TSP-2), a...
James Norton 2 0 Department of Orthopaedic Surgery , Cannon Bldg, 3rd floor, Carolinas Medical Center, PO Box 32861, Charlotte, N.C. 28203 , USA 1 University of Southern California and the Orthopaedic
Drug-induced liver injury (DILI) is the most common cause of acute liver failure in the United-States. The aim of the study was to describe serum immune profiles associated with acute DILI, to investigate whether there are profiles associated with clinical features or types of DILI and/or with prognosis, and to assess temporal changes in levels. Twenty-seven immune analytes were...
There is debate concerning use of antibiotic prophylaxis before invasive dental procedures for patients at risk of acquiring distant site infection (DSI). We determined the opinions and practices of infectious disease consultants (IDCs) regarding antimicrobial prophylaxis to prevent DSIs that result from invasive dental procedures by conducting a survey of the 797 members of the...
