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85 papers found.
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Myocyte membrane and microdomain modifications in diabetes: determinants of ischemic tolerance and cardioprotection

Hemal H. Patel John P. Headrick 0 0 School of Medical Science, Griffith University , Southport, QLD 4217 , Australia Cardiovascular disease, predominantly ischemic heart disease (IHD), is the leading

Myocyte membrane and microdomain modifications in diabetes: determinants of ischemic tolerance and cardioprotection

Hemal H. Patel John P. Headrick 0 0 School of Medical Science, Griffith University , Southport, QLD 4217 , Australia Cardiovascular disease, predominantly ischemic heart disease (IHD), is the leading

Myocyte membrane and microdomain modifications in diabetes: determinants of ischemic tolerance and cardioprotection

Hemal H. Patel John P. Headrick 0 0 School of Medical Science, Griffith University , Southport, QLD 4217 , Australia Cardiovascular disease, predominantly ischemic heart disease (IHD), is the leading

Expression of ribosomal proteins in normal and cancerous human prostate tissue

. Resources: Callum Arthurs, Hitendra R. H. Patel, Christopher Thrasivoulou, Aamir Ahmed. Software: Callum Arthurs, Christopher Thrasivoulou, Aamir Ahmed. Supervision: Aamir Ahmed. Validation: Callum Arthurs ... , Rui Henrique, Aamir Ahmed. 12 / 14 Visualization: Callum Arthurs, Aamir Ahmed. Writing ± original draft: Callum Arthurs. Writing ± review & editing: Callum Arthurs, Rui Henrique, Hitendra R. H

Reverse epitope mapping of the E2 glycoprotein in antibody associated hepatitis C virus

The humoral immune system responds to chronic hepatitis C virus (HCV) infection by producing neutralising antibodies (nAb). In this study we generated three HCV pseudoparticles in which E1E2 glycoprotein sequence was targeted by the host humoral immune system. We used patient derived virus free Fabs (VF-Fabs) obtained from HCV genotype 1a (n = 3), genotype 1b (n = 7) and genotype...

IPET study: an FLT-PET window study to assess the activity of the steroid sulfatase inhibitor irosustat in early breast cancer

Background Steroid sulfatase (STS) is involved in oestrogen biosynthesis and irosustat is a first generation, irreversible steroid sulfatase inhibitor. A pre-surgical window-of-opportunity study with irosustat was undertaken in estrogen receptor-positive (ER+) breast cancer to assess the effect of irosustat on tumour cell proliferation as measured by 3′-deoxy-3′-[18F...

Preparation and in vitro/ex vivo evaluation of nanoemulsion for transnasal delivery of paliperidone

Chemistry and Quality Assurance, A. R. College of Pharmacy and G. H. Patel Institute of Pharmacy , Vallabh Vidynagar, Gujarat 388120 , India 1 & Mrunali R. Patel Paliperidone was formulated in mucoadhesive

GW-Bodies and P-Bodies Constitute Two Separate Pools of Sequestered Non-Translating RNAs

Non-translating RNAs that have undergone active translational repression are culled from the cytoplasm into P-bodies for decapping-dependent decay or for sequestration. Organisms that use microRNA-mediated RNA silencing have an additional pathway to remove RNAs from active translation. Consequently, proteins that govern microRNA-mediated silencing, such as GW182/Gw and AGO1, are...

Climate Impacts on Sea Turtle Breeding Phenology in Greece and Associated Foraging Habitats in the Wider Mediterranean Region

Sea turtles are vulnerable to climate change impacts in both their terrestrial (nesting beach) and oceanic habitats. From 1982 to 2012, air and sea surface temperatures at major high use foraging and nesting regions (n = 5) of loggerhead turtles (Caretta caretta) nesting in Greece have steadily increased. Here, we update the established relationships between sea surface...

Skeletal muscle morphology in sarcopenia defined using the EWGSOP criteria: findings from the Hertfordshire Sarcopenia Study (HSS)

Background Sarcopenia is defined as the loss of muscle mass and function with age and is associated with decline in mobility, frailty, falls and mortality. There is considerable interest in understanding the underlying mechanisms. Our aim was to characterise muscle morphology changes associated with sarcopenia among community dwelling older men. Methods One hundred and five men...

Aggregatibacter aphrophilus pacemaker endocarditis: a case report

Background Aggregatibacter bacteria are a rare cause of endocarditis in adults. They are part of a group of organisms known as HACEK – Haemophilus, Aggregatibacter, Cardiobacter, Eikenella, and Kingella. Among these organisms, several Haemophilus species have been reclassified under the genus Aggregatibacter. Very few cases of Aggregatibacter endocarditis in patients with...

Evolutionary crossroads in developmental biology

0 Nipam H. Patel Editor, Development - Currently, most developmental biologists work on one or more of a relatively small number of experimental systems, such as Arabidopsis thaliana, Drosophila

Cellular Size as a Means of Tracking mTOR Activity and Cell Fate of CD4+ T Cells upon Antigen Recognition

mTOR is a central integrator of metabolic and immunological stimuli, dictating immune cell activation, proliferation and differentiation. In this study, we demonstrate that within a clonal population of activated T cells, there exist both mTORhi and mTORlo cells exhibiting highly divergent metabolic and immunologic functions. By taking advantage of the role of mTOR activation in...

Exosomes Released from Breast Cancer Carcinomas Stimulate Cell Movement

For metastasis to occur cells must communicate with to their local environment to initiate growth and invasion. Exosomes have emerged as an important mediator of cell-to-cell signalling through the transfer of molecules such as mRNAs, microRNAs, and proteins between cells. Exosomes have been proposed to act as regulators of cancer progression. Here, we study the effect of...

A Transcriptomic Analysis of Cave, Surface, and Hybrid Isopod Crustaceans of the Species Asellus aquaticus

Cave animals, compared to surface-dwelling relatives, tend to have reduced eyes and pigment, longer appendages, and enhanced mechanosensory structures. Pressing questions include how certain cave-related traits are gained and lost, and if they originate through the same or different genetic programs in independent lineages. An excellent system for exploring these questions is the...

Should providers encourage realistic weight expectations and satisfaction with lost weight in commercial weight loss programs? a preliminary study

Background Attrition is a problem among patients who participate in commercial weight loss programs. One possible explanation is that if patients are unable to reach a weight that they expect to achieve, they may be more likely to drop out of treatment. This study investigated variables associated with attrition among 30 obese patients who completed a liquid meal replacement...

Effect of a Modified Saquinavir/Ritonavir Dosing Regimen with Lower Dose Lead-In Phase on QTc Interval, Pharmacokinetics, Antiviral Activity and Safety in Treatment-Naïve HIV-1-Infected Patients

Background Saquinavir/ritonavir (1000/100 mg twice daily [BID]) is associated with dose- and exposure-dependent prolongation of the QT interval. The QT risk is considered higher during the first week of therapy, when saquinavir peak exposure has been observed. A modified regimen with a lower dose lead-in phase may reduce potential saquinavir-/ritonavir-induced QT prolongations...

Collaborating in Higher Education: Improving Pedagogical Practice

We presuppose that thoughtful pedagogical practice should be included in higher education as much as it is in K–12 classrooms. Effective and purposeful collaborative efforts provide faculty with opportunities to better develop their pedagogical practice. This article describes how collaboration has been utilized at the university level between a full-time faculty member and a K...

Consequences of Low Dose Ionizing Radiation Exposure on the Hippocampal Microenvironment

The response of the brain to irradiation is complex, involving a multitude of stress inducible pathways that regulate neurotransmission within a dynamic microenvironment. While significant past work has detailed the consequences of CNS radiotherapy following relatively high doses (≥ 45 Gy), few studies have been conducted at much lower doses (≤ 2 Gy), where the response of the...