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Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD

and mouse experiment. 11 / 14 Author Contributions Conceptualization: Hai B. Tran, Stuart M. Pitson, Sandra Hodge. Data curation: Hai B. Tran, Sandra Hodge. Formal analysis: Hai B. Tran, Tung Thanh ... Truong, Rhys Hamon, Melissa R. Pitman, Sandra Hodge. Funding acquisition: Tung Thanh Truong, Stuart M. Pitson, Paul N. Reynolds, Sandra Hodge. Investigation: Hai B. Tran, Hubertus Jersmann, Tung Thanh

Lymphocyte senescence in COPD is associated with loss of glucocorticoid receptor expression by pro-inflammatory/cytotoxic lymphocytes

Background Glucocorticoid (GC) resistance is a major barrier in COPD treatment. We have shown increased expression of the drug efflux pump, Pgp1 in cytotoxic/pro-inflammatory lymphocytes in COPD. Loss of lymphocyte co-stimulatory molecule CD28 (lymphocyte senescence) was associated with a further increase in their pro-inflammatory/cytotoxic potential and resistance to GC. We...

Oxidative Stress Decreases Functional Airway Mannose Binding Lectin in COPD

We have previously established that a defect in the ability of alveolar macrophages (AM) to phagocytose apoptotic cells (efferocytosis) and pathogens is a potential therapeutic target in COPD. We further showed that levels of mannose binding lectin (MBL; required for effective macrophage phagocytic function) were reduced in the airways but not circulation of COPD patients. We...

Zinc and Zinc Transporters in Macrophages and Their Roles in Efferocytosis in COPD

Our previous studies have shown that nutritional zinc restriction exacerbates airway inflammation accompanied by an increase in caspase-3 activation and an accumulation of apoptotic epithelial cells in the bronchioles of the mice. Normally, apoptotic cells are rapidly cleared by macrophage efferocytosis, limiting any secondary necrosis and inflammation. We therefore hypothesized...