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Anti-tumor Study of Chondroitin Sulfate-Methotrexate Nanogels

Self-assembly nanogels (NGs) were formed by bioconjugating methotrexate (MTX) with chondroitin sulfate (CS). MTX-CS NGs can greatly enhance the solubility and improve the delivery efficacy of MTX due to the CD44 binding property of CS. Vivo experiments revealed that MTX-CS NGs showed less toxicity than MTX. MTX-CS NGs can improve the anti-tumor effect while reducing the side...

Low-pass whole-genome sequencing in clinical cytogenetics: a validated approach

. AffiliationsBGI-Shenzhen, Shenzhen, ChinaZirui Dong, Haixiao Chen, Jinjin Xu, Shanshan Yu, Fang Chen, Hui Jiang & Wei WangDepartment of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong ... journals • PubMed • Google ScholarSearch for Haixiao Chen in:Nature Research journals • PubMed • Google ScholarSearch for Jinjin Xu in:Nature Research journals • PubMed • Google ScholarSearch for Qi Tian