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Effects of 99mTc-TRODAT-1 drug template on image quantitative analysis

facilitate the construction of radiotracer templates. Supporting information S1 Table. SUR values of all subjects. (XLSX) Author Contributions Conceptualization: Cheng-Han Wu, Bang-Hung Yang. Formal ... analysis: Cheng-Han Wu. Investigation: Cheng-Han Wu. Methodology: Cheng-Han Wu, Bang-Hung Yang. Project administration: Bang-Hung Yang, Jyh-Cheng Chen. Resources: Bang-Hung Yang, Yuan-Hwa Chou, Shyh-Jen

Horseradish Peroxidase-Encapsulated Hollow Silica Nanospheres for Intracellular Sensing of Reactive Oxygen Species

Reactive oxygen species (ROS) have crucial roles in cell signaling and homeostasis. Overproduction of ROS can induce oxidative damage to various biomolecules and cellular structures. Therefore, developing an approach capable of monitoring and quantifying ROS in living cells is significant for physiology and clinical diagnoses. Some cell-permeable fluorogenic probes developed are...

Changes in Skeletal Muscle and Body Weight on Sleeping Beauty Transposon-Mediated Transgenic Mice Overexpressing Pig mIGF-1

Insulin-like growth factor (IGF-I) is an important growth factor in mammals, but the functions of the local muscle-specific isoform of insulin-like growth factor 1 (mIGF-1) to skeletal muscle development have rarely been reported. To determine the effect of pig mIGF-1 on body development and muscle deposition in vivo and to investigate the molecular mechanisms, the transgenic...

Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs

episodes (MELAS). We engineered - Yi Yang, Han Wu, and Xiangjin Kang have contributed equally to this work. mitochondrial-targeted transcription activator-like effector nucleases (mitoTALENs) and ... national guidelines for the care and use of laboratory animals were followed. Yi Yang, Han Wu, Xiangjin Kang, Yanhui Liang, Ting Lan, Tianjie Li, Tao Tan, Jiangyun Peng, Quanjun Zhang, Geng An, Yali Liu

Down-regulation of metabolic proteins in hepatocellular carcinoma with portal vein thrombosis

HsiuY‑ing Hsu 0 Tsung‑Han Wu 0 Kun‑Ming Chan 0 0 Division of Liver and Transplantation Surgery, Department of General Surgery, Chang‐Gung Memorial Hospital, Chang ‐ Gung University College of Medicine , 5

Enhanced Optoelectronic Conversion Efficiency of CdSe/ZnS Quantum Dot/Graphene/Silver Nanowire Hybrid Thin Films

In this study, we prepared the reduced graphene oxide (rGO)-CdSe/ZnS quantum dots (QDs) hybrid films on a three-layer scaffold that the QD layer was sandwiched between the two rGO layers. The photocurrent was induced by virtue of the facts that the rGO quenched the photoluminescence of QDs and transferred the excited energy. The quenching mechanism was attributed to the surface...

Acupuncture lowering blood pressure for secondary prevention of stroke: a study protocol for a multicenter randomized controlled trial

Stroke is the prime cause of morbidity and mortality in the general population, and hypertension will increase the recurrence and mortality of stroke. We report a protocol of a pragmatic randomized controlled trial (RCT) using blood pressure (BP)-lowering acupuncture add-on treatment to treat patients with hypertension and stroke. This is a large-scale, multicenter, subject...

Seeking Common Ground While Keeping Differences: “Using the Case of Cross-Strait Relations as a Case”

Charles Chong-han Wu I. INTRODUCTION * Charles Chong-han Wu is Assistant Professor of Department of Government and International Relations at the Hong Kong Baptist University-United International College

Diffusion tensor tractography reveals muscle reconnection during axolotl limb regeneration

Axolotls have amazing ability to regenerate their lost limbs. Our previous works showed that after amputation the remnant muscle ends remained at their original location whilst sending satellite cells into the regenerating parts to develop into early muscle fibers in the late differentiation stage. The parental and the newly formed muscle fibers were not connected until very late...

Andrographis paniculata (Chuān Xīn Lián) for symptomatic relief of acute respiratory tract infections in adults and children: A systematic review and meta-analysis

Introduction Antimicrobial resistance (AMR) is a substantial threat to public health. Safe and effective alternatives are required to reduce unnecessary antibiotic prescribing. Andrographis Paniculata (A. Paniculata, Chuān Xīn Lián) has traditionally been used in Indian and Chinese herbal medicine for cough, cold and influenza, suggesting a role in respiratory tract infections...

Increased heterogeneity of brain perfusion is an early marker of central nervous system involvement in antiphospholipid antibody carriers

Objective The non-criteria neuropsychiatric manifestations of antiphospholipid syndrome include headache, dizziness, vertigo, seizure, depression and psychosis. There were still no objective methods qualified to detect the early central nervous system involvement in non-criteria antiphospholipid syndrome. We evaluated the effectiveness of Tc-99m ECD SPECT in assessing circulatory...

Dairy products intake and cancer mortality risk: a meta-analysis of 11 population-based cohort studies

Background Dairy products are major components of daily diet and the association between consumption of dairy products and public health issues has captured great attention. In this study, we conducted a meta-analysis to investigate the association between dairy products intake and cancer mortality risk. Methods After a literature search in PubMed and EMBASE, 11 population-based...

Membrane Transfer from Mononuclear Cells to Polymorphonuclear Neutrophils Transduces Cell Survival and Activation Signals in the Recipient Cells via Anti-Extrinsic Apoptotic and MAP Kinase Signaling Pathways

The biological significance of membrane transfer (trogocytosis) between polymorphonuclear neutrophils (PMNs) and mononuclear cells (MNCs) remains unclear. We investigated the biological/immunological effects and molecular basis of trogocytosis among various immune cells in healthy individuals and patients with active systemic lupus erythematosus (SLE). By flow cytometry, we...

The Rat microRNA body atlas; Evaluation of the microRNA content of rat organs through deep sequencing and characterization of pancreas enriched miRNAs as biomarkers of pancreatic toxicity in the rat and dog

Background MicroRNAs (miRNA) are ~19–25 nucleotide long RNA molecules that fine tune gene expression through the inhibition of translation or degradation of the mRNA through incorporation into the RNA induced silencing complex (RISC). MicroRNAs are stable in the serum and plasma, are detectable in a wide variety of body fluids, are conserved across veterinary species and humans...

Sjögren’s Syndrome Antigen B Acts as an Endogenous Danger Molecule to Induce Interleukin-8 Gene Expression in Polymorphonuclear Neutrophils

Background Sjögren’s syndrome antigen B is expressed in the nucleus and surface membrane of human polymorphonuclear neutrophils and is released after cell death. However, its biological role is not clear. This study is aimed to investigate the effect of Sjögren’s syndrome antigen B on human polymorphonuclear neutrophils. Methods Human recombinant Sjögren’s syndrome antigen B...

The Interaction Affinity between Vascular Cell Adhesion Molecule-1 (VCAM-1) and Very Late Antigen-4 (VLA-4) Analyzed by Quantitative FRET

Very late antigen-4 (VLA-4), a member of integrin superfamily, interacts with its major counter ligand vascular cell adhesion molecule-1 (VCAM-1) and plays an important role in leukocyte adhesion to vascular endothelium and immunological synapse formation. However, irregular expressions of these proteins may also lead to several autoimmune diseases and metastasis cancer. Thus...

Pure electron-electron dephasing in percolative aluminum ultrathin film grown by molecular beam epitaxy

We have successfully grown ultrathin continuous aluminum film by molecular beam epitaxy. This percolative aluminum film is single crystalline and strain free as characterized by transmission electron microscopy and atomic force microscopy. The weak anti-localization effect is observed in the temperature range of 1.4 to 10 K with this sample, and it reveals that, for the first...

Long-Duration Muscle Dedifferentiation during Limb Regeneration in Axolotls

Although still debated, limb regeneration in salamanders is thought to depend on the dedifferentiation of remnant tissue occurring early after amputation and generating the progenitor cells that initiate regeneration. This dedifferentiation has been demonstrated previously by showing the fragmentation of muscle fibers into mononucleated cells and by revealing the contribution of...

Resveratrol ameliorates myocardial fibrosis by inhibiting ROS/ERK/TGF-β/periostin pathway in STZ-induced diabetic mice

Background Myocardial fibrosis is an essential hallmark of diabetic cardiomyopathy (DCM) contributing to cardiac dysfunctions. Resveratrol, an antioxidant, exerts its anti-fibrotic effect via inhibition of oxidative stress, while the underlying molecular mechanism remains largely elusive. Periostin, a fibrogenesis matricellular protein, has been shown to be associated with...

Risk of psychiatric disorders following trigeminal neuralgia: a nationwide population-based retrospective cohort study

Background TN is one of the most common causes of facial pain. A higher prevalence of psychiatric co-morbidities, especially depressive disorder, has been proven in patients with TN; however, a clear temporal-causal relationship between TN and specific psychiatric disorders has not been well established. We performed a nationwide population-based retrospective cohort study to...