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On the security of consumer wearable devices in the Internet of Things

S1_File.xlsx. (XLSX) Author Contributions Conceptualization: Hasan Tahir. Data curation: Hasan Tahir. Formal analysis: Hasan Tahir, Ruhma Tahir. 19 / 21 Funding acquisition: Klaus McDonald-Maier ... . Investigation: Ruhma Tahir. Methodology: Hasan Tahir, Ruhma Tahir, Klaus McDonald-Maier. Project administration: Ruhma Tahir, Klaus McDonald-Maier. Resources: Klaus McDonald-Maier. Software: Hasan Tahir, Klaus

Secukinumab in Active Rheumatoid Arthritis after Anti-TNFα Therapy: A Randomized, Double-Blind Placebo-Controlled Phase 3 Study

Introduction ‘REASSURE’ (NCT01377012), a phase 3 study, evaluated the efficacy and safety of secukinumab in patients with active rheumatoid arthritis (RA) who had an inadequate response to, or intolerance of, tumor necrosis factor inhibitors (TNF-inhibitors). Methods A total of 637 patients were randomized (1:1:1) to receive intravenous secukinumab 10 mg/kg (baseline, weeks 2 and...

Stabilization of Bilateral Progressive Rheumatoid Corneal Melt with Infliximab

Purpose. To report the use of infliximab in the rapid stabilization of a case of progressive, bilateral rheumatoid peripheral ulcerative keratitis (PUK) that failed to respond to conventional immunosuppressive therapy. Methods. A single interventional case report. Results. A patient with rheumatoid arthritis presented with bilateral PUK following a 2-month history of ocular...

Profiling the HER3/PI3K Pathway in Breast Tumors Using Proximity-Directed Assays Identifies Correlations between Protein Complexes and Phosphoproteins

Background The identification of patients for targeted antineoplastic therapies requires accurate measurement of therapeutic targets and associated signaling complexes. HER3 signaling through heterodimerization is an important growth-promoting mechanism in several tumor types and may be a principal resistance mechanism by which EGFR and HER2 expressing tumors elude targeted...