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Search: authors:"Hee-Cheol Kim"

14 papers found.
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Duality walls and defects in 5d \( \mathcal{N}=1 \) theories

We propose an explicit description of “duality walls” which encode at low energy the global symmetry enhancement expected in the UV completion of certain five-dimensional gauge theories. The proposal is supported by explicit localization computations and implies that the instanton partition function of these theories satisfies novel and unexpected integral equations.

Surface defects and instanton partition functions

We study the superconformal index of five-dimensional SCFTs and the sphere partition function of four-dimensional gauge theories with eight supercharges in the presence of co-dimension two half-BPS defects. We derive a prescription which is valid for defects which can be given a “vortex construction”, i.e. can be defined by RG flow from vortex configurations in a larger theory. We ...

Line defects and 5d instanton partition functions

We consider certain line defect operators in five-dimensional SUSY gauge theories, whose interaction with the self-dual instantons is described by 1d ADHM-like gauged quantum mechanics constructed by Tong and Wong. The partition function in the presence of these operators is known to be a generating function of BPS Wilson loops in skew symmetric tensor representations of the gauge ...

The superconformal index of the (2,0) theory with defects

We compute the supersymmetric partition function of the six-dimensional (2, 0) theory of type A N −1 on S 1 × S 5 in the presence of both codimension two and codimension four defects. We concentrate on a limit of the partition function depending on a single parameter. From the allowed supersymmetric configurations of defects we find a precise match with the characters of ...

Supersymmetric Casimir energy and the anomaly polynomial

We conjecture that for superconformal field theories in even dimensions, the supersymmetric Casimir energy on a space with topology S 1 × S D−1 is equal to an equivariant integral of the anomaly polynomial. The equivariant integration is defined with respect to the Cartan subalgebra of the global symmetry algebra that commutes with a given supercharge. We test our proposal ...

Defects and quantum Seiberg-Witten geometry

We study the Nekrasov partition function of the five dimensional U(N) gauge theory with maximal supersymmetry on ℝ4 × S 1 in the presence of codimension two defects. The codimension two defects can be described either as monodromy defects, or by coupling to a certain class of three dimensional quiver gauge theories on ℝ2 × S 1. We explain how these computations are connected with ...

Factorization of the 3d superconformal index

We prove that 3d superconformal index for general \( \mathcal{N} \) = 2 U(N) gauge group with fundamentals and anti-fundmentals with/without Chern-Simons terms is factorized into vortex and anti-vortex partition function. We show that for simple cases, 3d vortex partition function coincides with a suitable topological open string partition function. We provide much more elegant ...

Topological strings and 5d T N partition functions

We evaluate the Nekrasov partition function of 5d gauge theories engineered by webs of 5-branes, using the refined topological vertex on the dual Calabi-Yau three-folds. The theories include certain non-Lagrangian theories such as the T N theory. The refined topological vertex computation generically contains contributions from decoupled M2-branes which are not charged under the 5d ...

The impact of KRAS mutations on prognosis in surgically resected colorectal cancer patients with liver and lung metastases: a retrospective analysis

Background KRAS mutations are common in colorectal cancer (CRC). The role of KRAS mutation status as a prognostic factor remains controversial, and most large population-based cohorts usually consist of patients with non-metastatic CRC. We evaluated the impact of KRAS mutations on the time to recurrence (TTR) and overall survival (OS) in patients with metastatic CRC who underwent ...

Activated cMET and IGF1R-Driven PI3K Signaling Predicts Poor Survival in Colorectal Cancers Independent of KRAS Mutational Status

Background Oncogenic mutational analysis provides predictive guidance for therapeutics such as anti-EGFR antibodies, but it is successful only for a subset of colorectal cancer (CRC) patients. Method A comprehensive molecular profiling of 120 CRC patients, including 116 primary, 15 liver metastasis, and 1 peritoneal seeding tissue samples was performed to identify the relationship ...

Alcohol dehydrogenase, iron containing, 1 promoter hypermethylation associated with colorectal cancer differentiation

Background The aberrant methylation of CpG islands in the promoter is associated with colorectal cancer (CRC) carcinogenesis. In our previous study, the promoter of alcohol dehydrogenase, iron containing, 1 (ADHFE1) was most highly methylated in CRC compared to normal colorectal mucosa. In this study, we examined the expression and function of the ADHFE1 in CRC. Methods We examined ...

Metastasis of Neuroendocrine Tumors Are Characterized by Increased Cell Proliferation and Reduced Expression of the ATM Gene

Purpose Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare group of tumors with a wide spectrum of clinical behavior. However, there are no known clinically relevant biomarkers to predict metastasis. Experimental Design To investigate differential gene expression signatures of metastatic vs non-metastatic NETs, we studied cell cycle regulatory genes in 19 metastatic ...

Palliative radiotherapy in patients with a symptomatic pelvic mass of metastatic colorectal cancer

Background To evaluate the palliative role of radiotherapy (RT) and define the effectiveness of chemotherapy combined with palliative RT (CCRT) in patients with a symptomatic pelvic mass of metastatic colorectal cancer. Methods From August 1995 to December 2007, 80 patients with a symptomatic pelvic mass of metastatic colorectal cancer were treated with palliative RT at Samsung ...