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17 papers found.
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Two-loop supersymmetric QCD and half-maximal supergravity amplitudes

Using the duality between color and kinematics, we construct two-loop four-point scattering amplitudes in \( \mathcal{N}=2 \) super-Yang-Mills (SYM) theory coupled to N f fundamental hypermultiplets. Our results are valid in D ≤ 6 dimensions, where the upper bound corresponds to six-dimensional chiral \( \mathcal{N}=\left(1,0\right) \) SYM theory. By exploiting a close connection ...

Explicit formulae for Yang-Mills-Einstein amplitudes from the double copy

Using the double-copy construction of Yang-Mills-Einstein theories formulated in our earlier work, we obtain compact presentations for single-trace Yang-Mills-Einstein tree amplitudes with up to five external gravitons and an arbitrary number of gluons. These are written as linear combinations of color-ordered Yang-Mills trees, where the coefficients are given by ...

Spontaneously broken Yang-Mills-Einstein supergravities as double copies

Color/kinematics duality and the double-copy construction have proved to be systematic tools for gaining new insight into gravitational theories. Extending our earlier work, in this paper we introduce new double-copy constructions for large classes of spontaneously-broken Yang-Mills-Einstein theories with adjoint Higgs fields. One gauge-theory copy entering the construction is a ...

Color-kinematics duality for QCD amplitudes

We show that color-kinematics duality is present in tree-level amplitudes of quantum chromodynamics with massive flavored quarks. Starting with the color structure of QCD, we work out a new color decomposition for n-point tree amplitudes in a reduced basis of primitive amplitudes. These primitives, with k quark-antiquark pairs and (n − 2k) gluons, are taken in the (n − 2)!/k! Melia ...

Pure gravities via color-kinematics duality for fundamental matter

We give a prescription for the computation of loop-level scattering amplitudes in pure Einstein gravity, and four-dimensional pure supergravities, using the color-kinematics duality. Amplitudes are constructed using double copies of pure (super-)Yang-Mills parts and additional contributions from double copies of fundamental matter, which are treated as ghosts. The ...

Priming increases the anti-tumor effect and therapeutic window of 177Lu-octreotate in nude mice bearing human small intestine neuroendocrine tumor GOT1

Background 177Lu-[DOTA0, Tyr3]-octreotate (177Lu-octreotate) is used for treatment of patients with somatostatin receptor (SSTR) expressing neuroendocrine tumors. However, complete tumor remission is rarely seen, and optimization of treatment protocols is needed. In vitro studies have shown that irradiation can up-regulate the expression of SSTR1, 2 and 5, and increase ...

The relationship between exercise induced bronchial obstruction and health related quality of life in female and male adolescents from a general population

Background Previous studies have observed that exercise-induced bronchoconstriction (EIB) is more common and more strongly related to exercise related breathing problems in female adolescents than male adolescents. However, few studies have investigated the association between EIB and health related quality of life (HRQoL) from a gender perspective. The aim of this study was to ...

Guest editorial: event-based control and optimization

dynamic systems (DEDSs) and simulation-based performance evaluation and optimization of complex systems. Karl Henrik Johansson is Director of the KTH ACCESS Linnaeus Centre and Professor at the School of

Scattering amplitudes in \( \mathcal{N}=2 \) Maxwell-Einstein and Yang-Mills/Einstein supergravity

We expose a double-copy structure in the scattering amplitudes of the generic Jordan family of \( \mathcal{N}=2 \) Maxwell-Einstein and Yang-Mills/Einstein supergravity theories in four and five dimensions. The Maxwell-Einstein supergravity amplitudes are obtained through the color/kinematics duality as a product of two gauge-theory factors; one originating from pure \( ...

On three-algebra and bi-fundamental matter amplitudes and integrability of supergravity

We explore tree-level amplitude relations for SU(N) × SU(M) bi-fundamental matter theories. Embedding the group-theory structure in a Lie three-algebra, we derive Kleiss-Kuijf-like relations for bi-fundamental matter theories in general dimension. We investigate the three-algebra color-kinematics duality for these theories. Unlike the Yang-Mills two-algebra case, the three-algebra ...

Prediction of Chemical Respiratory Sensitizers Using GARD, a Novel In Vitro Assay Based on a Genomic Biomarker Signature

: The authors have the following interests: Co-author Henrik Johansson has been employed by SenzaGen AB since July 2014. The authors have filed a patent related to material pertinent to this article

Evaluation of high throughput gene expression platforms using a genomic biomarker signature for prediction of skin sensitization

Background Allergic contact dermatitis (ACD) develops upon exposure to certain chemical compounds termed skin sensitizers. To reduce the occurrence of skin sensitizers, chemicals are regularly screened for their capacity to induce sensitization. The recently developed Genomic Allergen Rapid Detection (GARD) assay is an in vitro alternative to animal testing for identification of ...

Genomic Allergen Rapid Detection In-House Validation—A Proof of Concept

Chemical sensitization is an adverse immunologic response to chemical substances, inducing hypersensitivity in exposed individuals. Identifying chemical sensitizers is of great importance for chemical, pharmaceutical, and cosmetic industries, in order to prevent the use of sensitizers in consumer products. Historically, chemical sensitizers have been assessed mainly by in vivo ...

Skin sensitizers differentially regulate signaling pathways in MUTZ-3 cells in relation to their individual potency

Background Due to the recent European legislations posing a ban of animal tests for safety assessment within the cosmetic industry, development of in vitro alternatives for assessment of skin sensitization is highly prioritized. To date, proposed in vitro assays are mainly based on single biomarkers, which so far have not been able to classify and stratify chemicals into subgroups, ...

Differentially Expressed Proteins in Malignant and Benign Adrenocortical Tumors

We have compared the microsomal protein composition of eight malignant and six benign adrenocortical tumors with proteomic methods. IGF2 had increased level in the malignant tumors, confirming previous microarray studies on the same material. Aldolase A, a glycolytic enzyme, also showed increased levels in the malignant tissue compared to the benign. Additionally, several proteins ...

The HY5-PIF Regulatory Module Coordinates Light and Temperature Control of Photosynthetic Gene Transcription

The ability to interpret daily and seasonal alterations in light and temperature signals is essential for plant survival. This is particularly important during seedling establishment when the phytochrome photoreceptors activate photosynthetic pigment production for photoautotrophic growth. Phytochromes accomplish this partly through the suppression of PHYTOCHROME INTERACTING ...

A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests

Background Allergic contact dermatitis is an inflammatory skin disease that affects a significant proportion of the population. This disease is caused by an adverse immune response towards chemical haptens, and leads to a substantial economic burden for society. Current test of sensitizing chemicals rely on animal experimentation. New legislations on the registration and use of ...