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Search: authors:"Henrique Lemos"

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Carbidopa, a drug in use for management of Parkinson disease inhibits T cell activation and autoimmunity

National Institutes of Health grant R01DK103576 to NS. Author Contributions Conceptualization: Nagendra Singh. Data curation: Huabin Zhu, Henrique Lemos, Brinda Bhatt, Bianca N. Islam, Ashish Gurav, Lei ... . NeuroImmunoModulation. 2001 ; 9 ( 1 ): 11 . https://doi.org/10.1159/000049004 20. Henrique Lemos LH , Chandler Phillip R., Mohamed Eslam , Souza Guilherme R. , Li Lingqian , Pacholczyk Gabriela , et al. Activation of the

Leishmania major Attenuates Host Immunity by Stimulating Local Indoleamine 2,3-Dioxygenase Expression

Inflammation stimulates immunity but can create immune privilege in some settings. Here, we show that cutaneous Leishmania major infection stimulated expression of the immune regulatory enzyme indoleamine 2,3 dioxygenase (IDO) in local lymph nodes. Induced IDO attenuated the T cell stimulatory functions of dendritic cells and suppressed local T cell responses to exogenous and ...