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Search: authors:"Hideto Obata"

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Application of the COOP/WONCA charts to aged patients with chronic obstructive pulmonary disease: a comparison between Japanese and Chinese populations

Background The prevalence of chronic obstructive pulmonary disease (COPD) is similar in Japan and China and is increasing due to high rates of smoking in these countries. Reducing COPD is an important public health issue. The goals of this study were to verify the reliability and validity of the Japanese version of the COOP/WONCA charts, a tool for measuring health status, and to...

c-Myc gene single-strand binding protein-1, MSSP-1, suppresses transcription of α-smooth muscle actin gene in chicken visceral smooth muscle cells

The expression of α-smooth muscle actin is coordinately regulated by positive and negative cis-elements in the promoter region. Although cis-elements and trans-acting factors involved in the positive regulation of the α-smooth muscle (α-SM) actin gene have been well characterized, details of negative regulation remain unclear. In functional analyses using cultured gizzard smooth...