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Impact of pre-sarcopenia in sorafenib treatment for advanced hepatocellular carcinoma

prognostic factors. Therefore, pre-sarcopenia could be the target of intervention to improve prognosis. Author Contributions Conceptualization: Hitomi Takada, Masayuki Kurosaki, Hiroyuki Nakanishi, Yuka

Quantification of sympathetic hyperinnervation and denervation after myocardial infarction by three-dimensional assessment of the cardiac sympathetic network in cleared transparent murine hearts

Iida, Issei Komuro. Writing ± review & editing: Teruki Yokoyama, Jong-Kook Lee, Keiko Miwa, Tobias Opthof, Satoki Tomoyama, Hiroyuki Nakanishi, Akira Yoshida, Haruyo Yasui, Tadatsune Iida, Shigeru

Prediction of diuretic response to tolvaptan by a simple, readily available spot urine Na/K ratio

Background Tolvaptan is vasopressin type 2 receptor antagonist that inhibits water reabsorption. It is used in combination with standard diuretics to treat ascites unresponsive to standard diuretic therapy or hyponatremia because of liver cirrhosis. This study evaluated the effectiveness and safety of tolvaptan in clinical practice and aimed to determine the factors related to...

Correction: Elastin Fiber Accumulation in Liver Correlates with the Development of Hepatocellular Carcinoma

Yoshida Tsuguru Hayashi Konomi Kuwabara Kenta Takaura Natsuko Nakakuki Hitomi Takada Nobuharu Tamaki Shoko Suzuki Hiroyuki Nakanishi Kaoru Tsuchiya Jun Itakura Yuka Takahashi Akinori Hashiguchi Michiie

Resistance-Associated NS5A Variants of Hepatitis C Virus Are Susceptible to Interferon-Based Therapy

Background & Aims The presence of resistance-associated variants (RAVs) of hepatitis C virus (HCV) attenuates the efficacy of direct acting antivirals (DAAs). The objective of this study was to characterize the susceptibility of RAVs to interferon-based therapy. Methods Direct and deep sequencing were performed to detect Y93H RAV in the NS5A region. Twenty nine genotype 1b...

Genetic Polymorphisms of IL28B and PNPLA3 Are Predictive for HCV Related Rapid Fibrosis Progression and Identify Patients Who Require Urgent Antiviral Treatment with New Regimens

The assessment of individual risk of fibrosis progression in patients with chronic hepatitis C is an unmet clinical need. Recent genome-wide association studies have highlighted several genetic alterations as predictive risk factors of rapid fibrosis progression in chronic hepatitis C. However, most of these results require verification, and whether the combined use of these...

Pretreatment Gastric Lavage Reduces Postoperative Bleeding after Endoscopic Submucosal Dissection for Gastric Neoplasms

Aim For patients receiving endoscopic submucosal dissection (ESD), there is urgent need pertaining to the prevention of postoperative bleeding. We conducted a retrospective propensity score-matched study that evaluated whether pre-ESD gastric lavage prevents postoperative bleeding after ESD for gastric neoplasms. Methods From September 2002 to October 2015, the 760 consecutive...

Elastin Fiber Accumulation in Liver Correlates with the Development of Hepatocellular Carcinoma

Background & Aims The fibrosis stage, which is evaluated by the distribution pattern of collagen fibers, is a major predictor for the development of hepatocellular carcinoma (HCC) for patients with hepatitis C. Meanwhile, the role of elastin fibers has not yet been elucidated. The present study was conducted to determine the significance of quantifying both collagen and elastin...

Association Study of a Functional Variant on ABCG2 Gene with Sunitinib-Induced Severe Adverse Drug Reaction

Sunitinib is a tyrosine kinase inhibitor and used as the first-line treatment for advanced renal cell carcinoma (RCC). Nevertheless, inter-individual variability of drug’s toxicity was often observed among patients who received sunitinib treatment. This study is to investigate the association of a functional germline variant on ABCG2 that affects the pharmacokinetics of sunitinib...

Innovative Delivery of siRNA to Solid Tumors by Super Carbonate Apatite

RNA interference (RNAi) technology is currently being tested in clinical trials for a limited number of diseases. However, systemic delivery of small interfering RNA (siRNA) to solid tumors has not yet been achieved in clinics. Here, we introduce an in vivo pH-sensitive delivery system for siRNA using super carbonate apatite (sCA) nanoparticles, which is the smallest class of...

Nectin and afadin: novel organizers of intercellular junctions

Yoshimi Takai ) 0 Hiroyuki Nakanishi 0 0 Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine/Faculty of Medicine , Suita 565-0871 , Japan - The cadherin

Localization of mLin-7 at nectin-based cell–cell junctions

In C. elegans, lin-7 as well as lin-2/lin-10 is involved in the proper localization of the LET-23 receptor tyrosine kinase that regulates vulval induction. The mammalian homologue, mLin-7, forms a ternary complex with the mammalian homologues of LIN-2 and LIN-10 and localizes at cell–cell junctions in epithelial cells, but the mechanism of this localization of mLin-7 is unknown...

Different behavior of l-Afadin and Neurabin-II during the formation and destruction of cell – cell adherens junction

Nakanishi, Kenichi Takahashi, Kenji Mandai, Masako Miyahara & Ayako Satoh AuthorsSearch for Toshiaki Sakisaka in:Nature Research journals • PubMed • Google ScholarSearch for Hiroyuki Nakanishi in:Nature

Involvement of nectin in the localization of junctional adhesion molecule at tight junctions

, JapanAtsunori Fukuhara, Kenji Irie, Hiroyuki Nakanishi, Kyoji Takekuni, Tomomi Kawakatsu, Wataru Ikeda, Akio Yamada, Tatsuo Katata, Tomoyuki Honda, Tatsuhiro Sato, Kazuya Shimizu & Yoshimi TakaiDepartment of ... ScholarSearch for Kenji Irie in:Nature Research journals • PubMed • Google ScholarSearch for Hiroyuki Nakanishi in:Nature Research journals • PubMed • Google ScholarSearch for Kyoji Takekuni in:Nature Research