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29 papers found.
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Anomaly matching on the Higgs branch

We point out that we can almost always determine by the anomaly matching the full anomaly polynomial of a supersymmetric theory in 2d, 4d or 6d if we assume that its Higgs branch is the one-instanton moduli space of some group G. This method not only provides by far the simplest method to compute the central charges of known theories of this class, e.g. 4d E 6,7,8 theories of...

Small instanton transitions for M5 fractions

M5-branes on an ADE singularity are described by certain six-dimensional “conformal matter” superconformal field theories. Their Higgs moduli spaces contain information about various dynamical processes for the M5s; however, they are not directly accessible due to the lack of a Lagrangian formulation. Using anomaly matching, we compute their dimensions. The result implies that M5...

Anomaly of strings of 6d \( \mathcal{N}=\left(1,0\right) \) theories

We obtain the anomaly polynomial of strings of general 6d \( \mathcal{N}=\left(1,0\right) \) theories in terms of anomaly inflow. Our computation sheds some light on the reason why the simplest 6d \( \mathcal{N}=\left(1,0\right) \) theory has E 8 flavor symmetry, and also partially explains a curious numerology in F-theory.

6d \( \mathcal{N}=\left(1,\;0\right) \) theories on S 1 /T 2 and class S theories: part II

We study the T 2 compactification of a class of 6d \( \mathcal{N}=\left(1,\;0\right) \) theories that is Higgsable to \( \mathcal{N}=\left(2,\;0\right) \) theories. We show that the resulting 4d \( \mathcal{N}=2 \) theory at the origin of the Coulomb branch and the parameter space is generically given by two superconformal matter sectors coupled by an infrared-free gauge...

6d \( \mathcal{N}=\left(1,0\right) \) theories on T 2 and class S theories. Part I

We show that the \( \mathcal{N}=\left(1,0\right) \) superconformal theory on a single M5 brane on the ALE space of type G = A n , D n , E n , when compactified on T 2, becomes a class S theory of type G on a sphere with two full punctures and a simple puncture. We study this relation from various viewpoints. Along the way, we develop a new method to study the 4d SCFT arising from...

Anomaly polynomial of E-string theories

We determine the anomaly polynomial of the E-string theory and its higher-rank generalizations, that is, the 6d \( \mathcal{N} \) = (1, 0) superconformal theories on the worldvolume of one or multiple M5-branes embedded within the end-of-the-world brane with E 8 symmetry.

Anomaly polynomial of general 6D SCFTs

We describe a method to determine the anomaly polynomials of general 6D $\mathcal {N}={(2,0)}$ and $\mathcal {N}={(1,0)}$ superconformal field theories (SCFTs), in terms of the anomaly matching on their tensor branches. This method is almost purely field theoretical, and can be applied to all known 6D SCFTs. We demonstrate our method in many concrete examples, including $\mathcal...

Neuropathogenicity of Two Saffold Virus Type 3 Isolates in Mouse Models

Objective Saffold virus (SAFV), a picornavirus, is occasionally detected in children with acute flaccid paralysis, meningitis, and cerebellitis; however, the neuropathogenicity of SAFV remains undetermined. Methods The virulence of two clinical isolates of SAFV type 3 (SAFV-3) obtained from a patient with aseptic meningitis (AM strain) and acute upper respiratory inflammation (UR...

The Role of VP1 Amino Acid Residue 145 of Enterovirus 71 in Viral Fitness and Pathogenesis in a Cynomolgus Monkey Model

Enterovirus 71 (EV71), a major causative agent of hand, foot, and mouth disease, occasionally causes severe neurological symptoms. We identified P-selectin glycoprotein ligand-1 (PSGL-1) as an EV71 receptor and found that an amino acid residue 145 in the capsid protein VP1 (VP1-145) defined PSGL-1-binding (PB) and PSGL-1-nonbinding (non-PB) phenotypes of EV71. However, the role...

Enterovirus 71 Binding to PSGL-1 on Leukocytes: VP1-145 Acts as a Molecular Switch to Control Receptor Interaction

Jeffrey M. Bergelson 0 Hiroyuki Shimizu 0 Carolyn B. Coyne, University of Pittsburgh, United States of America 0 1 Department of Virology II, National Institute of Infectious Diseases , Musashimurayama-shi

Tyrosine Sulfation of the Amino Terminus of PSGL-1 Is Critical for Enterovirus 71 Infection

Enterovirus 71 (EV71) is one of the major causative agents of hand, foot, and mouth disease, a common febrile disease in children; however, EV71 has been also associated with various neurological diseases including fatal cases in large EV71 outbreaks particularly in the Asia Pacific region. Recently we identified human P-selectin glycoprotein ligand-1 (PSGL-1) as a cellular...

Nesfatin-1 Induces the Phosphorylation Levels of cAMP Response Element-Binding Protein for Intracellular Signaling in a Neural Cell Line

Nesfatin-1 is a novel anorexic peptide that reduces the food intake of rodents when administered either intraventricularly or intraperitoneally. However, the molecular mechanism of intracellular signaling via Nesfatin-1 is yet to be resolved. In the current study, we investigated the ability of different neuronal cell lines to respond to Nesfatin-1 and further elucidated the...

Characteristics of an Environmentally Monitored Prolonged Type 2 Vaccine Derived Poliovirus Shedding Episode that Stopped without Intervention

Vaccine derived poliovirus (VDPV) type 2 strains strongly divergent from the corresponding vaccine strain, Sabin 2, were repeatedly isolated from sewage in Slovakia over a period of 22 months in 2003–2005. Cell cultures of stool specimens from known immune deficient patients and from an identified putative source population of 500 people failed to identify the potential excretor...

Vagal Hyperactivity Due to Ventromedial Hypothalamic Lesions Increases Adiponectin Production and Release

In obese humans and animals, adiponectin production and release in adipose tissue are downregulated by feedback inhibition, resulting in decreased serum adiponectin. We investigated adiponectin production and release in ventromedial hypothalamic (VMH)-lesioned animals. VMH-lesioned mice showed significant increases in food intake and body weight gain, with hyperinsulinemia and...

The preparation of an infectious full-length cDNA clone of Saffold virus

The pathogenicity of Saffold virus (SAFV) among humans still remains unclear, although it was identified as a novel human cardiovirus in 2007. In order to encourage the molecular pathogenetic studies of SAFV, we generated an infectious cDNA clone of SAFV type 3 (SAFV-3). The present study demonstrated that the synthesis of the full-length infectious RNA by T7 RNA polymerase was...

Prostaglandin E2 regulates the expression of connective tissue growth factor (CTGF/CCN2) in human osteoarthritic chondrocytes via the EP4 receptor

Background The regulatory mechanisms of the expression of connective tissue growth factor/CCN family member 2 (CTGF/CCN2) in human articular chondrocytes have not been clarified. We investigated the effect of prostaglandin E2 (PGE2) on CTGF/CCN2 expression in chondrocytes. Findings Articular cartilage samples were obtained from patients with osteoarthritis (OA) and chondrocytes...

Neonatal Lethality in Knockout Mice Expressing the Kinase-Dead Form of the Gefitinib Target GAK Is Caused by Pulmonary Dysfunction

Gefitinib (Iressa) is an inhibitor of the epidermal growth factor receptor (EGFR) that has shown promising activity in the treatment of patients with non-small cell lung cancer (NSCLC). However, adverse side effects of gefitinib treatment, such as respiratory dysfunction, have limited the therapeutic benefit of this targeting strategy. The present results show that this adverse...

Development of a reverse transcription-loop-mediated isothermal amplification (RT-LAMP) system for a highly sensitive detection of enterovirus in the stool samples of acute flaccid paralysis cases

Background In the global eradication program for poliomyelitis, the laboratory diagnosis plays a critical role by isolating poliovirus (PV) from the stool samples of acute flaccid paralysis (AFP) cases. In this study, we developed a reverse transcription-loop-mediated isothermal amplification (RT-LAMP) system for a rapid and highly sensitive detection of enterovirus including PV...