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Search: authors:"Hitoshi Kawano"

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Post-Marketing Surveillance of Fluvoxamine Maleate Used Long-Term in Patients with Social Anxiety Disorder in Japan

Background No data on the long-term ‘real-world’ use of fluvoxamine for the treatment of social anxiety disorder (SAD) in Japanese patients are currently available. Objective To evaluate the long-term safety and efficacy of fluvoxamine for SAD in the clinical setting. Methods Japanese patients with SAD who initiated treatment with fluvoxamine were enrolled in this 53-week ...

Nicotine-Like Effects of the Neonicotinoid Insecticides Acetamiprid and Imidacloprid on Cerebellar Neurons from Neonatal Rats

Hitoshi Kawano 0 Shu-ichi Okamoto, Sanford-Burnham Medical Research Institute, United States of America 0 Department of Brain Development and Neural Regeneration, Tokyo Metropolitan Institute of Medical

Role of the lesion scar in the response to damage and repair of the central nervous system

Traumatic damage to the central nervous system (CNS) destroys the blood–brain barrier (BBB) and provokes the invasion of hematogenous cells into the neural tissue. Invading leukocytes, macrophages and lymphocytes secrete various cytokines that induce an inflammatory reaction in the injured CNS and result in local neural degeneration, formation of a cystic cavity and activation of ...

PQBP-1 transgenic mice show a late-onset motor neuron disease-like phenotype

A body of experimental evidence indicates that transcription and/or mRNA processing factors interacting with the polyglutamine disease gene products play crucial roles in the pathology. PQBP-1 is one of these factors and it has been shown to interact with the spinocerebellar ataxia type-1 (SCA1) disease gene product, ataxin-1. Our previous data suggested that relatively high ...