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Identification and characterization of two linear epitope motifs in hepatitis E virus ORF2 protein

Contributions Conceptualization: Heng Wang, Guihong Zhang. Formal analysis: Meng Zeng, Ruyue Song. Investigation: Weidong Zhang, Honglang Gu, Wanli Chen. Project administration: Heng Wang, Guihong Zhang ... . Resources: Meng Zeng, Chihai Ji. Supervision: Guihong Zhang. Validation: Weidong Zhang, Honglang Gu, Wanli Chen. Writing ± original draft: Heng Wang. Writing ± review & editing: Guihong Zhang. 13 / 15 14

A Proline-Rich Domain in the Genotype 4 Hepatitis E Virus ORF3 C-Terminus Is Crucial for Downstream V105DLP108 Immunoactivity

The hepatitis E virus (HEV) is responsible for serious viral hepatitis worldwide. Animals are considered a reservoir of HEV, particularly pigs. While HEV infection in pigs and dogs is always asymptomatic, the virus causes high death rates in patients with pre-existing chronic liver disease and pregnant women in developing countries. HEV open reading frame 2 (ORF2) has been used...

The Prevalence of Hepatitis E Virus Infections among Swine, Swine Farmers and the General Population in Guangdong Province, China

Hepatitis E virus (HEV) infection is widespread in China, but few studies have been carried out in Guangdong Province. This study aimed to characterize the prevalence of HEV infections among swine, swine farmers and the general population in Guangdong Province. We conducted an epidemiological study that included swine, swine farmers and health examination attendees in Guangdong...