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Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells

secretarial supports. Author Contributions Data curation: Yasunobu Miyake. 14 / 16 Investigation: Honglian Tong, Yoichiro Iwakura, Hiromitsu Hara. Methodology: Fumika Mi-ichi. Project administration: Hiroki ... Yoshida. Resources: Hiroki Yoshida. Supervision: Yasunobu Miyake, Fumika Mi-ichi, Hiroki Yoshida. Writing ± original draft: Honglian Tong. 15 / 16 2012; 265(1):103±12.

Forkhead Box Protein O3 Transcription Factor Negatively Regulates Autophagy in Human Cancer Cells by Inhibiting Forkhead Box Protein O1 Expression and Cytosolic Accumulation

FoxO proteins are important regulators in cellular metabolism and are recognized to be nodes in multiple signaling pathways, most notably those involving PI3K/AKT and mTOR. FoxO proteins primarily function as transcription factors, but recent study suggests that cytosolic FoxO1 participates in the regulation of autophagy. In the current study, we find that cytosolic FoxO1 indeed...