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Identification of microRNA biomarkers in type 2 diabetes: a meta-analysis of controlled profiling studies

Aims/hypothesis The aim was to identify potential microRNA (miRNA) biomarkers of type 2 diabetes. Methods Controlled studies were retrieved from PubMed to compare miRNA expression profiles of type 2 diabetes and nondiabetic control samples. Meta-analysis under a random effects model was conducted. Subgroup analyses examined tissue specificity and species specificity. Sensitivity...

Targeting Human α-Lactalbumin Gene Insertion into the Goat β-Lactoglobulin Locus by TALEN-Mediated Homologous Recombination

Special value of goat milk in human nutrition and well being is associated with medical problems of food allergies which are caused by milk proteins such as β-lactoglobulin (BLG). Here, we employed transcription activator-like effector nuclease (TALEN)-assisted homologous recombination in goat fibroblasts to introduce human α-lactalbumin (hLA) genes into goat BLG locus. TALEN...

Non-Invasive Prenatal Diagnosis of Lethal Skeletal Dysplasia by Targeted Capture Sequencing of Maternal Plasma

Background Since the discovery of cell-free foetal DNA in the plasma of pregnant women, many non-invasive prenatal testing assays have been developed. In the area of skeletal dysplasia diagnosis, some PCR-based non-invasive prenatal testing assays have been developed to facilitate the ultrasound diagnosis of skeletal dysplasias that are caused by de novo mutations. However...

Accumulation of invariant NKT cells with increased IFN-γ production in persistent high-risk HPV-infected high-grade cervical intraepithelial neoplasia

Background Persistent high-risk human papillomavirus (HR-HPV) infection has been implicated in the development of high-grade cervical intraepithelial neoplasia (CIN) and cervical cancer. Invariant natural killer T (iNKT) cells produce large amounts of cytokines to regulate immune responses. However, the role of iNKT cells in human persistent HPV-infected cervical tissues is...

Effect of Aripiprazole on Mismatch Negativity (MMN) in Schizophrenia

Background Cognitive deficits are considered core symptoms of the schizophrenia. Cognitive function has been found to be a better predictor of functional outcome than symptom levels. Changed mismatch negativity (MMN) reflects abnormalities of early auditory processing in schizophrenia. Up to now, no studies for the effects of aripiprazole on MMN in schizophrenia have been...

Targeted genomic capture and massively parallel sequencing to identify novel variants causing Chinese hereditary hearing loss

Background Hereditary hearing loss is genetically heterogeneous, and hundreds of mutations in than 60 genes are involved in this disease. Therefore, it is difficult to identify the causative gene mutations involved. In this study, we combined targeted genomic capture and massively parallel sequencing (MPS) to address this issue. Methods Using targeted genomic capture and MPS, 104...

Comparative efficacy of glimepiride and metformin in monotherapy of type 2 diabetes mellitus: meta-analysis of randomized controlled trials

Background Metformin treatment has been the most recommended monotherapy of type 2 diabetes mellitus (T2DM) for decades but is challenged by new antidiabetic drugs. This study conducted a meta-analysis of randomized controlled trials (RCT) comparing the efficacy of metformin and glimepiride in monotherapy of T2DM. Methods A literature search for RCTs on glimepiride and metformin...

Estimation of Time-Varying Coherence and Its Application in Understanding Brain Functional Connectivity

William Gaetz 0 Hongmei Zhu (EURASIP Member) 1 L. F. Chaparro 0 Biomagnetic Imaging Laboratory, Children's Hospital of Philadelphia , Philadelphia, PA 19104 , USA 1 Department of Mathematics and Statistics

Heterogeneous nucleation of β-type precipitates on nanoscale Zr-rich particles in a Mg-6Zn-0.5Cu-0.6Zr alloy

Zirconium (Zr) is an important alloying element to Mg-Zn-based alloy system. In this paper, we report the formation of the β-type precipitates on the nanoscale Zr-rich particles in a Mg-6Zn-0.5Cu-0.6Zr alloy during ageing at 180°C. Scanning transmission electron microscopy examinations revealed that the nanoscale Zr-rich [0001]α rods/laths are dominant in the Zr-rich core regions...

Flame synthesis of carbon nanostructures on Ni-plated hardmetal substrates

In this article, we demonstrate that carbon nanostructures could be synthesized on the Ni-plated YG6 (WC-6 wt% Co) hardmetal substrate by a simple ethanol diffusion flame method. The morphologies and microstructures of the Ni-plated layer and the carbon nanostructures were examined by various techniques including scanning electron microscopy, X-ray diffraction, and Raman...