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Horseradish Peroxidase-Encapsulated Hollow Silica Nanospheres for Intracellular Sensing of Reactive Oxygen Species

Reactive oxygen species (ROS) have crucial roles in cell signaling and homeostasis. Overproduction of ROS can induce oxidative damage to various biomolecules and cellular structures. Therefore, developing an approach capable of monitoring and quantifying ROS in living cells is significant for physiology and clinical diagnoses. Some cell-permeable fluorogenic probes developed are...

Association of Neovascular Glaucoma with Risk of Stroke: A Population-Based Cohort Study

Neovascular glaucoma (NVG), caused by ocular ischemia, is a serious ocular disease complicated by intractably increased intraocular pressure. Cerebrovascular accidents are classified into ischemic and hemorrhagic stroke. Based on the similar pathogenic mechanisms of NVG and ischemic stroke, we investigated the relationship between NVG and stroke by using a nationally...

Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles

. TangInstitute of Biochemistry and Molecular Biology, College of Life Sciences, National Yang-Ming University, Taipei, TaiwanWon-Jing Wang AuthorsSearch for Hsin-Yi Chen in:Nature Research journals • PubMed

Potential Protein Phosphatase 2A Agents from Traditional Chinese Medicine against Cancer

process with the PP2A-α protein. Conflict of Interests The authors declared that there is no conflict of interests. Authors’ Contribution Kuan-Chung Chen and Hsin-Yi Chen had equal contribution

Potential Protein Phosphatase 2A Agents from Traditional Chinese Medicine against Cancer

process with the PP2A-α protein. Conflict of Interests The authors declared that there is no conflict of interests. Authors’ Contribution Kuan-Chung Chen and Hsin-Yi Chen had equal contribution

Finding Inhibitors of Mutant Superoxide Dismutase-1 for Amyotrophic Lateral Sclerosis Therapy from Traditional Chinese Medicine

therapy. Conflict of Interests The authors reaffirm that they have no conflict of interests to declare. Authors’ Contribution Hung-Jin Huang, Tung-Ti Chang, and Hsin-Yi Chen contributed equally to this

Resveratrol Modulates Mitochondria Dynamics in Replicative Senescent Yeast Cells

Mitochondria form a reticulum network dynamically fuse and divide in the cell. The balance between mitochondria fusion and fission is correlated to the shape, activity and integrity of these pivotal organelles. Resveratrol is a polyphenol antioxidant that can extend life span in yeast and worm. This study examined mitochondria dynamics in replicative senescent yeast cells as well...

Fetal and Childhood Exposure to Phthalate Diesters and Cognitive Function in Children Up to 12 Years of Age: Taiwanese Maternal and Infant Cohort Study

: HBH. Contributed reagents/ materials/analysis tools: HBH PHS Hsin-Yi Chen PCH CWS CJW Hsiao-Yen Chen SLW. Wrote the paper: HBH. Critical revision of the manuscript: PCH CAH SLW. 18. Koch HM, Gonzalez

Identification of Potent EGFR Inhibitors from TCM Database@Taiwan

Overexpression of epidermal growth factor receptor (EGFR) has been associated with cancer. Targeted inhibition of the EGFR pathway has been shown to limit proliferation of cancerous cells. Hence, we employed Traditional Chinese Medicine Database (TCM Database@Taiwan) (http://tcm.cmu.edu.tw) to identify potential EGFR inhibitor. Multiple Linear Regression (MLR), Support Vector...

Retinitis Pigmentosa Reduces the Risk of Proliferative Diabetic Retinopathy: A Nationwide Population-Based Cohort Study

Purpose To study the association between retinitis pigmentosa (RP) and the progression of diabetic retinopathy (DR). Methods Using the Longitudinal Health Insurance Database 2000 of Taiwan, we identified individuals with an initial diagnosis for RP during the period of 1997–2008. A non-RP comparison group, 10-fold frequency matched by sex, age, index year and the year of diabetes...

Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition

mTOR inhibitors are used clinically to treat renal cancer but are not curative. Here we show that autophagy is a resistance mechanism of human renal cell carcinoma (RCC) cell lines to mTOR inhibitors. RCC cell lines have high basal autophagy that is required for survival to mTOR inhibition. In RCC4 cells, inhibition of mTOR with CCI-779 stimulates autophagy and eliminates RIP...

Compounds from Wedelia chinensis synergistically suppress androgen activity and growth in prostate cancer cells

Chronic inflammation can augment tumor development in various types of cancers, including prostate cancer (PCa). Reduction of inflammation is therefore an important anticancer therapeutic opportunity. Here, we report four anti-proliferative phytocompounds in Wedelia chinensis, an oriental herbal medicine, identified through their ability to modulate the androgen receptor (AR...