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Serum calcium, alkaline phosphotase and hemoglobin as risk factors for bone metastases in bladder cancer

Conceptualization: Jia-Ming Liu, Shan-Hu Huang. Data curation: Qing-Fu Yu, Wen-Zhao Chen. Formal analysis: Ping Huang, Min Lan. Methodology: Jia-Ming Liu, Shan-Hu Huang. Writing ± original draft: Ping Huang, Min

Pricing Decision in a Two-Echelon Supply Chain with Competing Retailers Under Uncertain Environment

This paper explores a supply chain pricing competition problem in a two-echelon supply chain with one manufacturer and two competing retailers. The manufacturing costs, sales costs, and market bases are all characterized as uncertain variables whose distributions are estimated by experts’ experienced data. In consideration of channel members’ different market powers, three ...

Age-related macular degeneration phenotypes are associated with increased tumor necrosis-alpha and subretinal immune cells in aged Cxcr5 knockout mice

The role of chemokine receptor in age-related macular degeneration (AMD) remains elusive. The objective of this study is to investigate the role of chemokine receptor Cxcr5 in the pathogenesis of AMD. Cxcr5 gene expression levels (mRNA and protein) are higher in the retina and retinal pigment epithelium (RPE) of aged C57BL/6 wild type mice than younger ones. Vascular and glial ...

Equilibrium Analysis of Channel Structure Strategies in Uncertain Environment

In this paper, we consider a pricing decision problem with two competing supply chains which distribute differentiated but competing products in the same market. Each chain can be vertically integrated or decentralized based on the choice of the manufacturer. The manufacturing costs, sales costs and consumer demands are characterized as uncertain variables, whose distributions are ...

Uncertain pricing decision problem in closed-loop supply chain with risk-averse retailer

This paper considers a pricing and remanufacturing problem in closed-loop supply chain which includes one dominant manufacturer and one retailer under uncertain environment. The remanufacturing cost, market demand, and collection cost are characterized as uncertain variables. The firms’ optimal strategies are obtained by uncertainty-theory-based and game-theory-based models. ...

Chance-Constrained Model for RCPSP with Uncertain Durations

Project scheduling with uncertain durations becomes a research focus with the development of uncertainty theory. Most researches concerned aim at minimizing project makespan or project cost according to different decision criterions. However, few works considered resource constraint, which initially appeared in deterministic resource-constrained project scheduling problem (RCPSP) ...

Deletion of Placental Growth Factor Prevents Diabetic Retinopathy and Is Associated With Akt Activation and HIF1α-VEGF Pathway Inhibition

A new diabetic mouse strain, the Akita.PlGF knockout (−/−), was generated to study the role of placental growth factor (PlGF) in the pathogenesis of diabetic retinopathy (DR). PlGF deletion did not affect blood glucose but reduced the body weight of Akita.PlGF−/− mice. Diabetes-induced retinal cell death, capillary degeneration, pericyte loss, and blood-retinal barrier breakdown ...

Blockade of VEGFR1 and 2 Suppresses Pathological Angiogenesis and Vascular Leakage in the Eye

Objective VEGFR1 and 2 signaling have both been increasingly shown to mediate complications of ischemic retinopathies, including retinopathy of prematurity (ROP), age-related macular degeneration (AMD), and diabetic retinopathy (DR). This study evaluates the effects of blocking VEGFR1 and 2 on pathological angiogenesis and vascular leakage in ischemic retinopathy in a model of ROP ...

VEGF Receptor Blockade Markedly Reduces Retinal Microglia/Macrophage Infiltration into Laser-Induced CNV

Although blocking VEGF has a positive effect in wet age-related macular degeneration (AMD), the effect of blocking its receptors remains unclear. This was an investigation of the effect of VEGF receptor (VEGFR) 1 and/or 2 blockade on retinal microglia/macrophage infiltration in laser-induced choroidal neovascularization (CNV), a model of wet AMD. CNV lesions were isolated by laser ...

The evolution of machining-induced surface of single-crystal FCC copper via nanoindentation

The physical properties of the machining-induced new surface depend on the performance of the initial defect surface and deformed layer in the subsurface of the bulk material. In this paper, three-dimensional molecular dynamics simulations of nanoindentation are preformed on the single-point diamond turning surface of single-crystal copper comparing with that of pristine ...

Complex host genetics influence the microbiome in inflammatory bowel disease

Huang 5 Andrea D Tyler 7 Suzanne van Sommeren 6 10 Floris Imhann 6 10 Joanne M Stempak 7 Hu Huang 9 Pajau Vangay 9 Gabriel A Al-Ghalith 9 Caitlin Russell 3 4 Jenny Sauk 4 Jo Knight 13 Mark J Daly 1 11 14

NRF2 plays a protective role in diabetic retinopathy in mice

Aims/hypothesis Although much is known about the pathophysiological processes contributing to diabetic retinopathy (DR), the role of protective pathways has received less attention. The transcription factor nuclear factor erythroid-2-related factor 2 (also known as NFE2L2 or NRF2) is an important regulator of oxidative stress and also has anti-inflammatory effects. The objective of ...

BMSCs reduce rat granulosa cell apoptosis induced by cisplatin and perimenopause

Jun-qi Guo 0 Xia Gao 0 Zhi-jie Lin 0 Wei-zhen Wu 0 Liang-hu Huang Hui-yue Dong Jin Chen Jun Lu Yun-fen Fu Jin Wang Yu-jie Ma Xiao-wen Chen Zhi-xian Wu Fu-qiang He Shun-liang Yang Lian-ming Liao Feng

An epidemiological investigation of leukemia incidence between 2003 and 2007 in Nanjing, China

interests The authors declare that they have no competing interests. Authors' contributions Bao-An Chen, Zhi-Hu Huang and Xiao-Ping Zhang collected the data and contributed to analysis and writing. Jian Ou