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Pricing Decision in a Two-Echelon Supply Chain with Competing Retailers Under Uncertain Environment

This paper explores a supply chain pricing competition problem in a two-echelon supply chain with one manufacturer and two competing retailers. The manufacturing costs, sales costs, and market bases are all characterized as uncertain variables whose distributions are estimated by experts’ experienced data. In consideration of channel members’ different market powers, three ...

Uncertain Resource-Constrained Project Scheduling Problem with Net Present Value Criterion

On the basis of uncertainty theory, plenty of researches have been done on uncertain resource-constrained project scheduling problems. Instead of minimizing the makespan, in this paper, we address the maximization of net present value of a project’s cash flows when activity durations are assumed to be uncertain. In addition to precedence constraint and resource constraint involved ...

Equilibrium Analysis of Channel Structure Strategies in Uncertain Environment

In this paper, we consider a pricing decision problem with two competing supply chains which distribute differentiated but competing products in the same market. Each chain can be vertically integrated or decentralized based on the choice of the manufacturer. The manufacturing costs, sales costs and consumer demands are characterized as uncertain variables, whose distributions are ...

A genetic algorithm-based optimizing approach for project time-cost trade-off with uncertain measure

Both the trade-off between the project cost and the project completion time and the indeterminacy of the environment are important issues for real-life project managers. In this paper, an uncertain time-cost trade-off problem, where activity cost functions are assumed to be linear and the objective function to be minimized is the project direct cost, is described based on ...

Uncertain random time-cost trade-off problem

Since for most projects, ‘new’ parts (with little or no historical data) and ‘old’ parts (with sufficient historical data) always coexist in the same project, uncertainty and randomness should be considered simultaneously in time-cost trade-off problem. In this paper, combined with uncertainty theory and dependent-chance programming, an uncertain random time-cost trade-off model is ...

Bounds for the Z-spectral radius of nonnegative tensors

In this paper, we have proposed some new upper bounds for the largest Z-eigenvalue of an irreducible weakly symmetric and nonnegative tensor, which improve the known upper bounds obtained in Chang et al. (Linear Algebra Appl 438:4166–4182, 2013), Song and Qi (SIAM J Matrix Anal Appl 34:1581–1595, 2013), He and Huang (Appl Math Lett 38:110–114, 2014), Li et al. (J Comput Anal Appl ...

Uncertain pricing decision problem in closed-loop supply chain with risk-averse retailer

This paper considers a pricing and remanufacturing problem in closed-loop supply chain which includes one dominant manufacturer and one retailer under uncertain environment. The remanufacturing cost, market demand, and collection cost are characterized as uncertain variables. The firms’ optimal strategies are obtained by uncertainty-theory-based and game-theory-based models. ...

Chance-Constrained Model for RCPSP with Uncertain Durations

Project scheduling with uncertain durations becomes a research focus with the development of uncertainty theory. Most researches concerned aim at minimizing project makespan or project cost according to different decision criterions. However, few works considered resource constraint, which initially appeared in deterministic resource-constrained project scheduling problem (RCPSP) ...

Berberine Protects against Neuronal Damage via Suppression of Glia-Mediated Inflammation in Traumatic Brain Injury

Traumatic brain injury (TBI) triggers a series of neuroinflammatory processes that contribute to evolution of neuronal injury. The present study investigated the neuroprotective effects and anti-inflammatory actions of berberine, an isoquinoline alkaloid, in both in vitro and in vivo TBI models. Mice subjected to controlled cortical impact injury were injected with berberine (10 ...

Post-Injury Treatment with 7,8-Dihydroxyflavone, a TrkB Receptor Agonist, Protects against Experimental Traumatic Brain Injury via PI3K/Akt Signaling

Tropomyosin-related kinase B (TrkB) signaling is critical for promoting neuronal survival following brain damage. The present study investigated the effects and underlying mechanisms of TrkB activation by the TrkB agonist 7,8-dihydroxyflavone (7,8-DHF) on traumatic brain injury (TBI). Mice subjected to controlled cortical impact received intraperitoneal 7,8-DHF or vehicle injection ...

High Prevalence of Vitamin D Insufficiency in China: Relationship with the Levels of Parathyroid Hormone and Markers of Bone Turnover

There is a lack of large-scale studies on vitamin D status and its relationship to parathyroid hormone (PTH) and bone turnover markers in adults living in Shanghai. The objectives were to determine the prevalence of vitamin D insufficiency in Shanghai and to investigate the relationship of 25(OH)D with parathyroid function and bone turnover markers. This cross-sectional study ...

Association between Low Density Lipoprotein Receptor-Related Protein 2 Gene Polymorphisms and Bone Mineral Density Variation in Chinese Population

Low density lipoprotein receptor-related protein 2 gene (LRP2) is located next to the genomic region showing suggestive linkage with both hip and wrist bone mineral density (BMD) phenotypes. LRP2 knockout mice showed severe vitamin D deficiency and bone disease, indicating the involvement of LRP2 in the preservation of vitamin D metabolites and delivery of the precursor to the ...

Rapid and efficient site-directed mutagenesis by single-tube ‘megaprimer’ PCR method

We describe a rapid and efficient megaprimer PCR procedure for site-directed mutagenesis that does not require any intermediate purification of DNA between the two rounds of PCR. This protocol is based on the design of forward and reverse flanking primers with significantly different melting temperatures (Tm). A megaprimer is synthesized in the first PCR reaction using a mutagenic ...

The Thermal Stability of DNA Fragments With Tandem Mismatches at a d(CXYG)d(CY′X′G) Site

Song-Hua Ke 0 Roger M. Wartell 0 0 School of Biology, Georgia Institute of Technology , Atlanta, GA 30332, USA Temperature-Gradient Gel Electrophoresis (TGGE) was employed to determine the thermal