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Carbidopa, a drug in use for management of Parkinson disease inhibits T cell activation and autoimmunity

National Institutes of Health grant R01DK103576 to NS. Author Contributions Conceptualization: Nagendra Singh. Data curation: Huabin Zhu, Henrique Lemos, Brinda Bhatt, Bianca N. Islam, Ashish Gurav, Lei

Effect of Vitrification on the MicroRNA Transcriptome in Mouse Blastocysts

Vitrification is commonly used in the cryopreservation of mammalian blastocysts to overcome the temporal and spatial limitations of embryo transfer. Previous studies have shown that the implantation ability of vitrified blastocysts is impaired and that microRNAs (miRNAs) regulate the critical genes for embryo implantation. However, little information is available about the effect...

Expression of Intracellular Interferon-Alpha Confers Antiviral Properties in Transfected Bovine Fetal Fibroblasts and Does Not Affect the Full Development of SCNT Embryos

Foot-and-mouth disease, one of the most significant diseases of dairy herds, has substantial effects on farm economics, and currently, disease control measures are limited. In this study, we constructed a vector with a human interferon-α (hIFN-α) (without secretory signal sequence) gene cassette containing the immediate early promoter of human cytomegalovirus. Stably transfected...