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Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer’s disease

Amyloid-beta (Aβ) plays a pivotal role in the pathogenesis of Alzheimer’s disease (AD). The physiological capacity of peripheral tissues and organs in clearing brain-derived Aβ and its therapeutic potential for AD remains largely unknown. Here, we measured blood Aβ levels in different locations of the circulation in humans and mice, and used a parabiosis model to investigate the...

Two ultraviolet radiation datasets that cover China

Ultraviolet (UV) radiation has significant effects on ecosystems, environments, and human health, as well as atmospheric processes and climate change. Two ultraviolet radiation datasets are described in this paper. One contains hourly observations of UV radiation measured at 40 Chinese Ecosystem Research Network stations from 2005 to 2015. CUV3 broadband radiometers were used to...

Spatiotemporal Variation and Abrupt Change Analysis of Temperature from 1960 to 2012 in the Huang-Huai-Hai Plain, China

Based on a monthly dataset of temperature time series (1960–2012) in the Huang-Huai-Hai Plain of China (HHHPC), spatiotemporal variation and abrupt change analysis of temperature were examined by moving average, linear regression, spline interpolation, Mann-Kendall test, and moving t-test. Major conclusions were listed as follows. (1) Annual and seasonal temperature increased...

Autophagy induction contributes to the resistance to methotrexate treatment in rheumatoid arthritis fibroblast-like synovial cells through high mobility group box chromosomal protein 1

Background Rheumatoid arthritis fibroblast-like synovial cells (RA-FLS) show resistance to methotrexate (MTX) treatment. To better understand the mechanisms of this resistance, RA-FLS and osteoarthritis fibroblast-like synovial cells (OA-FLS) were isolated and exposed to MTX. We analyzed the autophagy induced by MTX in vitro and its relationship to apoptosis. Methods Cell...

Protein function prediction by collective classification with explicit and implicit edges in protein-protein interaction networks

analysis, and drafted the manuscript. Hui Liu prepared the datasets. Acknowledgements Based on Effectively predicting protein functions by collective classification An extended abstract, by Wei Xiong, Hui ... Program (grant No. 2012AA020403) and 973 program (grant No. 2010CB126604). Hui Liu was supported by NSFC (grant No. 31100954). Jihong Guan was supported by NSFC (grant No. 61173118), Shuigeng Zhou was also

Prediction of novel long non-coding RNAs based on RNA-Seq data of mouse Klf1 knockout study

Hui Liu 0 0 School of Information and Electrical Engineering, China University of Mining and Technology , Xuzhou, JiangSu 221008 , PR China Background: Study on long non-coding RNAs (lncRNAs) has been

Improving performance of mammalian microRNA target prediction

results are available at http://compgenomics. utsa.edu/svmicro.html. Additional material Additional file 1: Supplementary Information. Acknowledgements Hui Liu is supported by the talent introduction

GeneLibrarian: an effective gene-information summarization and visualization system

Background Abundant information about gene products is stored in online searchable databases such as annotation or literature. To efficiently obtain and digest such information, there is a pressing need for automated information-summarization and functional-similarity clustering of genes. Results We have developed a novel method for semantic measurement of annotation and...

Suppression of histone deacetylation promotes the differentiation of human pluripotent stem cells towards neural progenitor cells

Background Emerging studies of human pluripotent stem cells (hPSCs) raise new prospects for neurodegenerative disease modeling and cell replacement therapies. Therefore, understanding the mechanisms underlying the commitment of neural progenitor cells (NPCs) is important for the application of hPSCs in neurodegenerative disease therapies. It has been reported that epigenetic...

A novel MVA-mediated pathway for isoprene production in engineered E. coli

Background To deal with the increasingly severe energy crisis and environmental consequences, biofuels and biochemicals generated from renewable resources could serve as a promising alternative for replacing petroleum as a source of fuel and chemicals, among which isoprene (2-methyl-1,3-butadiene) in particular is of great significance in that it is an important platform chemical...

Thermochemotherapy effect of nanosized As2O3/Fe3O4 complex on experimental mouse tumors and its influence on the expression of CD44v6, VEGF-C and MMP-9

Background Both thermotherapy and arsenic have been shown to be active against a broad spectrum of cancers. To reduce the limitations of conventional thermotherapy, improve therapeutic anticancer activity, reduce the toxicity of arsenic on normal tissue, and increase tissue-specific delivery, we prepared a nanosized As2O3/Fe3O4 complex (Fe3O4 magnetic nanoparticles encapsulated...

Tanshinone IIA combined with adriamycin inhibited malignant biological behaviors of NSCLC A549 cell line in a synergistic way

Background The study was designed to develop a platform to verify whether the extract of herbs combined with chemotherapy drugs play a synergistic role in anti-tumor effects, and to provide experimental evidence and theoretical reference for finding new effective sensitizers. Methods Inhibition of tanshinone IIA and adriamycin on the proliferation of A549, PC9 and HLF cells were...

3D-image-guided HDR-brachytherapy versus 2D HDR - brachytherapy after external beam radiotherapy for early T-stage nasopharyngeal carcinoma

Background Two-dimensional high-dose-rate brachytherapy (2D-HDR-BT) is an effective method of dose escalation for local tumor control in early T-stage nasopharyngeal carcinoma (NPC). Treatment outcomes for 3D-image-guided high-dose-rate brachytherapy (3D-image-guided-HDR-BT) after external beam radiotherapy (ERT) have not been examined in early T-stage NPC patients. The current...

Tumor suppressor BLU inhibits proliferation of nasopharyngeal carcinoma cells by regulation of cell cycle, c-Jun N-terminal kinase and the cyclin D1 promoter

Background Tumor suppressor genes function to regulate and block tumor cell proliferation. To explore the mechanisms underlying the tumor suppression of BLU/ZMYND10 gene on a frequently lost human chromosomal region, an adenoviral vector with BLU cDNA insert was constructed. Methods BLU was re-expressed in nasopharyngeal carcinoma cells by transfection or viral infection...

The role of MMP-1 in breast cancer growth and metastasis to the brain in a xenograft model

Background Brain metastasis is an increasingly common complication for breast cancer patients; approximately 15– 30% of breast cancer patients develop brain metastasis. However, relatively little is known about how these metastases form, and what phenotypes are characteristic of cells with brain metastasizing potential. In this study, we show that the targeted knockdown of MMP-1...

In vitro anti-angiogenic properties of LGD1069, a selective retinoid X-receptor agonist through down-regulating Runx2 expression on Human endothelial cells

Background LGD1069 (Targretin®) is a selective retinoid X receptor (RXR) ligand, which is used in patients for cutaneous T-cell lymphoma. Our published study reported that LGD1069 inhibited tumor-induced angiogenesis in non-small cell lung cancer. In present study, we found that LGD1069 suppressed the proliferation, adhesion, invasion and migration of endothelial cells directly...

The 100 most-cited articles on aortic dissection

Lai et al. BMC Cardiovascular Disorders Ping Lai Yuan-hui Liu 0 Jin-hua Xue Peng-cheng He 0 Yue-qun Qiu 1 0 Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key

N-terminal pro-brain natriuretic peptide improves the C-ACS risk score prediction of clinical outcomes in patients with ST-elevation myocardial infarction

Background It remained unclear whether the combination of the Canada Acute Coronary Syndrome Risk Score (CACS-RS) and N-terminal pro-brain natriuretic peptide (NT-pro-BNP) could have a better performance in predicting clinical outcomes in acute ST-elevation myocardial infarction (STEMI) patients with primary percutaneous coronary intervention. Methods A total of 589 consecutive...

Role of SIRT3 in Angiotensin II-induced human umbilical vein endothelial cells dysfunction

Background SIRT3, a member of the sirtuin family of NAD + -dependent deacetylases, resides primarily in the mitochondria and has been shown to deacetylate several metabolic and respiratory enzymes that regulate important mitochondrial functions. Previous researches show an important role of SIRT3 in regulating the production of reactive oxygen species (ROS), and highlight the...

The 100 most-cited articles on cardiovascular diseases from Mainland China

Background China, as a rapidly developing country with the largest population of cardiologist in the world, has an increasing importance in the field of cardiology. However, the quantity and quality of research production in the field of cardiology is unclear. Aims To analyze the characteristics of the high-level articles published on cardiovascular diseases in Mainland China...