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10-W pulsed operation of substrate emitting photonic-crystal quantum cascade laser with very small divergence

High-power broad area substrate emitting photonic-crystal distributed feedback (DFB) quantum cascade lasers (QCLs) emitting around 4.73 μm is reported. Two-dimensional centered rectangular photonic-crystal (CRPC) grating is introduced to enhance optical coherence in large area device. Main lobe far-field radiation pattern with a very small divergence angle of about 0.65° × 0.31...

3D-image-guided HDR-brachytherapy versus 2D HDR - brachytherapy after external beam radiotherapy for early T-stage nasopharyngeal carcinoma

Background Two-dimensional high-dose-rate brachytherapy (2D-HDR-BT) is an effective method of dose escalation for local tumor control in early T-stage nasopharyngeal carcinoma (NPC). Treatment outcomes for 3D-image-guided high-dose-rate brachytherapy (3D-image-guided-HDR-BT) after external beam radiotherapy (ERT) have not been examined in early T-stage NPC patients. The current...

A Bayesian approach for identifying miRNA targets by combining sequence prediction and gene expression profiling

performance. Acknowledgements Hui Liu and Lin Zhang are supported by the talent introduction project of China University of Mining Technology, the set-sail project of China University of Mining Technology and

A Longitudinal Study of Posttraumatic Stress Disorder Symptoms and Its Relationship with Coping Skill and Locus of Control in Adolescents after an Earthquake in China

Background/Objectives Post-traumatic stress disorder is a common psychological maladaptation among adolescents after undergoing an earthquake. Knowledge about the prevalence and maintenance of post-traumatic stress disorder symptoms and the changes of its predictors over time can help medical providers assist adolescent survivors with mitigating long-term impacts. This study...

A Meta-Analysis of the Association between TNF-α −308G>A Polymorphism and Type 2 Diabetes Mellitus in Han Chinese Population

Objective A meta-analysis was applied to evaluate the associations between tumor necrosis factor-α (TNF-α) −308G>A (rs1800629) polymorphism and type 2 diabetes mellitus (T2DM). Methods Hardy-Weinberg equilibrium (HWE) was employed to test genetic equilibrium among the genotypes of the selected literature. Power analysis was performed with the Power and Sample Size Calculation (PS...

A Time line of the Environmental Genetics of the Haptophytes

The use of genomic data and the rise of phylogenomics have radically changed our view of the eukaryotic tree of life at a high taxonomic level by identifying 4–6 “supergroups.” Yet, our understanding of the evolution of key innovations within each of these supergroups is limited because of poor species sampling relative to the massive diversity encompassed by each supergroup...

A comparison of seasonal growth and development of the copepods Calanus marshallae and C. pacificus in the northern Gulf of Alaska

Alaska HUI LIU 0 RUSSELL R. HOPCROFT 0 0 INSTITUTE OF MARINE SCIENCE The juvenile growth rates and development times of subarctic Calanus marshallae and temperate/ sub-tropical C. pacificus were

A core microbiome associated with the peritoneal tumors of pseudomyxoma peritonei

Background Pseudomyxoma peritonei (PMP) is a malignancy characterized by dissemination of mucus-secreting cells throughout the peritoneum. This disease is associated with significant morbidity and mortality and despite effective treatment options for early-stage disease, patients with PMP often relapse. Thus, there is a need for additional treatment options to reduce relapse rate...

A facile hydrothermal approach to the synthesis of nanoscale rare earth hydroxides

Nanosized rare earth (RE) hydroxides including La(OH)3, Nd(OH)3, Pr(OH)3, Sm(OH)3, Gd(OH)3, and Er(OH)3 with rod-like morphology are fabricated via a convenient hydrothermal approach. This strategy calls for the first preparation of metal complexes between RE precursors and dodecylamine (DDA) in water/ethanol mixture at room temperature and subsequent thermal decomposition at...

A modified constitutive model for FRP confined concrete in circular sections and its implementation with OpenSees programming

OpenSees is a well-recognized open source platform with high compatibility, and it has a well-developed fiber element method to cope with nonlinear structural analysis. Fiber reinforced polymer (FRP) confined concrete can effectively improve the seismic performance of concrete structures. However, sophisticated constitutive models for FRP confined concrete are not available in...

A nonparametric Bayesian approach for clustering bisulfate-based DNA methylation profiles

Background DNA methylation occurs in the context of a CpG dinucleotide. It is an important epigenetic modification, which can be inherited through cell division. The two major types of methylation include hypomethylation and hypermethylation. Unique methylation patterns have been shown to exist in diseases including various types of cancer. DNA methylation analysis promises to...

A novel MVA-mediated pathway for isoprene production in engineered E. coli

Background To deal with the increasingly severe energy crisis and environmental consequences, biofuels and biochemicals generated from renewable resources could serve as a promising alternative for replacing petroleum as a source of fuel and chemicals, among which isoprene (2-methyl-1,3-butadiene) in particular is of great significance in that it is an important platform chemical...

Abieslactone Induces Cell Cycle Arrest and Apoptosis in Human Hepatocellular Carcinomas through the Mitochondrial Pathway and the Generation of Reactive Oxygen Species

Abieslactone is a triterpenoid lactone isolated from Abies plants. Previous studies have demonstrated that its derivative abiesenonic acid methyl ester possesses anti-tumor-promoting activity in vitro and in vivo. In the present study, cell viability assay demonstrated that abieslactone had selective cytotoxicity against human hepatoma cell lines. Immunostaining experiments...

An N-terminal antibody promotes the transformation of amyloid fibrils into oligomers and enhances the neurotoxicity of amyloid-beta: the dust-raising effect

Yu-Hui Liu 0 Xian-Le Bu 0 Chun-Rong Liang Ye-Ran Wang Tao Zhang Shu-Sheng Jiao Fan Zeng Xiu-Qing Yao Hua-Dong Zhou Juan Deng Yan-Jiang Wang 0 Equal contributors Department of Neurology and Centre for

An evaluation of genotyping by sequencing (GBS) to map the Breviaristatum-e (ari-e) locus in cultivated barley

Abstract We explored the use of genotyping by sequencing (GBS) on a recombinant inbred line population (GPMx) derived from a cross between the two-rowed barley cultivar ‘Golden Promise’ (ari-e.GP/Vrs1) and the six-rowed cultivar ‘Morex’ (Ari-e/vrs1) to map plant height. We identified three Quantitative Trait Loci (QTL), the first in a region encompassing the spike architecture...

Analysis of exergy efficiency of a super-critical compressed carbon dioxide energy-storage system based on the orthogonal method

(2017YFB0903601) and Fundamental Research Funds for the Central Universities of China (No.2017XS050). Author Contributions Methodology: Hui Liu. Project administration: Wenyi Liu. Software: Hui Liu

Analysis of piston-pin lubrication considering the effects of structure deformation and cavitation

Running conditions for piston pin boss bearing have become very severe due to the high combustion pressure and piston temperature increase over the past ten years. The aim of this paper was to analyze the friction and lubrication characteristic of piston pin boss bearings and a connecting rod small end bearing. This paper provided a comprehensive analysis of piston pin based on a...

AnimalTFDB: a comprehensive animal transcription factor database

Transcription factors (TFs) are proteins that bind to specific DNA sequences, thereby playing crucial roles in gene-expression regulation through controlling the transcription of genetic information from DNA to RNA. Transcription cofactors and chromatin remodeling factors are also essential in the gene transcriptional regulation. Identifying and annotating all the TFs are primary...