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Clinical impact of monocyte distribution width and neutrophil-to-lymphocyte ratio for distinguishing COVID-19 and influenza from other upper respiratory tract infections: A pilot study

Academic Editing. 7 / 10 Author Contributions Data curation: Hui-Wen Chang, Yuarn-Jang Lee. Formal analysis: Sheng-Feng Lin. Software: Sheng-Feng Lin. Writing – original draft: Hui-An Lin. Writing

Isotypes of autoantibodies against novel differential 4-hydroxy-2-nonenal-modified peptide adducts in serum is associated with rheumatoid arthritis in Taiwanese women

Hospital, Taipei Medical University, New Taipei City, 23561, Taiwan Chih-Chun Tai & Yi-Fang Lin Department of Medical Laboratory, Taipei Medical University Hospital, Taipei, 11031, Taiwan Hui-Wen Chang ... PhD Program in Medical Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, 11031, Taiwan Hui-Wen Chang & Ching-Yu Lin Department of Biotechnology and Animal

Expression of HIF-1α and VEGF in feline mammary gland carcinomas: association with pathological characteristics and clinical outcomes

Google Scholar Wen-Ta Li View author publications You can also search for this author in PubMed Google Scholar Hui-Wen Chang View author publications You can also search for this author in PubMed ... this article. Author information AffiliationsGraduate Institute of Molecular and Comparative Pathobiology, National Taiwan University, Taipei, TaiwanBo Chen, Susanne Je-Han Lin, Wen-Ta Li, Hui-Wen

Role of nuclear factor-kappa B in feline injection site sarcoma

Yeh2,3, Chian-Ren Jeng1,3, Victor Fei Pang1,3, Hue-Ying Chiou4 na1 & Hui-Wen Chang  ORCID: orcid.org/0000-0001-8877-18861,3 na1  BMC Veterinary Research volume 15, Article number: 365 (2019) Cite this ...  L7842). Author information Author notes Hue-Ying Chiou and Hui-Wen Chang contributed equally to this work. AffiliationsGraduate Institute of Molecular and Comparative Pathobiology, School of Veterinary

Development and comparison of enzyme-linked immunosorbent assays based on recombinant trimeric full-length and truncated spike proteins for detecting antibodies against porcine epidemic diarrhea virus

• Google Scholar Search for Pei-Shiue Tsai in:PubMed • Google Scholar Search for Hue-Ying Chiou in:PubMed • Google Scholar Search for Chian-Ren Jeng in:PubMed • Google Scholar Search for Hui-Wen Chang ... authors had read and approved this manuscript. Corresponding author Correspondence to Hui-Wen Chang. Ethics declarations Ethics approval and consent to participate The procedures involving animals were

Gene Variations in Cis-Acting Elements between the Taiwan and Prototype Strains of Porcine Epidemic Diarrhea Virus Alter Viral Gene Expression

-Nan Lin Hui-Wen Chang Chen-Yu Lo Ching-Houng Lin Hung-Yi Wu In 2013, the outbreak of porcine epidemic diarrhea (PED) in Taiwan caused serious economic losses. In this study, we examined whether the ... reactions, as described in Table S1. 2.4. Analysis of DI RNA and sgm DI RNA Synthesis Using RT-qPCR The PEDV TW strain (GenBank Accession No. KP276252) was obtained from Dr. Hui-Wen Chang (National Taiwan

Identification of Neutralizing Monoclonal Antibodies Targeting Novel Conformational Epitopes of the Porcine Epidemic Diarrhoea Virus Spike Protein

Since 2010, newly identified variants of porcine epidemic diarrhoea virus (PEDV) have caused high mortality in neonatal piglets which has devastated the swine industry. The spike (S) glycoprotein of PEDV contains multiple neutralizing epitopes and is a major target for PEDV neutralization and vaccine development. To understand the antigenicity of the new PEDV variant, we...

Identification, characterization and purification of porcine Quiescin Q6-Sulfydryl Oxidase 2 protein

Post-spermiogenesis membrane surface modifications rely on molecules present in the reproductive tracts. Two isoforms (isoform 1 and 2) from Quiescin Q6-Sulfydryl Oxidase protein family have been identified in the male reproductive tract of rodent species. However, unlike isoform 1, scarce information is available for isoform 2, likely due to its lower expression level and lack...

The role of HGF-MET pathway and CCDC66 cirRNA expression in EGFR resistance and epithelial-to-mesenchymal transition of lung adenocarcinoma cells

Epithelial-to-mesenchymal transition (EMT) has, in recent years, emerged as an important tumor cell behavior associated with high metastatic potential and drug resistance. Interestingly, protein SUMOylation and hepatocyte growth factor could respectively reduce the effect of small molecule inhibitors on tyrosine kinase activity of mutated epidermal growth factor receptor of lung...

The effect of infection order of porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus on dually infected swine alveolar macrophages

Background Concurrent infection with porcine circovirus type 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) is known as one of the major causes for porcine respiratory disease complex (PRDC). Dual infection with PCV2 and PRRSV is consistently to have more severe clinical presentations and pulmonary lesions than infection with PCV2 alone or PRRSV alone...

The effect of infection order of porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus on dually infected swine alveolar macrophages

Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei, 106, Taiwan, Republic of ChinaYi-Chieh Tsai, Hui-Wen Chang, Chian-Ren Jeng, Chun-Ming Lin, Cho-Hua Wan ... the final manuscript. Yi-Chieh Tsai, Hui-Wen Chang contributed equally to this work. Authors’ original submitted files for images Below are the links to the authors’ original submitted files for

Genetic variations of MUC17 are associated with endometriosis development and related infertility

Background Genetic alterations of mucin genes, such as MUC2 and MUC4, were previously identified to be associated with endometriosis and related infertility. Additionally, gene expression profiling has confirmed MUC17 to be overexpressed in mucinous ovarian carcinoma; however, its associated risk for endometriosis remains unclear. This study was focused on the potential impact of...

Production of Mucosally Transmissible SHIV Challenge Stocks from HIV-1 Circulating Recombinant Form 01_AE env Sequences

Simian-human immunodeficiency virus (SHIV) challenge stocks are critical for preclinical testing of vaccines, antibodies, and other interventions aimed to prevent HIV-1. A major unmet need for the field has been the lack of a SHIV challenge stock expressing circulating recombinant form 01_AE (CRF01_AE) env sequences. We therefore sought to develop mucosally transmissible SHIV...

Phylodynamics and Molecular Evolution of Influenza A Virus Nucleoprotein Genes in Taiwan between 1979 and 2009

Background Many studies concentrate on variation in the hemagglutinin glycoprotein (HA) because of its significance in host immune response, the evolution of this virus is even more complex when other genome segments are considered. Recently, it was found that cytotoxic T lymphocytes (CTL) play an important role in immunity against influenza and most CTL epitopes of human...

MUC4 gene polymorphisms associate with endometriosis development and endometriosis-related infertility

Background Mucin 4 (MUC4) plays an important role in protecting and lubricating the epithelial surface of reproductive tracts, but its role in the pathogenesis of endometriosis is largely unknown. Methods To correlate MUC4 polymorphism with the risk of endometriosis and endometriosis-related infertility, we performed a case-control study of 140 patients and 150 healthy women. Six...

BMPR1B Up-Regulation via a miRNA Binding Site Variation Defines Endometriosis Susceptibility and CA125 Levels

Background Bone morphogenetic protein receptor I B (BMPR1B) is a transmembrane receptor mediating TGF-β signal transduction. Recent studies indicate a tumor suppressor role for BMPR1B in ovarian cancer. Polymorphism at BMPR1B 3′UTR within the miR-125b binding site alters its binding affinity toward the miRNA, which may result in insufficient post-transcriptional repression...