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Inhibition of Tumor Growth of Human Hepatocellular Carcinoma HepG2 Cells in a Nude Mouse Xenograft Model by the Total Flavonoids from Arachniodes exilis

332000, China 3School of Pharmacy and Life Sciences, Jiujiang University, No. 320 Xunyang Eastern Road, Jiujiang, Jiangxi 332000, China Correspondence should be addressed to Huimin Li; moc.qq@9377892991 ... and Dengzhao Jiang; moc.621@oahzgnedgnaij Received 9 August 2017; Revised 9 October 2017; Accepted 29 October 2017; Published 19 November 2017 Academic Editor: Célia Cabral Copyright © 2017 Huimin

Mimicking hypersensitivity pneumonitis as an uncommon initial presentation of chronic granulomatous disease in children

Dry cough, dyspenea and diffuse centrilobular nodules in both lungs of radiologic findings similar to hypersensitivity pneumonitis (HP) are rare initial presentation in chronic granulomatous disease (CGD). CGD is remarkable for increased susceptibility to bacterial and fungal infections as well as high sensitivity to inciting antigens such as Aspergillus species due to...

In Situ Synthesis of a Magnetic Graphene Platform for the Extraction of Benzimidazoles from Food Samples and Analysis by High-Performance Liquid Chromatography

Huimin Li, and Junyu Chen School of Biology and Chemistry, Xingyi Normal University for Nationalities, Xingyi 562400, China Correspondence should be addressed to Qianchun Zhang; moc.qq@gnahznuhcnaiq

Curcumin inhibits apoptosis by modulating Bax/Bcl-2 expression and alleviates oxidative stress in testes of streptozotocin-induced diabetic rats

Dong,2 Huimin Li,2 Jinyao Ni,2 Li Wan,2 Guoping Cai,2 Guorong Chen2 1Department of Pathology, Zhejiang Provincial Hospital of TCM, Hangzhou, 2Department of Pathology, The First Affiliated Hospital of

Genome-Wide Identification of miRNAs and Their Targets Involved in the Developing Internodes under Maize Ears by Responding to Hormone Signaling

Internode length is one of the decisive factors affecting plant height (PH) and ear height (EH), which are closely associated with the lodging resistance, biomass and grain yield of maize. miRNAs, currently recognized as important transcriptional/ post-transcriptional regulators, play an essential role in plant growth and development. However, their roles in developing internodes...

Effects and Molecular Mechanism of GST-Irisin on Lipolysis and Autocrine Function in 3T3-L1 Adipocytes

Irisin, which was recently identified as a myokine and an adipokine, transforms white adipose tissue to brown adipose tissue and has increasingly caught the attention of the medical and scientific community. However, the signaling pathway of irisin and the molecular mechanisms responsible for the lipolysis effect remain unclear. In this study, we established an efficient system...

Statistical Inference Methods for Two Crossing Survival Curves: A Comparison of Methods

A common problem that is encountered in medical applications is the overall homogeneity of survival distributions when two survival curves cross each other. A survey demonstrated that under this condition, which was an obvious violation of the assumption of proportional hazard rates, the log-rank test was still used in 70% of studies. Several statistical methods have been...

Physicochemical bases for protein folding, dynamics, and protein-ligand binding

Proteins are essential parts of living organisms and participate in virtually every process within cells. As the genomic sequences for increasing number of organisms are completed, research into how proteins can perform such a variety of functions has become much more intensive because the value of the genomic sequences relies on the accuracy of understanding the encoded gene...

Analysis of Intron Sequence Features Associated with Transcriptional Regulation in Human Genes

Although some preliminary work has revealed the potential transcriptional regulatory function of the introns in eukaryotes, additional evidences are needed to support this conjecture. In this study, we perform systemic analyses of the sequence characteristics of human introns. The results show that the first introns are generally longer and C, G and their dinucleotide...

Apoptosis Induction by the Total Flavonoids from Arachniodes exilis in HepG2 Cells through Reactive Oxygen Species-Mediated Mitochondrial Dysfunction Involving MAPK Activation

2014; Published 28 May 2014 Academic Editor: Thomas Efferth Copyright © 2014 Huimin Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits

Sleep Disturbances and Health-Related Quality of Life in Adults with Steady-State Bronchiectasis

Background Sleep disturbances are common in patients with chronic lung diseases, but little is known about the prevalence in patients with bronchiectasis. A cross sectional study was conducted to investigate the prevalence and determinants associated with sleep disturbances, and the correlation between sleep disturbances and quality of life (QoL) in adults with steady-state...

Energetic electrons associated with magnetic reconnection in the sheath of interplanetary coronal mass ejection

Magnetic reconnection is an important universal plasma dissipation process that converts magnetic energy into plasma thermal and kinetic energy, and simultaneously changes the magnetic field topology. In this paper, we report the first observation of energetic electrons associated with asymmetric reconnection in the sheath of an interplanetary coronal mass ejection. The magnetic...

Association Analysis of Genomic Loci Important for Grain Weight Control in Elite Common Wheat Varieties Cultivated with Variable Water and Fertiliser Supply

Grain weight, an essential yield component, is under strong genetic control and markedly influenced by the environment. Here, by genome-wide association analysis with a panel of 94 elite common wheat varieties, 37 loci were found significantly associated with thousand-grain weight (TGW) in one or more environments differing in water and fertiliser levels. Five loci were stably...

Sensitive fluorescence detection of nucleic acids based on isothermal circular strand-displacement polymerization reaction

Here we have developed a sensitive DNA amplified detection method based on isothermal strand-displacement polymerization reaction. This method takes advantage of both the hybridization property of DNA and the strand-displacement property of polymerase. Importantly, we demonstrate that our method produces a circular polymerization reaction activated by the target, which...

Using force spectroscopy analysis to improve the properties of the hairpin probe

The sensitivity of hairpin-probe-based fluorescence resonance energy transfer (FRET) analysis was sequence-dependent in detecting single base mismatches with different positions and identities. In this paper, the relationship between the sequence-dependent effect and the discrimination sensitivity of a single base mismatch was systematically investigated by fluorescence analysis...

SLC11A1 (Formerly NRAMP1) Gene Polymorphisms Associated with Pediatric Tuberculosis in China

Background.Tuberculosis is an urgent public health problem caused by Mycobacterium tuberculosis infection. Many factors, including host genetic factors, are involved in tuberculosis pathogenesis. The SLC11A1 gene (formerly NRAMP1) is a primary candidate for association with tuberculosis susceptibility. Methods.We examined the association between SLC11A1 polymorphisms and...