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Intestinal Stem Cells to Advance Drug Development, Precision, and Regenerative Medicine: A Paradigm Shift in Translational Research

Recent advances in our understanding of the intestinal stem cell niche and the role of key signaling pathways on cell growth and maintenance have allowed the development of fully differentiated epithelial cells in 3D organoids. Stem cell-derived organoids carry significant levels of proteins that are natively expressed in the gut and have important roles in drug transport and ...

Composite intestinal adenoma-microcarcinoid in the colon and rectum: a case series and historical review

Gon Youk 1 Hyun-Jung Kim 0 0 Department of Pathology, University of Inje College of Medicine, Sanggye Paik hospital , Dongil-ro 1342, Nowon-gu, Seoul , Republic of Korea 1 Department of Surgery, Daehang ... Foundation (20100557) to Hyun-Jung Kim. Availability of data and materials Please contact author for data requests. Authors’ contributions MJK performed histopathological evaluations and drafted the

Leg length change after opening wedge and closing wedge high tibial osteotomy: A meta-analysis

. Formal analysis: Hyun-Jung Kim, Dae-Hee Lee. Methodology: Hyun-Jung Kim, Dae-Hee Lee. Resources: Dae-Hee Lee. Supervision: Hyun-Jung Kim. Validation: Dae-Hee Lee. Writing ± original draft: Jun-Ho Kim

Effectiveness of beta-blockers depending on the genotype of congenital long-QT syndrome: A meta-analysis

Conceptualization: Jong-Il Choi, Young-Hoon Kim. 10 / 13 Data curation: Hyun Jung Kim. Formal analysis: Jinhee Ahn, Hyun Jung Kim, Hyeong Sik Ahn. Funding acquisition: Jong-Il Choi. Investigation: Jinhee Ahn ... , Jong-Il Choi, Kwang No Lee, Jaemin Shim, Hyeong Sik Ahn, Young-Hoon Kim. Methodology: Jinhee Ahn, Hyun Jung Kim, Kwang No Lee, Jaemin Shim, Hyeong Sik Ahn. Software: Jinhee Ahn. Supervision: Jong-Il

Transfer of the small diatoms Thalassiosira proschkinae and T. spinulata to the genus Minidiscus and their taxonomic re-description

: Joon Sang Park. Formal analysis: Joon Sang Park, Seung Won Jung, Jang-Seu Ki. Funding acquisition: Kyun-Woo Lee. Investigation: Joon Sang Park, Jang-Seu Ki, Ruoyu Guo, Hyun Jung Kim. Methodology ... : Joon Sang Park, Seung Won Jung. Resources: Joon Sang Park, Seung Won Jung. Supervision: Kyun-Woo Lee, Jin Hwan Lee. Validation: Ruoyu Guo, Kyun-Woo Lee, Jin Hwan Lee. Visualization: Hyun Jung Kim

Erratum to “Experimental study on natural convection heat transfer from horizontal cylinders with longitudinal plate fins”

Journal of Mechanical Science and Technology Hyun Jung Kim, Byoung Hoon An, Jinil Park and Dong-Kwon Kim *Corresponding author. Tel.: +82 31 219 3660, Fax.: +82 31 219 1611 - 0.387Ra1D/6 was

Incidence of Deep Vein Thrombosis and Venous Thromboembolism following TKA in Rheumatoid Arthritis versus Osteoarthritis: A Meta-Analysis

This meta-analysis was designed to compare the incidence of deep vein thrombosis (DVT) and venous thromboembolism (VTE) following total knee arthroplasty (TKA) in patients with rheumatoid arthritis (RA) and osteoarthritis (OA). All studies directly comparing the post-TKA incidence of DVT and/or VTE in patients with RA and OA were included. For all comparisons, odds ratios and 95% ...

Type of sexual intercourse experience and suicidal ideation, plans, and attempts among youths: a cross-sectional study in South Korea

Hyun Jung Kim 0 0 Department of Preventive Medicine, College of Medicine, Korea University , 73, Inchon-ro, Seongbuk-gu, Seoul 02841 , Korea 1 Department of School Health Education, Sanggye High School

Prognostic impact of EGFR mutation in non-small-cell lung cancer patients with family history of lung cancer

Background A family history can be a valuable tool in the era of precision medicine. Although a few studies have described an association of family history of lung cancer with EGFR activating mutation, their impact on survival of lung cancer patients is unclear. Methods The study included consecutive 829 non-small-cell lung cancer patients who received analysis of EGFR mutation in ...

A comparison of Ki-67 counting methods in luminal Breast Cancer: The Average Method vs. the Hot Spot Method

In spite of the usefulness of the Ki-67 labeling index (LI) as a prognostic and predictive marker in breast cancer, its clinical application remains limited due to variability in its measurement and the absence of a standard method of interpretation. This study was designed to compare the two methods of assessing Ki-67 LI: the average method vs. the hot spot method and thus to ...

Body Mass Index-Related Mortality in Patients with Type 2 Diabetes and Heterogeneity in Obesity Paradox Studies: A Dose-Response Meta-Analysis

Objective We conducted a systematic review and meta-analysis of studies to quantify the association between body mass index (BMI) and the risks of all-cause and cardiovascular mortality in patients with type 2 diabetes. Methods We included studies assessing the impact of BMI on all-cause and cardiovascular mortality in patients with type 2 diabetes. Data were combined using a ...

No Clinically Important Difference in Knee Scores or Instability Between Transtibial and Inlay Techniques for PCL Reconstruction: A Systematic Review

Background It is unclear whether the biomechanical superiority of the inlay technique over the transtibial technique, arising from avoidance of the killer turn at the graft-tunnel margin of the proximal tibia during posterior cruciate ligament (PCL) reconstruction, leads to better knee scores or greater knee stability. Questions/purposes This systematic review was designed to ...

Epicardial thoracoscopic ablation versus endocardial catheter ablation for management of atrial fibrillation: a systematic review and meta-analysis

(Hyun Jung Kim). The following variables were extracted from each included study for both the TA (intervention) and CA (control) groups: (i) demographic characteristics; (ii) number of patients who were ... Suk Kim) were resolved through discussion after review by a third author (Hyun Jung Kim). Statistical analysis Freedom from atrial arrhythmia without AAD over a follow-up of 12 months’ duration was

Comparison of Dorsal and Volar Percutaneous Approaches in Acute Scaphoid Fractures: A Meta-Analysis

The dorsal approach allows better central screw placement along the long axis of the scaphoid compared with the volar approach in managing acute scaphoid fractures. However, it is unclear whether the dorsal approach leads to better clinical outcomes than the volar approach. This meta-analysis compared clinical outcomes, including the incidence of nonunion, postoperative ...

The Value of Diffusion-Weighted Imaging in the Differential Diagnosis of Ovarian Lesions: A Meta-Analysis

Objectives The ability of contrast-enhanced MRI to distinguish between malignant and benign ovarian masses is limited. The aim of this meta-analysis is to evaluate the diagnostic performance of diffusion-weighted imaging (DWI) in differentiating malignant from benign ovarian masses. Methods A comprehensive literature search was performed in several authoritative databases to ...

Efficacy and Safety of Initial Combination Treatment of an Alpha Blocker with an Anticholinergic Medication in Benign Prostatic Hyperplasia Patients with Lower Urinary Tract Symptoms: Updated Meta-Analysis

Background There is still controversy as to whether initial combination treatment is superior to serial addition of anticholinergics after maintenance or induction of alpha blockers in benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS) Objective The objective of this study was to determine the benefits and safety of initial combination treatment of an alpha ...

Serial Changes of Quadriceps and Hamstring Muscle Strength Following Total Knee Arthroplasty: A Meta-Analysis

This meta-analysis was performed to analyze serial changes in thigh muscles, including quadriceps and hamstring muscles, from before to one year after total knee arthroplasty (TKA). All studies sequentially comparing isokinetic quadriceps and hamstring muscle strengths between the TKA side and the contralateral uninjured limb were included in this meta-analysis. Five studies with 7 ...