Activation of the NLRP3 inflammasome is crucial for immune defense, but improper and excessive activation causes inflammatory diseases. We previously reported that Pyk2 is essential for NLRP3 inflammasome activation. Here we show that the Src-family kinases (SFKs)-Cbl axis plays a pivotal role in suppressing NLRP3 inflammasome activation in response to stimulation by nigericin or...
The inflammasome adaptor protein, ASC, contributes to both innate immune responses and inflammatory diseases via self-oligomerization, which leads to the activation of the protease, caspase-1. Here, we report that the cytosolic tyrosine kinases, FAK and Pyk2, are differentially involved in NLRP3 and AIM2 inflammasome activation. The inhibition of FAK and Pyk2 with RNA...
Background Overexpression of heterogeneous nuclear ribonucleoprotein K (hnRNP K), a DNA/RNA binding protein, is associated with metastasis in nasopharyngeal carcinoma (NPC). However, the mechanisms underlying hnRNP K-mediated metastasis is unclear. The aim of the present study was to determine the role of matrix metalloproteinase (MMP) in hnRNP K-mediated metastasis in NPC...
, 5, Fu-Ching St, Taoyuan, Kwei-Shan, 333, TaiwanKai-Ping Chang AuthorsSearch for I-Che Chung in:PubMed • Google Scholar Search for Lih-Chyang Chen in:PubMed • Google Scholar Search for An-Ko Chung ... . All authors read and approved the final manuscript. I-Che Chung, Lih-Chyang Chen contributed equally to this work. Electronic supplementary material Additional file 1: Table S1: Sequence of
