Advanced search    

Search: authors:"I. Chou"

10 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

Harnessing the early post-injury inflammatory responses for cardiac regeneration

Cardiac inflammation is considered by many as the main driving force in prolonging the pathological condition in the heart after myocardial infarction. Immediately after cardiac ischemic injury, neutrophils are the first innate immune cells recruited to the ischemic myocardium within the first 24 h. Once they have infiltrated the injured myocardium, neutrophils would then secret ...

Bubbles Are Departures from Equilibrium Housing Markets: Evidence from Singapore and Taiwan

The housing prices in many Asian cities have grown rapidly since mid-2000s, leading to many reports of bubbles. However, such reports remain controversial as there is no widely accepted definition for a housing bubble. Previous studies have focused on indices, or assumed that home prices are lognomally distributed. Recently, Ohnishi et al. showed that the tail-end of the ...

Flow and Performance of an Air-curtain Biological Safety Cabinet

Using laser-assisted smoke flow visualization and tracer gas concentration detection techniques, this study examines aerodynamic flow properties and the characteristics of escape from containment, inward dispersion, and cross-cabinet contamination of a biological safety cabinet installed with an air curtain across the front aperture. The experimental method partially simulates the ...

Hydrophilic Aromatic Residue and in silico Structure for Carbohydrate Binding Module

, decision to publish, or preparation of the manuscript. Competing Interests: Dr. Wei-I Chou contributed to this study as a PhD student of the corresponding author in Institute of Molecular and Cellular ... database is open to the public for internet access. The authors declare that this study is free from any commercial or financial interest. The employment of Dr. Wei-I Chou does not alter the authors

Two Unique Ligand-Binding Clamps of Rhizopus oryzae Starch Binding Domain for Helical Structure Disruption of Amylose

. Competing Interests: Dr. Wei-I Chou contributed to this study since he was a PhD student of Dr. Chang in the Institute of Molecular and Cellular Biology and Department of Medical Science, National Tsing Hua ... . The employment of Dr. Wei-I Chou does not alter the authors adherence to all the PLoS ONE policies on sharing data and materials. Starch is the primary form of carbohydrate storage in plant tubers and

Focused Ultrasound-Induced Blood–Brain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment: A Preclinical Study

The purpose of this study is to assess the preclinical therapeutic efficacy of magnetic resonance imaging (MRI)-monitored focused ultrasound (FUS)-induced blood-brain barrier (BBB) disruption to enhance Temozolomide (TMZ) delivery for improving Glioblastoma Multiforme (GBM) treatment. MRI-monitored FUS with microbubbles was used to transcranially disrupt the BBB in brains of Fisher ...

Feature-incorporated alignment based ligand-binding residue prediction for carbohydrate-binding modules

Motivation: Carbohydrate-binding modules (CBMs) share similar secondary and tertiary topology, but their primary sequence identity is low. Computational identification of ligand-binding residues allows biologists to better understand the protein–carbohydrate binding mechanism. In general, functional characterization can be alternatively solved by alignment-based manners. As ...

Role of the linker region in the expression of Rhizopus oryzae glucoamylase

Background Rhizopus oryzae glucoamylase (RoGA) consists of three domains: an amino (N)-terminal raw starch-binding domain (SBD), a glycosylated linker domain, and a carboxy (C)-terminal catalytic domain. The 36-amino-acid linker region (residues 132–167) connects the two functional domains, but its structural and functional roles are unclear. Results To characterize the linker ...

Novel magnetic/ultrasound focusing system enhances nanoparticle drug delivery for glioma treatment

Malignant glioma is a common and severe primary brain tumor with a high recurrence rate and an extremely high mortality rate within 2 years of diagnosis, even when surgical, radiological, and chemotherapeutic interventions are applied. Intravenously administered drugs have limited use because of their adverse systemic effects and poor blood–brain barrier penetration. Here, we ...

REMUS: a tool for identification of unique peptide segments as epitopes

We provide a ‘REMUS’ (reinforced merging techniques for unique peptide segments) web server for identification of the locations and compositions of unique peptide segments from a set of protein family sequences. Different levels of uniqueness are determined according to substitutional relationship in the amino acids, frequency of appearance and biological properties such as ...