A low calcium intake is a well-known factor that influences the bone mineral density (BMD) maintenance. In the presence of inadequate calcium intake, secondary hyperparathyroidism develops, leading to an increased bone turnover and fracture risk. To assess the dietary calcium intake in relation with osteoporosis and fragility fracture in a cohort of Italian individuals evaluated...
Vitamin D deficiency has been suggested to favor a poorer outcome of Coronavirus disease-19 (COVID-19). We aimed to assess if 25-hydroxyvitamin-D (25OHD) levels are associated with interleukin 6 (IL-6) levels and with disease severity and mortality in COVID-19. We prospectively studied 103 in-patients admitted to a Northern-Italian hospital (age 66.1 ± 14.1 years, 70 males) for...
Update on denosumab in the management of postmenopausal osteoporosis: patient preference and adherence Elisa Cairoli,1,2 Cristina Eller-Vainicher,1 Iacopo Chiodini1,2 1Unit of Endocrinology and Metabolic Diseases, Fondazione IRCCS Ca’ Granda – Ospedale Maggiore Policlinico, Padiglione Granelli, Milan, Italy; 2Department of Clinical Sciences and Community Health, University of...
Background The presence of hypovitaminosis D in patients with autoimmune bullous skin diseases, such as pemphigus vulgaris (PV) and bullous pemphigoid (BP), is debated. In a previous study we found an increased prevalence of vertebral fractures (VFx) and hypovitaminosis D in PV and BP patients. The present study extends the sample size of the previous one, for investigating the...
OBJECTIVE: To describe the biochemical effects of an over-supplementation of vitamin D3 in two patients with primary hyperparathyroidism (PHPT). DESIGN: Two patients (A and B) with PHPT took erroneously 2,400,000U (300,000 U/day for 8 days) and 4,500,000U (300,000 U/day for 15 days) of cholecalciferol, respectively. They were followed for 4 months and ionized calcium, creatinine...
The presence of hypovitaminosis D in patients with autoimmune bullous skin diseases, such as pemphigus vulgaris (PV) and bullous pemphigoid (BP), is debated. In a previous study we found an increased prevalence of vertebral fractures (VFx) and hypovitaminosis D in PV and BP patients. The present study extends the sample size of the previous one, for investigating the 25...
Context Patients with adrenal incidentalomas (AI) may experience detrimental consequences due to a minimal cortisol excess sustained by adrenal adenoma. SNPs of the glucocorticoid receptor gene (NR3C1) modulate individual sensitivity to glucocorticoids and may interfere with the clinical presentation. Objective To compare the frequency of N363S, ER22/23EK and BclI SNPs in...
diabetes complications and physiological and pathological cerebral aging. IACOPO CHIODINI, MD1 GUIDO ADDA, MD2 PAOLO BECK-PECCOZ1 EMANUELA ORSI, MD1 BRUNO AMBROSI3 MAURA AROSIO1,2
VOLHA V. ZHUKOUSKAYA CRISTINA ELLER-VAINICHER VOLHA V. VADZIANAVA ALLA P. SHEPELKEVICH PHD IRINA V. ZHURAVA GALINA G. KOROLENKO PHD OLGA B. SALKO ELISA CAIROLI PAOLO BECK-PECCOZ IACOPO CHIODINI
CRISTINA ELLER-VAINICHER VOLHA V. ZHUKOUSKAYA YURY V. TOLKACHEV SERGEI S. KORITKO ELISA CAIROLI ENZO GROSSI PAOLO BECK-PECCOZ IACOPO CHIODINI ALLA P. SHEPELKEVICH PHD OBJECTIVEdTo investigate
Background It is known that bone mineral density (BMD) predicts the fracture's risk only partially and the severity and number of vertebral fractures are predictive of subsequent osteoporotic fractures (OF). Spinal deformity index (SDI) integrates the severity and number of morphometric vertebral fractures. Nowadays, there is interest in developing algorithms that use traditional...
OBJECTIVEThe diagnosis of hypothalamic-pituitary-adrenal insufficiency (HPAI) is a major clinical challenge. The gold standard procedure remains insulin tolerance test (ITT). This study aimed to evaluate the usefulness of standard-dose corticotrophin stimulation test (SDCT) in diagnosing HPAI.DESIGNIn this prospective study we performed SDCT and ITT in 55 consecutive patients...
OBJECTIVE—The presence of an enhanced cortisol secretion in patients with type 2 diabetes is debated. In type 2 diabetic subjects, cortisol secretion was found to be associated with the complications and metabolic control of diabetes. We evaluated cortisol secretion in 170 type 2 diabetic subjects and in 71 sex-, age-, and BMI-matched nondiabetic subjects. RESEARCH DESIGN AND...
