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Secukinumab Versus Adalimumab for Psoriatic Arthritis: Comparative Effectiveness up to 48 Weeks Using a Matching-Adjusted Indirect Comparison

article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published. Peter Nash, Iain B. McInnes, Philip J. Mease, Howard Thom, Kunal Gandhi ... , UK, and was funded by Novartis Pharma AG, Basel, Switzerland. Disclosures. Peter Nash has received grant/ research support and consulting fees from Novartis. Iain B. McInnes has received consulting

Future therapeutic targets in rheumatoid arthritis?

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by persistent joint inflammation. Without adequate treatment, patients with RA will develop joint deformity and progressive functional impairment. With the implementation of treat-to-target strategies and availability of biologic therapies, the outcomes for patients with RA have significantly improved...

Secukinumab: A New Treatment Option for Psoriatic Arthritis

and other chronic and disabling rheumatic diseases. ACKNOWLEDGMENTS Iain B. McInnes acknowledges support from Arthritis Research UK for the ongoing rheumatology program in University of Glasgow ... Healthcare Ltd. Support for this assistance was funded by Novartis Pharma. Philip Mease and Iain B. McInnes meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this

Identification of Urinary Peptide Biomarkers Associated with Rheumatoid Arthritis

Early diagnosis and treatment of rheumatoid arthritis are associated with improved outcomes but current diagnostic tools such as rheumatoid factor or anti-citrullinated protein antibodies have shown limited sensitivity. In this pilot study we set out to establish a panel of urinary biomarkers associated with rheumatoid arthritis using capillary electrophoresis coupled to mass...

The biological and clinical importance of the 'new generation' cytokines in rheumatic diseases

A better understanding of cytokine biology over the last two decades has allowed the successful development of cytokine inhibitors against tumour necrosis factor and interleukin (IL)-1 and IL-6. The introduction of these therapies should be considered a breakthrough in the management of several rheumatic diseases. However, many patients will exhibit no or only partial response to...

Th17 Effector Cells Support B Cell Responses Outside of Germinal Centres

Th17 cells are pro-inflammatory CD4+T cells, which are important in immune responses against fungal pathogens and extracellular bacteria and have also been implicated in various autoimmune syndromes. However, their role in supporting B cell responses in these scenarios remains unclear, representing a significant lapse in our understanding of the role Th17 play in vaccine...

MiR-155 Has a Protective Role in the Development of Non-Alcoholic Hepatosteatosis in Mice

. McInnes 0 Mariola Kurowska-Stolarska 0 Massimo Federici, University of Tor Vergata, Italy 0 1 Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences, University of

Introduction

Arthritis Res Ther 1478-6354 Corresponding author: Iain B McInnes (e-mail: ) 0 1 0 Iain B McInnes, Centre for Rheumatic Diseases, University of Glasgow , 10 Alexandra Parade, Glasgow G312ER

Looking through the 'window of opportunity': is there a new paradigm of podiatry care on the horizon in early rheumatoid arthritis?

Hennessy 0 Martijn PM Steultjens 0 Iain B McInnes Deborah E Turner 0 0 Musculoskeletal Rehabilitation Research Group, Institute of Applied Health Research, School of Health, Glasgow Caledonian University

T Cell Maturation in Inflammatory Synovitis

of Rheumatology, Humboldt University of Berlin , Germany 9 Lynne C Tetlow and David E Woolley University Department of Medicine, Manchester Royal Infirmary , M13 9WL , UK 10 Iain B McInnes Centre for

Do the pleiotropic effects of statins in the vasculature predict a role in inflammatory diseases?

author: Iain B McInnes 0 Department of Vascular Biochemistry, Glasgow Royal Infirmary , Glasgow , UK 1 Centre for Rheumatic Diseases, Glasgow Royal Infirmary , Glasgow , UK Pleiotropic effects are now

Interleukin-18: a therapeutic target in rheumatoid arthritis?

Corresponding author: Iain B McInnes 0 0 0 Division of Immunology , Infection and Inflammation , University of Glasgow , UK Interleukin 18 (IL-18), a member of the IL-1 superfamily of cytokines has

Soluble ST2 Associates with Diabetes but Not Established Cardiovascular Risk Factors: A New Inflammatory Pathway of Relevance to Diabetes?

Preliminary data mostly from animal models suggest the sST2/IL-33 pathway may have causal relevance for vascular disease and diabetes and thus point to a potential novel inflammatory link to cardiometabolic disease. However, the characterisation of sST2 levels in terms of metabolic or vascular risk in man is completely lacking. We sought to address this gap via a comprehensive...

Cell-cell interactions in synovitis: Interactions between T lymphocytes and synovial cells

Rheumatic Diseases and Department of Immunology and Bacteriology, University of Glasgow , Glasgow , UK 1 Authors' affiliations: Iain B McInnes (Glasgow Royal Infirmary , Glasgow , UK) , and Bernard P Leung

Enumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis

Dendritic cells (DCs) comprise heterogeneous subsets of professional antigen-presenting cells, linking innate and adaptive immunity. Analysis of DC subsets has been hampered by a lack of specific DC markers and reliable quantitation assays. We characterised the immunophenotype and functional characteristics of psoriatic arthritis (PsA)-derived and rheumatoid arthritis (RA...

Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren's syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate

IL-18, an immunoregulatory and proinflammatory cytokine, has been shown to play an important pathogenic role in Th1-driven autoimmune disorders. In this study, we evaluated the circulating levels and salivary-gland expression of IL-18 in patients with Sjögren's syndrome (SS), a mainly Th1-mediated disease. IL-18 serum levels were measured by ELISA in 37 patients with primary SS...