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12 papers found.
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Association between urinary free light chains and progression to end stage renal disease in chronic kidney disease

research fellowship. Author Contributions Conceptualization: Iain Chapple, Indranil Dasgupta, Stephen J. Harding, Charles J. Ferro, Paul Cockwell. Data curation: Anthony Fenton, Mark D. Jesky, Rachel ... Webster, Stephanie J. Stringer, Punit Yadav, Indranil Dasgupta, Stephen J. Harding, Charles J. Ferro, Paul Cockwell. Formal analysis: Anthony Fenton. Funding acquisition: Stephen J. Harding, Charles J

Validating the use of bioimpedance spectroscopy for assessment of fluid status in children

, Leeds Teaching Hospitals NHS Trust , Leeds , UK 2 Heartlands Hospital and University of Birmingham , Birmingham , UK 3 Indranil Dasgupta 4 Department of Pediatrics, Institute of Clinical Sciences

Health-Related Quality of Life Impacts Mortality but Not Progression to End-Stage Renal Disease in Pre-Dialysis Chronic Kidney Disease: A Prospective Observational Study

Background Chronic kidney disease (CKD) is associated with reduced health-related quality of life (HRQL). However, the relationship between pre-dialysis CKD, HRQL and clinical outcomes, including mortality and progression to end-stage renal disease (ESRD) is unclear. Methods All 745 participants recruited into the Renal Impairment In Secondary Care study to end March 2014 were...

Does community-wide chronic kidney disease management improve patient outcomes?

Background The number of patients starting renal replacement therapy (RRT) is increasing in England, as it is worldwide. Improvements in the management of chronic kidney disease (CKD) across communities to alter this trend are a public health priority. We have prospectively studied changes in the incidence and modality of treatment for end-stage renal disease following the...

National survey of heparin-induced thrombocytopenia in the haemodialysis population of the UK population

Background. Heparin-induced thrombocytopoenia (HIT) type II is an antibody-mediated, drug-induced thrombocytopenia which is associated with significant morbidity and mortality. Several case reports and small series have described the occurrence of HIT type II in the haemodialysis population and the challenges associated with it. Some of these reports raise the possibility of a...

Renal artery sympathetic denervation: observations from the UK experience

Background Renal denervation (RDN) may lower blood pressure (BP); however, it is unclear whether medication changes may be confounding results. Furthermore, limited data exist on pattern of ambulatory blood pressure (ABP) response—particularly in those prescribed aldosterone antagonists at the time of RDN. Methods We examined all patients treated with RDN for treatment-resistant...

RNA-interference in rice against Rice tungro bacilliform virus results in its decreased accumulation in inoculated rice plants

Rice tungro is a viral disease seriously affecting rice production in South and Southeast Asia. Tungro is caused by the simultaneous infection in rice of Rice tungro bacilliform virus (RTBV), a double-stranded DNA virus and Rice tungro spherical virus (RTSV), a single-stranded RNA virus. To apply the concept of RNA-interference (RNAi) for the control of RTBV infection, transgenic...

Pathophysiology and clinical studies in CKD 1-5

Introduction and Aims: Transcatheter aortic valve replacement (TAVR) is an established percutaneous technique for the management of patients with severe symptomatic aortic stenosis at high operative risk with or without chronic kidney disease (CKD). Iodine contrast administration, rapid cardiac pacing and use of large core catheters in putative calcified arteries are among the...

Diabetes - clinical studies

Introduction and Aims:Cardiovascular disease is common in CKD patients and is the most frequent cause of death. Diabetic CKD patients are at especially high risk for cardiovascular mortality. PWV assesses arterial stiffness and is a predictor of both mortality and cardiovascular outcomes. Some studies suggest that vascular injury is so advanced at the dialysis stage that the...