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Can erythrocytes release biologically active NO?

Under physiological conditions, endothelial cells and the endothelial nitric oxide (NO) synthase (eNOS) are the main source of NO in the cardiovascular system. However, several other cell types have also been implicated in the NO-dependent regulation of cell function, including erythrocytes. NO derived from red blood cells has been proposed to regulate erythrocyte membrane...

Methylglyoxal Induces Platelet Hyperaggregation and Reduces Thrombus Stability by Activating PKC and Inhibiting PI3K/Akt Pathway

Diabetes is characterized by a dysregulation of glucose homeostasis and platelets from patients with diabetes are known to be hyper-reactive and contribute to the accelerated development of vascular diseases. Since many of the deleterious effects of glucose have been attributed to its metabolite methylgyloxal (MG) rather than to hyperglycemia itself, the aim of the present study...

Insulin, Insulin Resistance, and Platelet Signaling in Diabetes

VOAHANGINIRINA RANDRIAMBOAVONJY PHD INGRID FLEMING PHD I syndrome are associated with a pronsulin resistance and the metabolic thrombotic state that contributes to the pathogenesis and progression

From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on “New frontiers in cardiovascular research”

In this meeting report, particularly addressing the topic of protection of the cardiovascular system from ischemia/reperfusion injury, highlights are presented that relate to conditioning strategies of the heart with respect to molecular mechanisms and outcome in patients’ cohorts, the influence of co-morbidities and medications, as well as the contribution of innate immune...

Nitric Oxide-Induced Activation of the AMP-Activated Protein Kinase α2 Subunit Attenuates IκB Kinase Activity and Inflammatory Responses in Endothelial Cells

Background In endothelial cells, activation of the AMP-activated protein kinase (AMPK) has been linked with anti-inflammatory actions but the events downstream of kinase activation are not well understood. Here, we addressed the effects of AMPK activation/deletion on the activation of NFκB and determined whether the AMPK could contribute to the anti-inflammatory actions of nitric...

11,12-EET Stimulates the Association of BK Channel α and β1 Subunits in Mitochondria to Induce Pulmonary Vasoconstriction

Andreas Daiber 0 Ingrid Fleming 0 Rory Edward Morty, University of Giessen Lung Center, Germany 0 1 Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University , Frankfurt am Main

Meeting report from the 2nd International Symposium on New Frontiers in Cardiovascular Research. Protecting the cardiovascular system from ischemia: between bench and bedside

Ca2?-activated proteases that are required for the limited proteolysis of several substrate proteins and subsequent alterations in platelet signaling. Ingrid Fleming (Germany) has found that the

Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation

Ingrid Fleming Ralf P Brandes Peter W Reeh Clifford J Woolf Gerd Geisslinger 0 Klaus Scholich 0 0 Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University

Mena/VASP and αII-Spectrin complexes regulate cytoplasmic actin networks in cardiomyocytes and protect from conduction abnormalities and dilated cardiomyopathy

Feller Ingrid Fleming 0 Thomas Renn Stefan Frantz Andreas Unger Kai Schuh 1 0 Institute for Vascular Signalling, Goethe-University Frankfurt , D-60590 Frankfurt , Germany 1 Institute of Physiology I

Role of PECAM-1 in the shear-stress-induced activation of Akt and the endothelial nitric oxide synthase (eNOS) in endothelial cells

Ingrid Fleming Beate Fisslthaler Madhulika Dixit Rudi Busse - The application of fluid shear stress to endothelial cells elicits the formation of nitric oxide (NO) and phosphorylation of the

Increased Cytochrome P4502E1 Expression and Altered Hydroxyeicosatetraenoic Acid Formation Mediate Diabetic Vascular Dysfunction: Rescue by Guanylyl-Cyclase Activation

Andreas Sch afer Paolo Galuppo Daniela Fraccarollo Christian Vogt Julian D. Widder Julia Pfrang Piet Tas Eduardo Barbosa-Sicard Hartmut Ruetten Georg Ertl Ingrid Fleming Johann Bauersachs