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27 papers found.
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Persistent, Albeit Reduced, Chronic Inflammation in Persons Starting Antiretroviral Therapy in Acute HIV Infection

Background. Serious non-AIDS events cause substantial disease and death despite human immunodeficiency virus (HIV) suppression with antiretroviral therapy (ART). Biomarkers of inflammation, coagulation cascade activation, and fibrosis predict these end-organ events. We aimed to determine whether ART initiation during acute HIV infection would attenuate changes in these biomarker ...

Cytomegalovirus immune reconstitution inflammatory syndrome manifesting as acute appendicitis in an HIV-infected patient

Background Appendicitis occurs with increased frequency in HIV infected compared to HIV uninfected persons. CMV-related appendicitis specifically presents with typical appendicitis symptoms including surgical abdomen, fever and leukocytosis and may have a more severe course with higher mortality than other types of infective appendicitis. We report the first case of CMV ...

Idiopathic CD4 lymphocytopenia: a case of missing, wandering or ineffective T cells

Dimitrios Zonios Virginia Sheikh 0 Irini Sereti 0 0 Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health , 10 Center Drive, Bethesda

Quantifying and Predicting the Effect of Exogenous Interleukin-7 on CD4+T Cells in HIV-1 Infection

-Pierre Sekaly Michael M. Lederman Irini Sereti Daniel Commenges Yves Le vy Becca Asquith, Imperial College London, United Kingdom Exogenous Interleukin-7 (IL-7), in supplement to antiretroviral therapy

Monocyte-Activation Phenotypes Are Associated With Biomarkers of Inflammation and Coagulation in Chronic HIV Infection

Gibson 5 W. Keith Henry 0 5 Ken Lichtenstein 4 Nur F. Önen 5 Erna Kojic 3 Pragna Patel 7 John T. Brooks 7 Irini Sereti 2 Jason V. Baker 0 6 for the Study to Understand the Natural History of HIV/AIDS in

Evidence for Innate Immune System Activation in HIV Type 1–Infected Elite Controllers

Background. Elite controllers maintain high CD4+ T-cell counts and suppress plasma human immunodeficiency virus (HIV) viremia in the absence of antiretroviral therapy (ART). It is unclear whether levels of biomarkers associated with coagulation, monocyte activation, and inflammation, which are linked to HIV-associated mortality, differ among elite controllers, ART recipients with ...

HIV Infection and the Gut: Scarred for Life?

Sarah W. Read 1 Irini Sereti 0 0 Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland 1 Division of Acquired

Cerebrospinal Fluid HIV-1 Compartmentalization in a Patient With AIDS and Acute Varicella-Zoster Virus Meningomyeloradiculitis

We report a case of AIDS presenting as varicella-zoster virus (VZV) meningomyeloradiculitis associated with human immunodeficiency virus (HIV) quasispecies compartmentalization within the cerebrospinal fluid (CSF), and a CSF viral load that was 1 log higher than in peripheral blood. Prolonged antiviral therapy for both VZV and HIV type 1 was associated with partial resolution.

Mycobacterial Antigen Driven Activation of CD14++CD16− Monocytes Is a Predictor of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome

Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is an aberrant inflammatory response occurring in a subset of TB-HIV co-infected patients initiating anti-retroviral therapy (ART). Here, we examined monocyte activation by prospectively quantitating pro-inflammatory plasma markers and monocyte subsets in TB-HIV co-infected patients from a ...

Initiation of ART during Early Acute HIV Infection Preserves Mucosal Th17 Function and Reverses HIV-Related Immune Activation

of MMC. The work of Irini Sereti was supported by Intramural Research Program of NIAID/NIH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of

Biomarkers of Inflammation and Coagulation Are Associated With Mortality and Hepatitis Flares in Persons Coinfected With HIV and Hepatitis Viruses

Sher 3 Sharon R. Lewin 9 Irini Sereti () 1 for the INSIGHT Study Group 0 SAIC Frederick, National Cancer Institute , Frederick, Maryland 1 Clinical and Molecular Retrovirology Section, Laboratory of

Lack of Compartmentalization of HIV-1 Quasispecies Between the Gut and Peripheral Blood Compartments

Compartmental differences in human immunodeficiency virus type 1 (HIV-1) between the gut and peripheral blood and within the gut were examined. Biopsy specimens from the colon and ileum and peripheral blood samples were collected from chronically HIV-1–infected individuals. HIV-1 envelope sequences were examined from cell-associated DNA and RNA and virion RNA. Phylogenetic analysis ...

Decreased Interleukin 7 Responsiveness of T Lymphocytes in Patients With Idiopathic CD4 Lymphopenia

Background. Elevated serum interleukin 7 (IL-7) levels are observed in lymphopenic conditions, including idiopathic CD4 lymphopenia (ICL), which is characterized by CD4 lymphopenia in the absence of human immunodeficiency virus infection or other known immunodeficiency. Methods. To test whether defective IL-7 signaling could be an etiologic or contributing factor in ICL, peripheral ...

Decreases in Colonic and Systemic Inflammation in Chronic HIV Infection after IL-7 Administration

Despite antiretroviral therapy (ART), some HIV-infected persons maintain lower than normal CD4+ T-cell counts in peripheral blood and in the gut mucosa. This incomplete immune restoration is associated with higher levels of immune activation manifested by high systemic levels of biomarkers, including sCD14 and D-dimer, that are independent predictors of morbidity and mortality in ...

Elevated Interleukin 8 and T-Helper 1 and T-Helper 17 Cytokine Levels Prior to Antiretroviral Therapy in Participants Who Developed Immune Reconstitution Inflammatory Syndrome During ACTG A5164

Background. Immune reconstitution inflammatory syndrome (IRIS) reflects an aberrant immune response that can develop in human immunodeficiency virus–infected patients initiating antiretroviral therapy (ART). Its pathogenesis remains unclear. Methods. We performed a nested case-control study using specimens from ACTG A5164. We compared plasma biomarkers and T-cell subsets in 19 IRIS ...

Higher Levels of CRP, D-dimer, IL-6, and Hyaluronic Acid Before Initiation of Antiretroviral Therapy (ART) Are Associated With Increased Risk of AIDS or Death

Background. Substantial morbidity occurs during the first year of antiretroviral therapy (ART) in persons with advanced human immunodeficiency virus (HIV) disease despite HIV suppression. Biomarkers may identify high-risk groups. Methods. Pre-ART and 1-month samples from an initial ART trial were evaluated for biomarkers associated with AIDS events or death within 1–12 months. Case ...

Paradoxical Tuberculosis Immune Reconstitution Inflammatory Syndrome (TB-IRIS) in HIV Patients with Culture Confirmed Pulmonary Tuberculosis in India and the Potential Role of IL-6 in Prediction

Background The incidence, manifestations, outcome and clinical predictors of paradoxical TB-IRIS in patients with HIV and culture confirmed pulmonary tuberculosis (PTB) in India have not been studied prospectively. Methods HIV+ patients with culture confirmed PTB started on anti-tuberculosis therapy (ATT) were followed prospectively after anti-retroviral therapy (ART) initiation. ...

Disseminated Nocardiosis in a Patient with X-Linked Chronic Granulomatous Disease and Human Immunodeficiency Virus Infection

Irini Sereti Steven M. Holland 0 0 Host Defenses, National Institutes of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland We report the first case of HIV infection

Immunopathogenesis of Human Immunodeficiency Virus: Implications for Immune-Based Therapies

Allergy and Infectious Diseases, National Institutes of Health , Bldg. 10, Rm. 11S-231, 10 Center Dr., MSC 1876, Bethesda MD 20892 1 Irini Sereti and H. Clifford Lane Cellular and Molecular Retrovirology

The Effect of Leflunomide on Cycling and Activation of T-Cells in HIV-1-Infected Participants

Catherine Rehm 0 Irini Sereti 0 Sean Emery, University of New South Wales, Australia 0 1 Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda