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The p75NTR-mediated effect of nerve growth factor in L6C5 myogenic cells

ObjectiveDuring muscle development or regeneration, myocytes produce nerve growth factor (NGF) as well as its tyrosine-kinase and p75-neurotrophin (p75NTR) receptors. It has been published that the p75NTR receptor could represent a key regulator of NGF-mediated myoprotective effect on satellite cells, but the precise function of NGF/p75 signaling pathway on myogenic cell...

Physical Exercise and Redox Balance in Type 2 Diabetics: Effects of Moderate Training on Biomarkers of Oxidative Stress and DNA Damage Evaluated through Comet Assay

,2 Ivan Dimauro,1 Barbara Tavazzi,3 Paolo Parisi,1 and Daniela Caporossi1 1Department of Movement, Human and Health Sciences, University of Rome “Foro Italico”, 00135 Rome, Italy 2Department of

A simple protocol for the subcellular fractionation of skeletal muscle cells and tissue

. Authors’ information Ivan Dimauro and Timothy Pearson joint first author. Acknowledgements Funding by the MRC (TP, MJJ) and University of Rome “Foro Italico” (ID, DC) are gratefully acknowledged. 1. De

Platelet-Rich Plasma and Skeletal Muscle Healing: A Molecular Analysis of the Early Phases of the Regeneration Process in an Experimental Animal Model

Platelet-rich plasma (PRP) has received increasing interest in applied medicine, being widely used in clinical practice with the aim of stimulating tissue healing. Despite the reported clinical success, there is still a lack of knowledge when considering the biological mechanisms at the base of the activity of PRP during the process of muscle healing. The aim of the present study...

In Vitro Effects of Beta-2 Agonists on Skeletal Muscle Differentiation, Hypertrophy, and Atrophy

Background Beta-2 agonists are widely used in the treatment of asthma and chronic obstructive pulmonary disease for their effect on airway smooth muscle relaxation. They also act on skeletal muscle, although their reported ergogenic effect is controversial. Aim To evaluate the in vitro effects of short-acting and long-acting beta-2 agonists on adrenergic receptor (ADR) expression...