The conserved MICOS complex functions as a primary determinant of mitochondrial inner membrane structure. We address the organization and functional roles of MICOS and identify two independent MICOS subcomplexes: Mic27/Mic10/Mic12, whose assembly is dependent on respiratory complexes and the mitochondrial lipid cardiolipin, and Mic60/Mic19, which assembles independent of these...
journals • PubMed • Google ScholarSearch for J. Michael McCaffery in:Nature Research journals • PubMed • Google ScholarSearch for Takanari Inoue in:Nature Research journals • PubMed • Google Scholar
Mitochondrial fission in eukaryotes is mediated by protein complexes that encircle and divide mitochondrial tubules. In budding yeast, fission requires the membrane-anchored protein Fis1 and the dynamin-related GTPase Dnm1. Dnm1 is recruited to mitochondria via interactions with the adaptor proteins Caf4 and Mdv1, which bind directly to Fis1. Unlike Mdv1, a function for Caf4 in...
Background Biofuels offer a viable alternative to petroleum-based fuel. However, current methods are not sufficient and the technology required in order to use lignocellulosic biomass as a fermentation substrate faces several challenges. One challenge is the need for a robust fermentative microorganism that can tolerate the inhibitors present during lignocellulosic fermentation...
Allison B. Jenkins 1 J. Michael McCaffery 0 Mark Van Doren ) 1 0 Integrated Imaging Center, Department of Biology, Mudd Hall, Johns Hopkins University , 3400 N. Charles Street, Baltimore, MD 21218
Debarati Mukherjee Brian G. Coon Daniel F. Edwards III Claudia B. Hanna Silvia A. Longhi J. Michael McCaffery Beverly Wendland Lilia A. Retegui Erfei Bi R. Claudio Aguilar
Debarati Mukherjee Brian G. Coon Daniel F. Edwards III Claudia B. Hanna Silvia A. Longhi J. Michael McCaffery Beverly Wendland Lilia A. Retegui Erfei Bi R. Claudio Aguilar - The yeast endocytic
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant familial Parkinson's disease (PD) and also contribute to idiopathic PD. LRRK2 mutations represent the most common cause of PD with clinical and neurochemical features that are largely indistinguishable from idiopathic disease. Currently, transgenic mice expressing wild-type or disease...
. Caldwell George W. Bell Ernest Fraenkel Antony A. Cooper Guy A. Caldwell J. Michael McCaffery Jean-Christophe Rochet Susan Lindquist () -Synuclein (-syn) is a small lipid-binding protein involved in vesicle