Search: authors:"J Michael McCaffery"

MICOS coordinates with respiratory complexes and lipids to establish mitochondrial inner membrane architecture

The conserved MICOS complex functions as a primary determinant of mitochondrial inner membrane structure. We address the organization and functional roles of MICOS and identify two independent MICOS subcomplexes: Mic27/Mic10/Mic12, whose assembly is dependent on respiratory complexes and the mitochondrial lipid cardiolipin, and Mic60/Mic19, which assembles independent of these...

The Mitochondrial Fission Adaptors Caf4 and Mdv1 Are Not Functionally Equivalent

Mitochondrial fission in eukaryotes is mediated by protein complexes that encircle and divide mitochondrial tubules. In budding yeast, fission requires the membrane-anchored protein Fis1 and the dynamin-related GTPase Dnm1. Dnm1 is recruited to mitochondria via interactions with the adaptor proteins Caf4 and Mdv1, which bind directly to Fis1. Unlike Mdv1, a function for Caf4 in...

Bem3, a Cdc42 GTPase-activating protein, traffics to an intracellular compartment and recruits the secretory Rab GTPase Sec4 to endomembranes

Sequential requirements for the GTPase domain of the mitofusin Fzo1 and the ubiquitin ligase SCFMdm30 in mitochondrial outer membrane fusion

Furfural induces reactive oxygen species accumulation and cellular damage in Saccharomyces cerevisiae

Background Biofuels offer a viable alternative to petroleum-based fuel. However, current methods are not sufficient and the technology required in order to use lignocellulosic biomass as a fermentation substrate faces several challenges. One challenge is the need for a robust fermentative microorganism that can tolerate the inhibitors present during lignocellulosic fermentation...

Drosophila E-cadherin is essential for proper germ cell-soma interaction during gonad morphogenesis

Allison B. Jenkins 1 J. Michael McCaffery 0 Mark Van Doren ) 1 0 Integrated Imaging Center, Department of Biology, Mudd Hall, Johns Hopkins University , 3400 N. Charles Street, Baltimore, MD 21218

The yeast endocytic protein Epsin 2 functions in a cell-division signaling pathway

Debarati Mukherjee Brian G. Coon Daniel F. Edwards III Claudia B. Hanna Silvia A. Longhi J. Michael McCaffery Beverly Wendland Lilia A. Retegui Erfei Bi R. Claudio Aguilar

The yeast endocytic protein Epsin 2 functions in a cell-division signaling pathway

Debarati Mukherjee Brian G. Coon Daniel F. Edwards III Claudia B. Hanna Silvia A. Longhi J. Michael McCaffery Beverly Wendland Lilia A. Retegui Erfei Bi R. Claudio Aguilar - The yeast endocytic

Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant familial Parkinson's disease (PD) and also contribute to idiopathic PD. LRRK2 mutations represent the most common cause of PD with clinical and neurochemical features that are largely indistinguishable from idiopathic disease. Currently, transgenic mice expressing wild-type or disease...

Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson’s disease models

. Caldwell George W. Bell Ernest Fraenkel Antony A. Cooper Guy A. Caldwell J. Michael McCaffery Jean-Christophe Rochet Susan Lindquist () -Synuclein (-syn) is a small lipid-binding protein involved in vesicle

A role for GRIP domain proteins and/or their ligands in structure and function of the trans Golgi network

tGolgin-1 (p230, golgin-245) modulates Shiga-toxin transport to the Golgi and Golgi motility towards the microtubule-organizing centre