Search: authors:"J. A. Bouwstra"

Synthetic hydrogels as drug delivery systems

Immune Modulation by Adjuvants Combined with Diphtheria Toxoid Administered Topically in BALB/c Mice After Microneedle Array Pretreatment

PurposeIn this study, modulation of the immune response against diphtheria toxoid (DT) by various adjuvants in transcutaneous immunization (TCI) with microneedle array pretreatment was investigated.MethodsTCI was performed on BALB/c mice with or without microneedle array pretreatment using DT as a model antigen co-administrated with lipopolysaccharide (LPS), Quil A, CpG oligo...

Dissolving Microneedle Patches for Dermal Vaccination

, 2300 RA Leiden , the Netherlands 2 J. A. Bouwstra The dermal route is an attractive route for vaccine delivery due to the easy skin accessibility and a dense network of immune cells in the skin. The ... AF4 Asymmetrical flow field–flow fractionation APCs Antigen presenting cells B Brisbane J. A. Bouwstra and G. Kersten contributed equally to this work. DLS dMNs DT ELISA EV71 FDA HA HBV HIV HN HP-SEC