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24 papers found.
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Nutrition and physical activity in the prevention and treatment of sarcopenia: systematic review

Summary This systematic review summarizes the effect of combined exercise and nutrition intervention on muscle mass and muscle function. A total of 37 RCTs were identified. Results indicate that physical exercise has a positive impact on muscle mass and muscle function in subjects aged 65 years and older. However, any interactive effect of dietary supplementation appears to be ...

UK clinical guideline for the prevention and treatment of osteoporosis

Introduction In 2008, the UK National Osteoporosis Guideline Group (NOGG) produced a guideline on the prevention and treatment of osteoporosis, with an update in 2013. This paper presents a major update of the guideline, the scope of which is to review the assessment and management of osteoporosis and the prevention of fragility fractures in postmenopausal women and men age 50 ...

Efficacy of weekly teriparatide does not vary by baseline fracture probability calculated using FRAX

Summary The aim of this study was to determine the efficacy of once-weekly teriparatide as a function of baseline fracture risk. Treatment with once-weekly teriparatide was associated with a statistically significant 79 % decrease in vertebral fractures, and in the cohort as a whole, efficacy was not related to baseline fracture risk. Introduction Previous studies have suggested ...

Comparative performance of current definitions of sarcopenia against the prospective incidence of falls among community-dwelling seniors age 65 and older

Summary In this study, we compare the extent to which seven available definitions of sarcopenia and two related definitions predict the rate of falling. Our results suggest that the definitions of Baumgartner and Cruz-Jentoft best predict the rate of falls among sarcopenic versus non-sarcopenic community-dwelling seniors. Introduction The purpose of the study is to compare the ...

A comprehensive fracture prevention strategy in older adults: the European Union Geriatric Medicine Society (EUGMS) statement

Prevention of fragility fractures in older people has become a public health priority, although the most appropriate and cost-effective strategy remains unclear. In the present statement, the Interest Group on Falls and Fracture Prevention of the European Union Geriatric Medicine Society, in collaboration with the International Association of Gerontology and Geriatrics for the ...

Breaking the fragility fracture cycle

, Southampton SO16 6YD, UK 3 J. A. Kanis Centre for Metabolic Bone Diseases (WHO Collaborating Centre), University of Sheffield Medical School , Beech Hill Road, Sheffield S10 2RX, UK - Fracture begets fracture

Osteoporosis in the European Union: medical management, epidemiology and economic burden

Summary This report describes the epidemiology, burden, and treatment of osteoporosis in the 27 countries of the European Union (EU27). Introduction Osteoporosis is characterized by reduced bone mass and disruption of bone architecture, resulting in increased risk of fragility fractures which represent the main clinical consequence of the disease. Fragility fractures are associated ...

Erratum to: A meta-analysis of the effect of strontium ranelate on the risk of vertebral and non-vertebral fracture in postmenopausal osteoporosis and the interaction with FRAX®

. Kanis H. Johansson A. Oden E. V. McCloskey An error occurred in this publication due to the incorrect computation of the hazard ratio (HR) for the effects of strontium ranelate. Treatment with strontium

Osteoporosis in the European Union: a compendium of country-specific reports

J. Compston Department of Medicine, Addenbrooke's Hospital, Cambridge University , Cambridge, UK 10 J. A. Kanis WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield

SCOPE: a scorecard for osteoporosis in Europe

Summary The scorecard summarises key indicators of the burden of osteoporosis and its management in each of the member states of the European Union. The resulting scorecard elements were then assembled on a single sheet to provide a unique overview of osteoporosis in Europe. Introduction The scorecard for osteoporosis in Europe (SCOPE) is an independent project that seeks to raise ...

Erratum to: Management of osteoporosis of the oldest old

; CNRS, UMR 7211; and AP-HP, Groupe Hospitalier Pitie-Salpetriere, Department of Internal Medicine , Paris , France 12 J. A. Kanis WHO Collaborating Centre for Metabolic Bone Diseases, University of

A systematic review of hip fracture incidence and probability of fracture worldwide

Summary The country-specific risk of hip fracture and the 10-year probability of a major osteoporotic fracture were determined on a worldwide basis from a systematic review of literature. There was a greater than 10-fold variation in hip fracture risk and fracture probability between countries. Introduction The present study aimed to update the available information base available ...

Calibration of FRAX ® 3.1 to the Dutch population with data on the epidemiology of hip fractures

Summary The FRAX tool has been calibrated to the entire Dutch population, using nationwide (hip) fracture incidence rates and mortality statistics from the Netherlands. Data used for the Dutch model are described in this paper. Introduction Risk communication and decision making about whether or not to treat with anti-osteoporotic drugs with the use of T-scores are often unclear ...

Subtrochanteric fractures after long-term treatment with bisphosphonates: a European Society on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, and International Osteoporosis Foundation Working Group Report

, Italy 8 J. A. Kanis WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School , Sheffield, UK Summary This paper reviews the evidence for an associaClinical and

A reappraisal of generic bisphosphonates in osteoporosis

Summary The competitive price of generic bisphosphonates has had a marked effect on practice guidelines, but an increasing body of evidence suggests that they have more limited effectiveness than generally assumed. Introduction The purpose of this study is to review the impact of generic bisphosphonates on effectiveness in the treatment of osteoporosis. Methods This study is a ...

Assessment of health claims in the field of bone: a view of the Group for the Respect of Ethics and Excellence in Science (GREES)

Diseases, Ghent University Hospital , Ghent, Belgium 4 J. A. Kanis WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School , Sheffield, UK 5 V. Fabien-Soul Rousselot

FRAX™ and the assessment of fracture probability in men and women from the UK

Summary A fracture risk assessment tool (FRAX™) is developed based on the use of clinical risk factors with or without bone mineral density tests applied to the UK. Introduction The aim of this study was to apply an assessment tool for the prediction of fracture in men and women with the use of clinical risk factors (CRFs) for fracture with and without the use of femoral neck bone ...

European guidance for the diagnosis and management of osteoporosis in postmenopausal women

Summary Guidance is provided in a European setting on the assessment and treatment of postmenopausal women at risk of fractures due to osteoporosis. Introduction The International Osteoporosis Foundation and European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis published guidance for the diagnosis and management of osteoporosis in 2008. This ...